Results 81 to 90 of about 220,169 (313)
OP105 Gaps, Challenges And Priorities For Neurodegenerative Disease Research And Health Technology Assessment [PDF]
, 2022 Fatima Salih +7 more
openalex +1 more source
Multiple ETS family transcription factors bind mutant p53 via distinct interaction regions
FEBS Letters, EarlyView.Mutant p53 gain‐of‐function is thought to be mediated by interaction with other transcription factors. We identify multiple ETS transcription factors that can bind mutant p53 and found that this interaction can be promoted by a PXXPP motif. ETS proteins that strongly bound mutant p53 were upregulated in ovarian cancer compared to ETS proteins that ...
Stephanie A. Metcalf +6 more
wiley +1 more source
Research priorities in environmental health
BMJ, 1999 Education and debate pp 1678-93 Environmental issues are often high up on the political agenda. However, environmental health aspects tend to receive a lower priority. When conflicts of interest occur with other environmentalconcerns this may result in negative consequences for public health.
openaire +3 more sources
Migration and health: a global public health research priority [PDF]
, 2018 Kolitha Wickramage +4 more
openalex +1 more source
With much of England’s NHS under severe pressure, should health inequalities be a priority? [PDF]
, 2023 Richard M. Wood
openalex +1 more source
The newfound relationship between extrachromosomal DNAs and excised signal circles
FEBS Letters, EarlyView.Extrachromosomal DNAs (ecDNAs) contribute to the progression of many human cancers. In addition, circular DNA by‐products of V(D)J recombination, excised signal circles (ESCs), have roles in cancer progression but have largely been overlooked. In this Review, we explore the roles of ecDNAs and ESCs in cancer development, and highlight why these ...
Dylan Casey, Zeqian Gao, Joan Boyes
wiley +1 more source
Setting research priorities across science, technology, and health sectors: the Tanzania experience [PDF]
, 2015 Sylvia de Haan +7 more
openalex +1 more source
In situ molecular organization and heterogeneity of the Legionella Dot/Icm T4SS
FEBS Letters, EarlyView.We present a nearly complete in situ model of the Legionella Dot/Icm type IV secretion system, revealing its central secretion channel and identifying new components. Using cryo‐electron tomography with AI‐based modeling, our work highlights the structure, variability, and mechanism of this complex nanomachine, advancing understanding of bacterial ...
Przemysław Dutka +11 more
wiley +1 more source