Results 151 to 160 of about 4,692,109 (328)

Measuring quality of life in clinical research – Part 1

Perspectives in Clinical Research
Health-related quality of life (HRQOL) is increasingly being recognized as an important outcome for individuals, both as part of clinical care as well as in research, along with conventional outcomes like response or survival.
Priya Ranganathan, Jammbe Z Musoro, C. S. Pramesh   +2 more
doaj   +1 more source

Inhibiting stearoyl‐CoA desaturase suppresses bone metastatic prostate cancer by modulating cellular stress, mTOR signaling, and DNA damage response

FEBS Letters, EarlyView.
Bone metastasis in prostate cancer (PCa) patients is a clinical hurdle due to the poor understanding of the supportive bone microenvironment. Here, we identify stearoyl‐CoA desaturase (SCD) as a tumor‐promoting enzyme and potential therapeutic target in bone metastatic PCa.
Alexis Wilson, Mackenzie K Herroon, Shane Mecca, Laimar C Garmo, Jacob Lindquist, Shrila Rajendran, Steve M. Patrick, Izabela Podgorski   +7 more
wiley   +1 more source

Health-related quality of life in sandwich generation Iranian women

Family Medicine & Primary Care Review, 2021
Azadeh Zangenehpour, Parvin Abedi, Mojgan Javadnoori, Amal Malehi   +3 more
doaj   +1 more source

Analysis of Sociodemographic and Psychological Variables Involved in Sleep Quality in Nurses [PDF]

, 2019
Background: Sleep quality is related to health and quality of life and can lead to the development of related disorders. This study analyzed the sociodemographic and psychological factors related to sleep quality in nurses.
Gázquez Linares, José Jesús, Molero Jurado, María del Mar, Pérez Fuentes, María Del Carmen, Simón Márquez, María del Mar   +3 more
core   +1 more source

The (Glg)ABCs of cyanobacteria: modelling of glycogen synthesis and functional divergence of glycogen synthases in Synechocystis sp. PCC 6803

FEBS Letters, EarlyView.
We reconstituted Synechocystis glycogen synthesis in vitro from purified enzymes and showed that two GlgA isoenzymes produce glycogen with different architectures: GlgA1 yields denser, highly branched glycogen, whereas GlgA2 synthesizes longer, less‐branched chains.
Kenric Lee, Dimitrios Bekiari, Sofia Doello, Karl Forchhammer   +3 more
wiley   +1 more source

Health-Related Quality of Life [PDF]

Surgical Oncology Clinics of North America, 2018
Hannah Wiseman, Gemma Mercer, Roy C. Martin, Markus Reuber   +3 more
openaire   +2 more sources

Structural biology of ferritin nanocages

FEBS Letters, EarlyView.
Ferritin is a conserved iron‐storage protein that sequesters iron as a ferric mineral core within a nanocage, protecting cells from oxidative damage and maintaining iron homeostasis. This review discusses ferritin biology, structure, and function, and highlights recent cryo‐EM studies revealing mechanisms of ferritinophagy, cellular iron uptake, and ...
Eloise Mastrangelo, Flavio Di Pisa
wiley   +1 more source

Quality criteria for young people friendly health services [PDF]

, 2011
The Department of Health ‘Quality criteria for young people friendly health services’, which is referred to as ‘You’re Welcome’, sets out principles to help commissioners a nd service providers to improve the suitability of NHS and non-NHS health ...

core  

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

FEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

Measuring quality of life in clinical research - Part 2

Perspectives in Clinical Research
This article deals with the various aspects of health-related quality of life (QoL) assessments, building upon a previous discussion of the concept and its measurement types. Specifically, the article will delve into number and timing of QoL assessments,
Priya Ranganathan, Jammbe Z. Musoro, C. S. Pramesh   +2 more
doaj   +1 more source