Disruption of SETD3‐mediated histidine‐73 methylation by the BWCFF‐associated β‐actin G74S mutation
FEBS Letters, EarlyView.The β‐actin G74S mutation causes altered interaction of actin with SETD3, reducing histidine‐73 methylation efficiency and forming two distinct actin variants. The variable ratio of these variants across cell types and developmental stages contributes to tissue‐specific phenotypical changes. This imbalance may impair actin dynamics and mechanosensitive
Anja Marquardt +8 more
wiley +1 more source
Prevalence of dementia in Colombian populations
Dementia & NeuropsychologiaWith the gradual increase in the life expectancy of the population due to scientific progress and public health at the service of society, the prevalence of dementia has been increasing at different rates worldwide.
Efraín Amaya Vargas +5 more
doaj +1 more source
Multi-level manifestations of sexual stigma among men with same-gender sexual experience in Ghana
BMC Public Health, 2023 Sexual stigma and discrimination toward men who have same-gender sexual experiences are present across the globe. In Ghana, same-gender sexual desires and relationships are stigmatized, and the stigma is sanctioned through both social and legal processes.
Khalida Saalim +9 more
doaj +1 more source
Bridging the gap between methods research and the needs of policy makers: A review of the research priorities of the National Institute for Health and Clinical Excellence [PDF]
, 2011 Objectives: The aim of this study was to establish a list of priority topics for methods research to support decision making at the National Institute for Health and Clinical Excellence (NICE).
Cooksey +4 more
core +1 more source
Circulating histones as clinical biomarkers in critically ill conditions
FEBS Letters, EarlyView.Circulating histones are emerging as promising biomarkers in critical illness due to their diagnostic, prognostic, and therapeutic potential. Detection methods such as ELISA and mass spectrometry provide reliable approaches for quantifying histone levels in plasma samples.
José Luis García‐Gimenez +17 more
wiley +1 more source
Priorities and priority-setting in health care in the Netherlands.
Croatian medical journal, 1998 Since 1990, the priority-setting has become one of the key issues in making choices in health care. In 1991, the now famous Dunning Report was presented to the Dutch Cabinet. One of its main conclusions was that health services should satisfy four criteria: necessary care, effectiveness, efficiency, and individual responsibility.
Hermans, HEGM (Herbert), Exter, Andre
openaire +3 more sources
Bermuda Civil Society Project: Analysis of Social Service Agencies [PDF]
, 2010 Offers a research synthesis on Bermuda's nonprofit sector, including trends and challenges, landscape, and snapshots of the health, education, workforce, and youth violence issue areas; an analysis of agency priorities and data; and ...
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Improving animal health on organic dairy farms: stakeholder views on policy options [PDF]
, 2020 Although ensuring good animal health is a stated aim of organic livestock farming and an important reason why consumers purchase organic products, the health states actually achieved are comparable to those in conventional farming.
Blanco-Penedo, Isabel +7 more
core +4 more sources
FEBS Letters, EarlyView.This study reveals how prime editing guide RNA (pegRNA) secondary structure and reverse transcriptase template length affect prime editing efficiency in correcting the phospholamban R14del cardiomyopathy‐associated mutation. Insights support the design of structurally optimized enhanced pegRNAs for precise gene therapy.
Bing Yao +7 more
wiley +1 more source
Gap Analysis of Environmental Health Research in Malawi : Report to the National Commission of Science and Technology [PDF]
, 2010 The aim of this consultancy was to assess the current gaps in research for the environmental health sector in Malawi, and to recommend research priorities and an effective action plan to address these ...
Lungu, Kingsley +2 more
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