Results 91 to 100 of about 1,032,633 (361)
Aβ42 promotes the aggregation of α‐synuclein splice isoforms via heterogeneous nucleation
FEBS Letters, EarlyView.The aggregation of amyloid‐β (Aβ) and α‐synuclein (αSyn) is associated with Alzheimer's and Parkinson's diseases. This study reveals that Aβ aggregates serve as potent nucleation sites for the aggregation of αSyn and its splice isoforms, shedding light on the intricate interplay between these two pathogenic proteins.
Alexander Röntgen +2 more
wiley +1 more source
METHOD OF BUILDING AN INFORMATION SYSTEM FOR HEALTHCARE DISTRICT DIVISION [PDF]
, 2017 Information resources are an essential foundation for the development of a scientific approach in decision-making. The scientific approach to the development of health policy allows to conduct reliable international comparisons, determine ...
Shevtsova, O +2 more
core +3 more sources
FEBS Letters, EarlyView.This work presents the characterization of MvoDUF2193, a Methanococcus voltae (Mvo) protein from the domain of unknown function (DUF) 2193 family. We demonstrate that MvoDUF2193 binds a single [4Fe–4S] cluster per subunit and that cluster occupancy regulates the transition from an apo tetramer to a [4Fe–4S] monomeric form. This structural transition is
Emily M. Dieter +8 more
wiley +1 more source
Salud Pública de México, 2007 La definición explícita de prioridades en intervenciones de salud representa una oportunidad para México de equilibrar la presión y la complejidad de una transición epidemiológica avanzada, con políticas basadas en evidencias generadas por la inquietud ...
Eduardo González-Pier +12 more
doaj
Evaluating community deliberations about health research priorities
Health Expectations, 2019 Context Engaging underrepresented communities in health research priority setting could make the scientific agenda more equitable and more responsive to their needs.
Susan Dorr Goold +8 more
doaj +1 more source
FEBS Letters, EarlyView.In this work, we reveal how different enzyme binding configurations influence the fluorescence decay of NAD(P)H in live cells using time‐resolved anisotropy imaging and fluorescence lifetime imaging microscopy (FLIM). Mathematical modelling shows that the redox states of the NAD and NADP pools govern these configurations, shaping their fluorescence ...
Thomas S. Blacker +8 more
wiley +1 more source
National cancer programme work plan 2014/15 [PDF]
The National Cancer Programme Work Plan 2014/15 covers national, regional and local priority activities for cancer. Overview The National Cancer Programme: brings together the work of district health boards, regional cancer networks and the Ministry
core
Health Care Opinion Leaders' Views on Priorities for the Obama Administration [PDF]
, 2009 Presents results of a survey of experts on priorities in healthcare reform and related economic stimulus for the Barack Obama administration, including new regulations, employer financing of coverage, and an insurance exchange with a public ...
Karen Davis +3 more
core
Neutrophil deficiency increases T cell numbers at the site of tissue injury in mice
FEBS Letters, EarlyView.In wild‐type mice, injury or acute inflammation induces neutrophil influx followed by macrophage accumulation. Mcl1ΔMyelo (neutrophil‐deficient) mice lack neutrophils, and in response to muscle injury show fewer macrophages and exhibit strikingly elevated T‐cell numbers, primarily non‐conventional “double‐negative” (DN) αβ and γδ T cells.
Hajnalka Halász +6 more
wiley +1 more source
Health and the Economy : a statement of concern [PDF]
, 2004 The relationship between health and the economy is an intimate and complex one. The economy of health and the apportioning of funds to different medical services and health care programs are issues that depend on the health profile of a given community ...
Attard Montalto, Simon +5 more
core