Results 191 to 200 of about 1,128,390 (308)

Balancing public health priorities and inclusivity in medical education: a clarification on curriculum revisions. [PDF]

Lancet Reg Health Southeast Asia
Beg MJ, Chaitanya Reddy BS, Singh Sethi MI.   +2 more
europepmc   +1 more source

Colorectal cancer‐derived FGF19 is a metabolically active serum biomarker that exerts enteroendocrine effects on mouse liver

Molecular Oncology, EarlyView.
Meta‐transcriptome analysis identified FGF19 as a peptide enteroendocrine hormone associated with colorectal cancer prognosis. In vivo xenograft models showed release of FGF19 into the blood at levels that correlated with tumor volumes. Tumoral‐FGF19 altered murine liver metabolism through FGFR4, thereby reducing bile acid synthesis and increasing ...
Jordan M. Beardsley, Michael W. Rohr, Joseph A. Goode, Sai Preethi Nakkina, Jignesh G. Parikh, Deborah A. Altomare   +5 more
wiley   +1 more source

Global kidney health priorities-perspectives from the ISN-GKHA. [PDF]

Nephrol Dial Transplant
Okpechi IG, Luyckx VA, Tungsanga S, Ghimire A, Jha V, Johnson DW, Bello AK.   +6 more
europepmc   +1 more source

Identification of serum protein biomarkers for pre‐cancerous lesions associated with pancreatic ductal adenocarcinoma

Molecular Oncology, EarlyView.
This work identified serum proteins associated with pancreatic epithelial neoplasms (PanINs) and early‐stage PDAC. Proteomics screens assessed genetically engineered mice with abundant PanINs, KPC mice (Lox‐STOP‐Lox‐KrasG12D/+ Lox‐STOP‐Lox‐Trp53R172H/+ Pdx1‐Cre) before PDAC development and also early‐stage PDAC patients (n = 31), compared to benign ...
Hannah Mearns, Jaclyn S. Long, Sergio Lilla, Kelly Hodge, Marcus J. G. W. Ladds, Colin Nixon, Paula Fernández‐Palanca, Sara Zanivan, Pilar Acedo, Stephen P. Pereira, Kevin M. Ryan   +10 more
wiley   +1 more source

Redefining health priorities: Sub-Saharan Africa's new frontier in disease burden. [PDF]

J Glob Health
Zerfu TA, Tareke AA, Biadgilign S.
europepmc   +1 more source

Subtype‐specific enhancer RNAs define transcriptional regulators and prognosis in breast cancers

Molecular Oncology, EarlyView.
This study employed machine learning methodologies to perform the subtype‐specific classification of RNA‐seq data sets, which are mapped on enhancers from TCGA‐derived breast cancer patients. Their integration with gene expression (referred to as ProxCReAM eRNAs) and chromatin accessibility profiles has the potential to identify lineage‐specific and ...
Aamena Y. Patel, Peyman Zarrineh, Nathnael T. Tuffa, Jigar H. Sheth, Sumitra Mohan, Mudassar Iqbal, Sankari Nagarajan   +6 more
wiley   +1 more source

The Need for a Travel Medicine Diploma in Saudi Arabia: Addressing National and Global Health Priorities. [PDF]

J Epidemiol Glob Health
Sheerah HA, Brazanji NA, Al-Zahrani FA, Muammar NB, AlBassam AM, Alfaya MA, Aldosaimani A, Alshahrani NZ, Alosaimi M, Almaziad S, AlZunitan MA, Farahat FM, Alshamrani MM.   +12 more
europepmc   +1 more source

Genetic attenuation of ALDH1A1 increases metastatic potential and aggressiveness in colorectal cancer

Molecular Oncology, EarlyView.
Aldehyde dehydrogenase 1A1 (ALDH1A1) is a cancer stem cell marker in several malignancies. We established a novel epithelial cell line from rectal adenocarcinoma with unique overexpression of this enzyme. Genetic attenuation of ALDH1A1 led to increased invasive capacity and metastatic potential, the inhibition of proliferation activity, and ultimately ...
Martina Poturnajova, Zuzana Kozovska, Ondrej Pos, Kristina Pavlov, Sachin Gulati, Peter Makovicky, Kristina Jakic, Monika Burikova, Eva Sedlackova, Barbora Svitkova, Silvia Tyciakova, Vojtech Bystry, Nicolas Blavet, Boris Tichy, Matej Hrnciar, Jaroslav Budis, Miroslav Tomas, Peter Dubovan, Georgina Kolnikova, Veronika Repaska, Nikoleta Mojzesova, Eva Zomborska, Daniel Pindak, Michal Mego, Tomas Szemes, Miroslava Matuskova   +25 more
wiley   +1 more source

Regional health priorities for dementia: a roadmap for the Western Pacific. [PDF]

Lancet Reg Health West Pac
Timmins HC, Mok VCT, Kim SH, Shahrizaila N, Sung JY, Sobue G, Agustini S, Ward S, Anstey KJ, Talbot DL, Mazumder S, Tu S, Tan RH, Shin-Yi Lin C, O'Callaghan C, Michaelian JC, Jeon YH, Foxe D, Naismith SL, Piguet O, Ahmed R, Devenney E, Park SB, Kiernan MC.   +23 more
europepmc   +1 more source

Cardiovascular Health—A Workplace Priority [PDF]

AAOHN Journal, 2002
openaire   +2 more sources