The role of histone modifications in transcription regulation upon DNA damage
FEBS Letters, EarlyView.This review discusses the critical role of histone modifications in regulating gene expression during the DNA damage response (DDR). By modulating chromatin structure and recruiting repair factors, these post‐translational modifications fine‐tune transcriptional programmes to maintain genomic stability.
Angelina Job Kolady, Siyao Wang
wiley +1 more source
International Journal of COPD, 2014 Amy Blakemore,1,2 Chris Dickens,3 Else Guthrie,2 Peter Bower,1 Evangelos Kontopantelis,1 Cara Afzal,2 Peter A Coventry4 1National Institute for Health Research School for Primary Care Research, Centre for Primary Care, Manchester Academic Health Science ...
Blakemore A +6 more
doaj
Higher self‐reported severity of atopic dermatitis in adults is associated with poorer self‐reported health‐related quality of life in France, Germany, the U.K. and the U.S.A. [PDF]
, 2019 Liv Øinæs Andersen +2 more
openalex +1 more source
Mechanisms of parasite‐mediated disruption of brain vessels
FEBS Letters, EarlyView.Parasites can affect the blood vessels of the brain, often causing serious neurological problems. This review explains how different parasites interact with and disrupt these vessels, what this means for brain health, and why these processes matter. Understanding these mechanisms may help us develop better ways to prevent or treat brain infections in ...
Leonor Loira +3 more
wiley +1 more source
Health-related quality of life in chronic obstructive pulmonary disease patients in Korea [PDF]
, 2014 Seon‐Ha Kim +2 more
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Effects of High Flow Nasal Cannula (HFNC) on Hospital Admissions and Health-Related Quality of Life (HRQoL) Measures in Severe COPD Patients [PDF]
, 2021 C. Theunisse +5 more
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Time after time – circadian clocks through the lens of oscillator theory
FEBS Letters, EarlyView.Oscillator theory bridges physics and circadian biology. Damped oscillators require external drivers, while limit cycles emerge from delayed feedback and nonlinearities. Coupling enables tissue‐level coherence, and entrainment aligns internal clocks with environmental cues.
Marta del Olmo +2 more
wiley +1 more source
Multiple ETS family transcription factors bind mutant p53 via distinct interaction regions
FEBS Letters, EarlyView.Mutant p53 gain‐of‐function is thought to be mediated by interaction with other transcription factors. We identify multiple ETS transcription factors that can bind mutant p53 and found that this interaction can be promoted by a PXXPP motif. ETS proteins that strongly bound mutant p53 were upregulated in ovarian cancer compared to ETS proteins that ...
Stephanie A. Metcalf +6 more
wiley +1 more source
Measuring quality of life in clinical research – Part 1
Perspectives in Clinical ResearchHealth-related quality of life (HRQOL) is increasingly being recognized as an important outcome for individuals, both as part of clinical care as well as in research, along with conventional outcomes like response or survival.
Priya Ranganathan +2 more
doaj +1 more source