Results 121 to 130 of about 2,136,146 (305)

Tau acetylation at K331 has limited impact on tau pathology in vivo

FEBS Letters, EarlyView.
We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto, Yukio Matsuba, Mika Takahashi, Takaomi C. Saido   +3 more
wiley   +1 more source

Effectiveness of Online Traditional Exercise Program on the Stress Level of Elderly

Journal of Aging Research
Conclusion: Effectiveness of online traditional dance exercise program on the stress level of the elderly. It can reduce stress levels in the elderly. It could be applied with elderly in the community healthcare setting.
Suwat Jitdamrong, Kunlasatree Jumpathong, Choladda Nanglad, Yadaporn Ketkaeo, Dolrada Malicum, Ormjai Taejarernwiriyakul   +5 more
doaj   +1 more source

Calpain small subunit homodimerization is robust and calcium‐independent

FEBS Letters, EarlyView.
Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy, Trina Dykstra‐MacPherson, Mathias A. Bell, Peter L. Davies, Ruby May A. Sullan   +4 more
wiley   +1 more source

Health promotion research: dilemmas and challenges [PDF]

, 2001
Koelen, M.A., Vaandrager, L., Colomér, C.   +2 more
core   +2 more sources

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

A methionine‐lined active site governs carbocation stabilization and product specificity in a bacterial terpene synthase

FEBS Letters, EarlyView.
This study reveals a unique active site enriched in methionine residues and demonstrates that these residues play a critical role by stabilizing carbocation intermediates through novel sulfur–cation interactions. Structure‐guided mutagenesis further revealed variants with significantly altered product profiles, enhancing pseudopterosin formation. These
Marion Ringel, Carl P. O. Helmer, Shani Zev, Ronja Driller, Emily Buhr, Markus Reinbold, Renana Schwartz, Gabriel Foley, Mikael Boden, Daniel Garbe, Gerhard Schenk, Dan Thomas Major, Bernhard Loll, Thomas Brück   +13 more
wiley   +1 more source

CHALLENGES IN COMMUNITY PROMOTION HEALTH :INTERGENERATIONAL INSTANT NOODLE EATING HABIT [PDF]

, 2009
Living in a hurry time, nowadays became a life style. In eating, people turn to instant food as a practice choice in preparing meals. In Indonesia, instant noodle is the most popular item in instant food On the other side, eating too much instant food is
Rahaju, Soerjantini, Wahjuningsih, Sri
core  

Valosin‐containing protein counteracts ATP‐driven dissolution of FUS condensates through its ATPase activity in vitro

FEBS Letters, EarlyView.
Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura, Shin‐ichi Tate, Kyota Yasuda   +2 more
wiley   +1 more source

Diversity and complexity in neural organoids

FEBS Letters, EarlyView.
Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley   +1 more source

THE ASSOCIATION BETWEEN SCREEN TIME AND PSYCHOLOGICAL DISTRESS AMONG INDONESIAN FEMALE ADOLESCENTS: A CROSS-SECTIONAL STUDY

Journal of Community Mental Health and Public Policy
Background: Excessive smartphone use has a negative impact on health, especially in the adolescent age group. Adolescent females who screen time for two hours or more a day after school have the potential to experience psychological distress. Purpose: To
Alma Feriyanti, Rina Tri Agustini, Lies Permana, Nur Rohmah, Annisa Nurrachmawati, Agustin Putri Rahayu, Mohammad Fikri   +6 more
doaj   +1 more source