Results 91 to 100 of about 11,060,200 (359)

Microbial exopolysaccharide production by polyextremophiles in the adaptation to multiple extremes

FEBS Letters, EarlyView.
Polyextremophiles are microorganisms that endure multiple extreme conditions by various adaptation strategies that also include the production of exopolysaccharides (EPSs). This review provides an integrated perspective on EPS biosynthesis, function, and regulation in these organisms, emphasizing their critical role in survival and highlighting their ...
Tracey M Gloster, Ebru Toksoy Öner
wiley   +1 more source

Development of a minimum data set for a blockchain-based personal health records (PHRs), for patient/physician interaction in family medicine

Journal of Education and Health Promotion
BACKGROUND: The primary requirement for a capable patient health record (PHR) that can interact appropriately with the family medicine system and collect and share qualified data is a minimum data set (MDS) aligned with family medicine’s functions and ...
Mehdi Hajebrahimi, Mostafa Langarizadeh, Alireza Nikseresht   +2 more
doaj   +1 more source

Recent adverse mortality trends in Scotland: comparison with other high-income countries

BMJ Open, 2019
Objective Gains in life expectancy have faltered in several high-income countries in recent years. Scotland has consistently had a lower life expectancy than many other high-income countries over the past 70 years.
Colin Fischbacher, Gerry McCartney, Jon Minton, Julie Ramsay, Maria Kaye-Bardgett, Grant M A Wyper   +5 more
doaj   +1 more source

A large‐scale retrospective study in metastatic breast cancer patients using circulating tumour DNA and machine learning to predict treatment outcome and progression‐free survival

Molecular Oncology, EarlyView.
There is an unmet need in metastatic breast cancer patients to monitor therapy response in real time. In this study, we show how a noninvasive and affordable strategy based on sequencing of plasma samples with longitudinal tracking of tumour fraction paired with a statistical model provides valuable information on treatment response in advance of the ...
Emma J. Beddowes, Mario Ortega Duran, Solon Karapanagiotis, Alistair Martin, Meiling Gao, Riccardo Masina, Ramona Woitek, James Tanner, Fleur Tippin, Justine Kane, Jonathan Lay, Anja Brouwer, Stephen‐John Sammut, Suet‐Feung Chin, Davina Gale, Dana W. Y. Tsui, Sarah‐Jane Dawson, Nitzan Rosenfeld, Maurizio Callari, Oscar M. Rueda, Carlos Caldas   +20 more
wiley   +1 more source

Patient Data Sharing and Confidentiality Practices of Researchers in Jordan

Risk Management and Healthcare Policy, 2019
Reema A Karasneh,1 Sayer I Al-Azzam,2 Karem H Alzoubi,2 Sahar S Hawamdeh,2 Suhaib M Muflih2 1Department of Basic Medical Sciences, Faculty of Medicine, Yarmouk University, Irbid, Jordan; 2Department of Clinical Pharmacy, Faculty of Pharmacy, Jordan ...
Karasneh RA, Al-Azzam SI, Alzoubi KH, Hawamdeh SS, Muflih SM   +4 more
doaj  

ShcD adaptor protein drives invasion of triple negative breast cancer cells by aberrant activation of EGFR signaling

Molecular Oncology, EarlyView.
We identified adaptor protein ShcD as upregulated in triple‐negative breast cancer and found its expression to be correlated with reduced patient survival and increased invasion in cell models. Using a proteomic screen, we identified novel ShcD binding partners involved in EGFR signaling pathways.
Hayley R. Lau, Hayley S. Smith, Begüm Alural, Claire E. Martin, Laura A. New, Manali Tilak, Sara L. Banerjee, Hannah N. Robeson, Nicolas Bisson, Anne‐Claude Gingras, Jasmin Lalonde, Nina Jones   +11 more
wiley   +1 more source

MET and NF2 alterations confer primary and early resistance to first‐line alectinib treatment in ALK‐positive non‐small‐cell lung cancer

Molecular Oncology, EarlyView.
Alectinib resistance in ALK+ NSCLC depends on treatment sequence and EML4‐ALK variants. Variant 1 exhibited off‐target resistance after first‐line treatment, while variant 3 and later lines favored on‐target mutations. Early resistance involved off‐target alterations, like MET and NF2, while on‐target mutations emerged with prolonged therapy.
Jie Hu, Ning Ding, Xiaobo Xu, Yedan Chen, Yong Zhang, Jingwen Liu, Jiebai Zhou, Hairong Bao, Donghui Zhang, Yijun Song, Yang Shao, Yuanlin Song   +11 more
wiley   +1 more source

Determination of ADP/ATP translocase isoform ratios in malignancy and cellular senescence

Molecular Oncology, EarlyView.
The individual functions of three isoforms exchanging ADP and ATP (ADP/ATP translocases; ANTs) on the mitochondrial membrane remain unclear. We developed a method for quantitatively differentiating highly similar human ANT1, ANT2, and ANT3 using parallel reaction monitoring. This method allowed us to assess changes in translocase levels during cellular
Zuzana Liblova, Dominika Maurencova, Barbora Salovska, Marek Kratky, Tomas Mracek, Zuzana Korandova, Alena Pecinova, Pavla Vasicova, David Rysanek, Ladislav Andera, Ivo Fabrik, Rudolf Kupcik, Pavel Kashmel, Pinky Sultana, Vojtech Tambor, Jiri Bartek, Josef Novak, Marie Vajrychova, Zdenek Hodny   +18 more
wiley   +1 more source

کاربرد مدارک و اطلاعات پزشکی در تحقیقات از دیدگاه پژوهشگران

مدیریت اطلاعات سلامت, 2008
مقدمه: امروزه تحقیقات در علوم مختلف به عنوان ابزاری قدرتمند و شایان توجه جهت ارزیابی آخرین دستاوردهای علمی به كار می‌رود. مهم‌ترین ابزار راه‌گشای محققین در علوم پزشکی برای انجام تحقیقات، مدارك و اطلاعات پزشكی بیماران در بایگانی‌های بیمارستان‌ها می‌باشد ...
Sima Ajami, Faeze Kalbasi, Mahnaz Kabiri
doaj  

Patient-Empowered Electronic Health Records

Medinfo, 2019
Electronic Health Records (EHRs) constitute evidence of online health information management. Critical healthcare information technology (HIT) infrastructure facilitates health information exchange of 'modern' health systems.
Tony R. Sahama, Andrew Stranieri, K. Butler-Henderson   +2 more
semanticscholar   +1 more source