Results 31 to 40 of about 673,186 (244)

Is the socioeconomic status of immigrant mothers in Brussels relevant to predict their risk of adverse pregnancy outcomes?

BMC Pregnancy and Childbirth, 2018
Background Understanding and tackling perinatal health inequities in industrialized countries requires analysing the socioeconomic determinants of adverse pregnancy outcomes among immigrant populations.
Mouctar Sow, Judith Racape, Claudia Schoenborn, Myriam De Spiegelaere   +3 more
doaj   +1 more source

Perspectives in educating molecular pathologists on liquid biopsy: Toward integrative, equitable, and decentralized precision oncology

Molecular Oncology, EarlyView.
Liquid biopsy enables minimally invasive, real‐time molecular profiling through analysis of circulating biomarkers in biological fluids. This Perspective highlights the importance of training pathologists through integrative educational programs, such as the European Masters in Molecular Pathology, to ensure effective and equitable implementation of ...
Marius Ilié, Umberto Malapelle, Catherine Alix‐Panabières, Claus Lindbjerg Andersen, Sandra Chlebowski, Vivien Lake, Caroline Lacoux, Virginie Lespinet‐Fabre, Olivier Bordone, Simon Heeke, Christophe Bontoux, Ellen Heitzer, Klaus Pantel, Paul Hofman   +13 more
wiley   +1 more source

Can health system be resilient in a Failed State? Lessons from a scoping review in Haiti

Discover Health Systems
Caribbean Small Island Developing States (SIDS) face many environmental, economic, political and social challenges. Alongside recurrent acute shocks, Haiti experiences various chronic shocks earning it the label of a ‘Failed State’.
Patricia St Louis, Alice Wautié, Samuel Lwamushi Makali, Carlene Radix, Elisabeth Paul   +4 more
doaj   +1 more source

PARP inhibition and pharmacological ascorbate demonstrate synergy in castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon, Peter T. Gallagher, Orly I. Richter, Neermala Poudel Neupane, Amy C. Mandigo, Jennifer J. McCann, Emanuela Dylgjeri, Irina Vasilevskaya, Christopher McNair, Channing J. Paller, Wm. Kevin Kelly, Karen E. Knudsen, Matthew J. Schiewer, Ayesha A. Shafi   +13 more
wiley   +1 more source

Basroparib inhibits YAP‐driven cancers by stabilizing angiomotin

Molecular Oncology, EarlyView.
Basroparib, a selective tankyrase inhibitor, suppresses Wnt signaling and attenuates YAP‐driven oncogenic programs by stabilizing angiomotin. It promotes AMOT–YAP complex formation, enforces cytoplasmic YAP sequestration, inhibits YAP/TEAD transcription, and sensitizes YAP‐active cancers, including KRAS‐mutant colorectal cancer, to MEK inhibition.
Young‐Ju Kwon, Dong Young Kim, Yuna Kim, Uk‐Il Kim, Jae‐Sung Kim   +4 more
wiley   +1 more source

A field test of empathetic refutational and motivational interviewing to address vaccine hesitancy among patients

npj Vaccines
Vaccine hesitancy is among the most concerning public health issues due to declining immunization rates worldwide. We report a mixed-methods field test of two conversational techniques that allow for an empathetic dialogue on vaccination between health ...
Angelo Fasce, Mirela Mustață, Alexandra Deliu, Dawn Holford, Linda Karlsson, Virginia Gould, Gheorghe Gindrovel Dumitra, Dana Farcasanu, Iulia Vișinescu, Pierre Verger, Stephan Lewandowsky   +10 more
doaj   +1 more source

Data and Digital Solutions to Support Surveillance Strategies in the Context of the COVID-19 Pandemic

Frontiers in Digital Health, 2021
Background: In order to prevent spread and improve control of infectious diseases, public health experts need to closely monitor human and animal populations.
Patty Kostkova, Francesc Saigí-Rubió, Francesc Saigí-Rubió, Hans Eguia, Hans Eguia, Damian Borbolla, Marieke Verschuuren, Clayton Hamilton, Natasha Azzopardi-Muscat, David Novillo-Ortiz   +9 more
doaj   +1 more source

Health Policy [PDF]

, 2023
Abstract This chapter analyses the structures, processes, and actors of health policy in Switzerland. In international comparison, Switzerland has a very well-developed health system with universal insurance coverage and high-quality care services.
Trein, Philipp, Rüefli, Christian, Vatter, Adrian   +2 more
openaire   +1 more source

Pre‐analytical optimization of cell‐free DNA and extracellular vesicle‐derived DNA for mutation detection in liquid biopsies

Molecular Oncology, EarlyView.
Pre‐analytical handling critically determines liquid biopsy performance. This study defines practical best‐practice conditions for cell‐free DNA (cfDNA) and extracellular vesicle–derived DNA (evDNA), showing how processing time, storage conditions, tube type, and plasma input volume affect DNA integrity and mutation detection.
Jonas Dohmen, Lucrezia De Santis, Bret M. Stephens, Vincent Bernard, Jörg C. Kalff, Lara Braun, Phillipp Leyendecker, Johannes Röttgen, Daniel Weissinger, Anirban Maitra, Paola A. Guerrero, Alexander Semaan   +11 more
wiley   +1 more source

The first case report of multiple thoracic vertebrae fractures caused by a low-voltage electric shock

European Journal of Medical Research, 2022
Background This paper describes a unique case—the first case of multiple fractures of the thoracic vertebrae caused by a low-voltage electric shock. Case presentation A 22-year-old male patient was diagnosed with compression fractures of Th2–Th6 caused ...
Jan Žatecký, Matúš Peteja, Wladyslaw Bartosz Gawel, Milan Lerch   +3 more
doaj   +1 more source