Results 41 to 50 of about 673,186 (244)

Digital twins to accelerate target identification and drug development for immune‐mediated disorders

FEBS Open Bio, EarlyView.
Digital twins integrate patient‐derived molecular and clinical data into personalised computational models that simulate disease mechanisms. They enable rapid identification and validation of therapeutic targets, prediction of drug responses, and prioritisation of candidate interventions.
Anna Niarakis, Philippe Moingeon
wiley   +1 more source

Population and Health Policies* [PDF]

SSRN Electronic Journal, 2009
Abstract The program evaluation literature for population and health policies is in flux, with many disciplines documenting biological and behavioral linkages from fetal development to late life mortality, chronic disease, and disability, though their implications for policy remain uncertain.
openaire   +5 more sources

Large‐scale bidirectional arrayed genetic screens identify OXR1 and EMC4 as modifiers of αSynuclein aggregation

FEBS Open Bio, EarlyView.
Activation of the mitochondrial protein OXR1 increases pSyn129 αSynuclein aggregation by lowering ATP levels and altering mitochondrial membrane potential, particularly in response to MSA‐derived fibrils. In contrast, ablation of the ER protein EMC4 enhances autophagic flux and lysosomal clearance, broadly reducing α‐synuclein aggregates.
Sandesh Neupane, Lea Nikolić, Lorenzo Maraio, Thomas Goiran, Nathan Karpilovsky, Stefano Sellitto, Vangelis Bouris, Jiang‐An Yin, Ronald Melki, Edward A Fon, Adriano Aguzzi, Elena De Cecco   +11 more
wiley   +1 more source

Can healthy ageing moderate the effects of population ageing on economic growth and health spending trends in Mongolia? A modelling study

Health Research Policy and Systems, 2022
Background  Population ageing will accelerate rapidly in Mongolia in the coming decades. We explore whether this is likely to have deleterious effects on economic growth and health spending trends and whether any adverse consequences might be moderated ...
Gemma A. Williams, Jonathan Cylus, Lynn Al Tayara, Tomáš Roubal, Tsolmongerel Tsilaajav, Sarah L. Barber   +5 more
doaj   +1 more source

[Men's health policy].

Revista de saude publica, 2012
The paper discusses the articulation among epidemiological information systems, scientific production and men's health policies. Three secondary sources were used: data from the Ministry of Health (Mortality and Hospital Information Systems, Surveillance of Protection and Risk Factors for Chronic Diseases through Telephone Survey), papers published in ...
Schwarz, Eduardo, Gomes, Romeu, Couto, Márcia Thereza, Moura, Erly Catarina de, Carvalho, Sarah de Araújo, Silva, Simione Fátima Cesar da   +5 more
openaire   +2 more sources

Re‐Awakening Public Attention to the Silent Pandemic of Cancer Among Older Adults in Low‐ and Middle‐Income Countries

Aging and Cancer, EarlyView.
ABSTRACT As global populations age, cancer is increasingly becoming a leading cause of morbidity and mortality among older adults, particularly in low‐ and middle‐income countries (LMICs). Despite accounting for the majority of new cancer cases and deaths, older individuals remain underrepresented in cancer research, clinical guidelines, and health ...
Ibrahim Bidemi Abdullateef, Sunkanmi Folorunsho, Abdulazeez Opeyemi Abdulganiyu   +2 more
wiley   +1 more source

Tracking Motor Progression and Device‐Aided Therapy Eligibility in Parkinson's Disease

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective To characterise the progression of motor symptoms and identify eligibility for device‐aided therapies in Parkinson's disease, using both the 5‐2‐1 criteria and a refined clinical definition, while examining differences across genetic subgroups.
David Ledingham, Sahana Sathyanarayana, Charlotte B. Stewart, Robyn Iredale, Victoria Foster, Debra Galley, Mark Baker, Nicola Pavese   +7 more
wiley   +1 more source

Frailty Exacerbates Disability in Progressive Multiple Sclerosis

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background To evaluate frailty in severe progressive multiple sclerosis (PMS) and to investigate the underlying mechanisms. Methods This prospective, cross‐sectional, multicenter study enrolled a late severe PMS group requiring skilled nursing (n = 53) and an age, sex, and disease duration‐matched control PMS group (n = 53).
Taylor R. Wicks, Anna Wolska, Diala Ghazal, Dejan Jakimovski, Bianca Weinstock‐Guttman, Alexander Burnham, Niels Bergsland, Michael G. Dwyer, Alan T. Remaley, Robert Zivadinov, Murali Ramanathan   +10 more
wiley   +1 more source

Leishmaniasis in Greece: Prospects of transitioning to a One Health surveillance system

One Health
Leishmaniasis is a high burden neglected disease in the Mediterranean ecoregion, lacking surveillance attention. We aimed to provide an overview of the state of leishmaniasis surveillance in Greece, investigating the prospect of transitioning to a One ...
Emmanouil Alexandros Fotakis, Dimitris Papamichail, Sofia Boutsini, Eleni Patsoula, Takis Panagiotopoulos   +4 more
doaj   +1 more source

Analysing public sector institutional capacity for health workforce governance in the South-East Asia region of WHO

Human Resources for Health, 2019
Background In order to analyse the institutional capacity for health workforce policy development and implementation in countries in the South-East Asia region, the WHO facilitated a cross-sectional analysis of functions performed, structure, personnel ...
Giorgio Cometto, Esther Nartey, Tomas Zapata, Mikiko Kanda, Yunus Md, Kavita Narayan, Kirana Pritasari, Aishath Irufa, Ramkrishna Lamichhane, Dileep De Silva, Thinakorn Noree   +10 more
doaj   +1 more source