Results 91 to 100 of about 7,839,076 (336)

Ion channel function of polycystin‐2/polycystin‐1 heteromer revealed by structure‐guided mutagenesis

FEBS Letters, EarlyView.
Mutations in polycystin‐1 (PC1) or polycystin‐2 (PC2) cause autosomal‐dominant polycystic kidney disease (ADPKD). We generated a novel gain‐of‐function PC2/PC1 heteromeric ion channel by mutating pore‐blocking residues. Moreover, we demonstrated that PC2 will preferentially assemble with PC1 to form heteromeric complexes when PC1 is co‐expressed ...
Tobias Staudner, Juthamas Khamseekaew, M. Gregor Madej, Linda Geiges, Bardha Azemi, Christine Ziegler, Christoph Korbmacher, Alexandr V. Ilyaskin   +7 more
wiley   +1 more source

Effectiveness of Online Traditional Exercise Program on the Stress Level of Elderly

Journal of Aging Research
Conclusion: Effectiveness of online traditional dance exercise program on the stress level of the elderly. It can reduce stress levels in the elderly. It could be applied with elderly in the community healthcare setting.
Suwat Jitdamrong, Kunlasatree Jumpathong, Choladda Nanglad, Yadaporn Ketkaeo, Dolrada Malicum, Ormjai Taejarernwiriyakul   +5 more
doaj   +1 more source

Assessment of 2016 Taiwan tobacco control performance based on WHO MPOWER guidelines

Tobacco Induced Diseases, 2018
Background Smoking kills more than 27,000 people each year in Taiwan. This study aims to demonstrate the significant progress with Taiwan MPOWER performances and compare achievements with OECD and other Asian countries.
Ho-Yi Chung, Shu-Ying Lo, Yu-Juan Liu, Mei-Chu Lin, Li-Hui Yu, Ying-Wei Wang, Yi-Ren Wang   +6 more
doaj   +1 more source

Decoding the dual role of autophagy in cancer through transcriptional and epigenetic regulation

FEBS Letters, EarlyView.
Transcriptional and epigenetic regulation controls autophagy, which exerts context‐dependent effects on cancer: Autophagy suppresses tumorigenesis by maintaining cellular homeostasis or promotes tumor progression by supporting survival under stress. In this “In a Nutshell” article, we explore the intricate mechanisms of the dual function of autophagy ...
Young Suk Yu, Ik Soo Kim, Sung Hee Baek
wiley   +1 more source

THE ASSOCIATION BETWEEN SCREEN TIME AND PSYCHOLOGICAL DISTRESS AMONG INDONESIAN FEMALE ADOLESCENTS: A CROSS-SECTIONAL STUDY

Journal of Community Mental Health and Public Policy
Background: Excessive smartphone use has a negative impact on health, especially in the adolescent age group. Adolescent females who screen time for two hours or more a day after school have the potential to experience psychological distress. Purpose: To
Alma Feriyanti, Rina Tri Agustini, Lies Permana, Nur Rohmah, Annisa Nurrachmawati, Agustin Putri Rahayu, Mohammad Fikri   +6 more
doaj   +1 more source

Autophagy in cancer and protein conformational disorders

FEBS Letters, EarlyView.
Autophagy plays a crucial role in numerous biological processes, including protein and organelle quality control, development, immunity, and metabolism. Hence, dysregulation or mutations in autophagy‐related genes have been implicated in a wide range of human diseases.
Sergio Attanasio
wiley   +1 more source

The use of e-health and m-health tools in health promotion and primary prevention among older adults: a systematic literature review

BMC Health Services Research, 2016
BackgroundThe use of e-health and m-health technologies in health promotion and primary prevention among older people is largely unexplored. This study provides a systematic review of the evidence on the scope of the use of e-health and m-health tools in
R. Kampmeijer, M. Pavlova, M. Tambor, S. Golinowska, W. Groot   +4 more
semanticscholar   +1 more source

Protonophore activity of short‐chain fatty acids induces their intracellular accumulation and acidification

FEBS Letters, EarlyView.
The protonated form of butyrate, as well as other short‐chain fatty acids (SCFAs), is membrane permeable. In acidic extracellular environments, this can lead to intracellular accumulation of SCFAs and cytosolic acidification. This phenomenon will be particularly relevant in acidic environments such as the large intestine or tumor microenvironments ...
Muwei Jiang, Frans Bianchi, Geert van den Bogaart   +2 more
wiley   +1 more source

Modifications in FLAP's second cytosolic loop influence 5‐LOX interaction, inhibitor binding, and leukotriene formation

FEBS Letters, EarlyView.
The enzyme 5‐lipoxygenase (5‐LOX) catalyzes the first step in the biosynthesis of leukotrienes (LTs) involved in inflammatory pathophysiology. After cellular stimulation, 5‐LOX translocates to the nucleus, interacting with the 5‐LOX‐activating protein (FLAP) to form LTA4 from arachidonic acid (AA).
Erik Romp, Katharina Rataj, Stefanie König, Marcia E. Newcomer, Oliver Werz, Ulrike Garscha   +5 more
wiley   +1 more source

Social Promoter Score (SPS) and Review Network: A Method and a Tool for Predicting Financial Health of an Online Shopping Brand [PDF]

arXiv, 2018
The conventional way of summarizing ratings or sentiment of reviews of customers on products of an online shopping brand are not sufficient to evaluate the financial health of that brand. It overlooks the social standing and influence of individual customers.
arxiv