Results 71 to 80 of about 11,530,487 (308)

PARP inhibitors elicit distinct transcriptional programs in homologous recombination competent castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
PARP inhibitors are used to treat a small subset of prostate cancer patients. These studies reveal that PARP1 activity and expression are different between European American and African American prostate cancer tissue samples. Additionally, different PARP inhibitors cause unique and overlapping transcriptional changes, notably, p53 pathway upregulation.
Moriah L. Cunningham, Jasibel Vasquez‐Gonzalez, Samantha M. Barnada, Salome Tchotorlishvili, Latese Jones, Ryan Maguire, Genevieve Lewis, Kinza Rizwan, Jenny Deng, Salma Koachar, Drithi Patel, Hailey Shankle, Tessa Mulders, Namra Ajmal, Charalambos Solomides, Emad S. Alnemri, Teresa F. Alnemri, Ayesha A. Shafi, Leonard G. Gomella, Wm Kevin Kelly, Steven B. McMahon, Matthew J. Schiewer   +21 more
wiley   +1 more source

Urban and Transport Planning Related Exposures and Mortality: A Health Impact Assessment for Cities

Environmental Health Perspectives, 2016
Background: By 2050, nearly 70% of the global population is projected to live in urban areas. Because the environments we inhabit affect our health, urban and transport designs that promote healthy living are needed. Objective: We estimated the number of
N. Mueller, D. Rojas-Rueda, X. Basagaña, M. Cirach, T. Cole-Hunter, P. Dadvand, David Donaire-Gonzalez, M. Foraster, M. Gascon, D. Martinez, C. Tonne, M. Triguero‐Mas, Antònia Valentín, M. Nieuwenhuijsen   +13 more
semanticscholar   +1 more source

Characterizing the salivary RNA landscape to identify potential diagnostic, prognostic, and follow‐up biomarkers for breast cancer

Molecular Oncology, EarlyView.
This study explores salivary RNA for breast cancer (BC) diagnosis, prognosis, and follow‐up. High‐throughput RNA sequencing identified distinct salivary RNA signatures, including novel transcripts, that differentiate BC from healthy controls, characterize histological and molecular subtypes, and indicate lymph node involvement.
Nicholas Rajan, Irina Primac, Emre Etlioglu, Laurens Debruyne, Ann Janssen, Magy Sallam, Kevin Tabury, Roel Quintens, Wiebren Tjalma, Mohammed Abderrafi Benotmane   +9 more
wiley   +1 more source

Integrated care in Norway: State of affairs years after regulation by law

International Journal of Integrated Care, 2011
Introduction: A mandatory multidisciplinary plan for individual care, the 'Individual care Plan', was introduced by law in Norway in 2001. The regulation was established to meet the need for improved efficiency and quality of health and social services ...
Jorunn Bjerkan, Marie Richter, Anders Grimsmo, Ragnhild Hellesø, Jytte Brender   +4 more
doaj  

Using the Electronic Health Record and a School-based Education Program to Increase Asthma Management Plan Creation [PDF]

, 2020
Nicholas Antos, Santiago Encalada, Robert Rohloff, Adam Traner, Nicole Z. Fortuna, Steven P. Proper, Priya Dokken, Jessica Jansky, Ian Reineking, Brittany M. Farrell, Mark Meuer   +10 more
openalex   +1 more source

Liquid Hydroxyurea (Xromi) for Children With Sickle Cell Anemia: A New Solution Compounding Existing Problems

Pediatric Blood &Cancer, EarlyView.
Alexandra Power‐Hays, Charles T. Quinn
wiley   +1 more source

Gut microbiota diversity is prognostic in metastatic hormone receptor‐positive breast cancer patients receiving chemotherapy and immunotherapy

Molecular Oncology, EarlyView.
In this exploratory study, we investigated the relationship between the gut microbiota and outcome in patients with metastatic hormone receptor‐positive breast cancer, treated in a randomized clinical trial with chemotherapy alone or chemotherapy in combination with immune checkpoint blockade.
Andreas Ullern, Kristian Holm, Nikolai Kragøe Andresen, Andreas Hagen Røssevold, Corinna Bang, Bjørn Naume, Johannes R. Hov, Jon Amund Kyte   +7 more
wiley   +1 more source

Developing capacity in identifying cost-effective interventions to prevent and reduce obesity in China

Global Health Action
Obesity is associated with multiple noncommunicable diseases and has increased rapidly worldwide. Population obesity in China grew fourfold between 1993 and 2015, increasing most rapidly among children and adolescents.
Angela M. Jackson-Morris, Suying Chang, Christina L. Meyer, Guansheng Ma   +3 more
doaj   +1 more source

[Evaluation of health planning activities by family health teams].

Cadernos de Saúde Pública, 2012
Evaluation of health planning activities adapted to the local context is an essential part of daily work in the Family Health Strategy (FHS). This study aimed to evaluate the planning activities conducted by family health teams in Espírito Santo State ...
T. D. Sarti, C. E. Campos, E. Zandonade, Gustavo Enrico Cabral Ruschi, E. Maciel   +4 more
semanticscholar   +1 more source

Feasibility of a ctDNA multigenic panel for non‐small‐cell lung cancer early detection and disease surveillance

Molecular Oncology, EarlyView.
Plasma‐based detection of actionable mutations is a promising approach in lung cancer management. Analysis of ctDNA with a multigene NGS panel identified TP53, KRAS, and EGFR as the most frequently altered, with TP53 and KRAS in treatment‐naïve patients and TP53 and EGFR in previously treated patients.
Giovanna Maria Stanfoca Casagrande, Marcela de Oliveira Silva, Mariana Bisarro dos Reis, Rodrigo de Oliveira Cavagna, Luciane Sussuchi, Icaro Alves Pinto, Natalia Zampieri Pontes, Rodrigo Sampaio Chiarantano, Flavio Augusto Ferreira da Silva, Pedro de Marchi, Letícia Ferro Leal, Rui M. Reis   +11 more
wiley   +1 more source