Results 71 to 80 of about 220,169 (313)

Peptide‐based ligand antagonists block a Vibrio cholerae adhesin

FEBS Letters, EarlyView.
The structure of a peptide‐binding domain of the Vibrio cholerae adhesin FrhA was solved by X‐ray crystallography, revealing how the inhibitory peptide AGYTD binds tightly at its Ca2+‐coordinated pocket. Structure‐guided design incorporating D‐amino acids enhanced binding affinity, providing a foundation for developing anti‐adhesion therapeutics ...
Mingyu Wang, Grace Du, Charity Yongo‐Luwawa, Angelina Lu, Brett Kinrade, Kim Munro, Karl E. Klose, William D. Lubell, Peter Davies, Shuaiqi Guo   +9 more
wiley   +1 more source

Cost Considerations in Healthcare: Review Analysis of Break-even Point of Spirometry [PDF]

Journal of Clinical and Diagnostic Research
For financial sustainability and service-based efficiency in healthcare services, there is a need for better understanding and application of cost analysis, Break-even Point (BEP) analysis, and Cost-benefit Analysis (CBA).
Ankanahalli Ramu Somashekhar, V Nancy Jeniffer, K Sindhu, Da Chirag, Smitha R Chandra   +4 more
doaj   +1 more source

Real‐time assay of ribonucleotide reductase activity with a fluorescent RNA aptamer

FEBS Letters, EarlyView.
Ribonucleotide reductases (RNR) synthesize DNA building blocks de novo, making them crucial in DNA replication and drug targeting. FLARE introduces the first single‐tube real‐time coupled RNR assay, which enables isothermal tracking of RNR activity at nanomolar enzyme levels and allows the reconstruction of allosteric regulatory patterns and rapid ...
Jacopo De Capitani, Noemi E. Nwosu, Viktoria Gocke, Müge Kasanmascheff, Hannes Mutschler   +4 more
wiley   +1 more source

A 10-Step Method for Fair Priority-Setting Processes: A Qualitative Case Study from Zanzibar

Health Systems & Reform
Health systems worldwide face challenges in managing resource scarcity, necessitating systematic and fair approaches to prioritize essential health services.
Omar Mwalim, Sanaa Said, Subira Suleiman, Fatma Bakar, Haji Khamis, Dhameera Mohammed, Zuhura Amour, Omar Mussa, Abdulmajid Jecha, Abdul-Latif Haji, Ole F. Norheim, Ingrid Miljeteig, Austen Davis, Peter Hangoma, Kjell Arne Johansson   +14 more
doaj   +1 more source

Setting global health research priorities

BMJ, 2003
When the G8 countries met in Canada in 2002 the topics of security, health, and Africa figured prominently. The three issues are related. Africa's human health is reeling from HIV/AIDS and other infectious diseases, posing national and regional security risks.
Ronald, Labonte, Jerry, Spiegel
openaire   +3 more sources

Stakeholders’ participation in planning and priority setting in the context of a decentralised health care system: the case of prevention of mother to child transmission of HIV programme in Tanzania [PDF]

, 2013
Elizabeth H. Shayo, Leonard E. G. Mboera, Astrid Blystad   +2 more
openalex   +1 more source

Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation

FEBS Letters, EarlyView.
Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe, Tanmay Kumar Mohanty, Rashna Bhandari, Dorothea Fiedler   +3 more
wiley   +1 more source

Systematic review for the development of a pharmaceutical and medical products prioritization framework

Journal of Pharmaceutical Policy and Practice, 2019
Objective To identify and analyze the criteria, approaches, and conceptual frameworks, used for national/international priority setting. Data sources We performed a search of the main biomedical databases (Medline/PubMed, Embase, Centre for Reviews and ...
Alberto Frutos Pérez-Surio, Mercedes Gimeno-Gracia, Ma. Aránzazu Alcácera López, Ma. Asunción Sagredo Samanes, Ma. del Puerto Pardo Jario, Ma. del Tránsito Salvador Gómez   +5 more
doaj   +1 more source

Function‐driven design of a surrogate interleukin‐2 receptor ligand

FEBS Letters, EarlyView.
Interleukin (IL)‐2 signaling can be achieved and precisely fine‐tuned through the affinity, distance, and orientation of the heterodimeric receptors with their ligands. We designed a biased IL‐2 surrogate ligand that selectively promotes effector T and natural killer cell activation and differentiation. Interleukin (IL) receptors play a pivotal role in
Ziwei Tang, Zelin Cheng, Teng Li, Fulian Wang, Liangminghui Zhang, Xiuxiu He, Lili Liu, Wei Wang, Aibin Liang, Guang Yang   +9 more
wiley   +1 more source

Mechanisms of parasite‐mediated disruption of brain vessels

FEBS Letters, EarlyView.
Parasites can affect the blood vessels of the brain, often causing serious neurological problems. This review explains how different parasites interact with and disrupt these vessels, what this means for brain health, and why these processes matter. Understanding these mechanisms may help us develop better ways to prevent or treat brain infections in ...
Leonor Loira, Sílvia Arroz‐Madeira, Cláudio A. Franco, Sara Silva Pereira   +3 more
wiley   +1 more source