Results 121 to 130 of about 1,128,390 (308)

The moral relevance of personal characteristics in setting health care priorities [PDF]

open access: yes
This paper discusses the moral relevance of accounting for various personal characteristics when prioritising between groups of patients. After a review of the results from empirical studies, we discuss the ethical reasons which might explain – and ...
Dolan, Paul   +3 more
core  

Cell wall target fragment discovery using a low‐cost, minimal fragment library

open access: yesFEBS Letters, EarlyView.
LoCoFrag100 is a fragment library made up of 100 different compounds. Similarity between the fragments is minimized and 10 different fragments are mixed into a single cocktail, which is soaked to protein crystals. These crystals are analysed by X‐ray crystallography, revealing the binding modes of the bound fragment ligands.
Kaizhou Yan   +5 more
wiley   +1 more source

Research priorities of women at risk for preterm birth: findings and a call to action. [PDF]

open access: yes, 2020
BACKGROUND:Traditional hierarchical approaches to research give privilege to small groups with decision-making power, without direct input from those with lived experience of illness who bear the burden of disease. A Research Justice framework values the
Edwards, Lisa   +11 more
core  

The (Glg)ABCs of cyanobacteria: modelling of glycogen synthesis and functional divergence of glycogen synthases in Synechocystis sp. PCC 6803

open access: yesFEBS Letters, EarlyView.
We reconstituted Synechocystis glycogen synthesis in vitro from purified enzymes and showed that two GlgA isoenzymes produce glycogen with different architectures: GlgA1 yields denser, highly branched glycogen, whereas GlgA2 synthesizes longer, less‐branched chains.
Kenric Lee   +3 more
wiley   +1 more source

The legal path for priority setting in Chile: a critical analysis to improve health planning and stewardship

open access: yesFrontiers in Public Health
Health systems have committed their path to universal health coverage using health planning to accomplish their goals of efficiency, equity and sustainability.
Manuel Antonio Espinoza   +5 more
doaj   +1 more source

Health and nutrition: emerging and reemerging issues in developing countries [PDF]

open access: yes
CONTENTS: Brief 1. Overview / Rafael Flores Brief 2. The Global Burden of Disease / Alan D. Lopez Brief 3. HIV/AIDS / Anthony Barnett and Gabriel Rugalema Brief 4. Malaria / Andrea Egan Brief 5. Tuberculosis / Ariel Pablos-Mendez Brief 6.
Flores, Rafael, ed.   +1 more
core  

The Governors Speak 2007: A Report on the State-of-the-State Addresses of the Nation's and U.S. Territories' Governors [PDF]

open access: yes, 2007
As improved economic conditions and higher state revenues offer governors an opportunity to invest in long-term priorities, most are focusing action on strengthening their state's prospects for long-term economic growth, according to the 2007 state-of ...
Thad R. Nodine
core  

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

open access: yesFEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

Devolved governance systems [PDF]

open access: yes, 2008
This article assesses the extent, nature and outcomes of the recently devolved health service governance in the four countries which comprise the United Kingdom.
Storey, John, Winchester, Nik
core  

Transferrin receptor 1‐mediated iron uptake supports thermogenic activation in human cervical‐derived adipocytes

open access: yesFEBS Letters, EarlyView.
In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai   +9 more
wiley   +1 more source

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