Results 191 to 200 of about 4,692,109 (328)

Predictors of response and rational combinations for the novel MCL‐1 inhibitor MIK665 in acute myeloid leukemia

Molecular Oncology, EarlyView.
This study characterizes the responses of primary acute myeloid leukemia (AML) patient samples to the MCL‐1 inhibitor MIK665. The results revealed that monocytic differentiation is associated with MIK665 sensitivity. Conversely, elevated ABCB1 expression is a potential biomarker of resistance to the treatment, which can be overcome by the combination ...
Joseph Saad, Rhiannon Newman, Elmira Khabusheva, Sofia Aakko, Eric Durand, Mahesh Tambe, Heikki Kuusanmäki, Alun Parsons, Juho J. Miettinen, Komal Kumar Javarappa, Ezgi June Olgac, Nemo Ikonen, Mika Kontro, Kimmo Porkka, Heiko Maacke, Janghee Woo, Ensar Halilovic, Caroline A. Heckman   +17 more
wiley   +1 more source

Health-related quality of life of children with strabismus. [PDF]

Acta Ophthalmol
Boulakh L, Isaksen JL, Ellervik C, Kanters JK, Hesgaard HB, Sandfeldt L.   +5 more
europepmc   +1 more source

Development and validation of the expanded prostate cancer index composite (EPIC) for comprehensive assessment of health-related quality of life in men with prostate cancer.

Urology, 2000
John T. Wei, Rodney L Dunn, Rodney L Dunn, M. Litwin, H. Sandler, M. Sanda   +5 more
semanticscholar   +1 more source

Quality of Life Lost Due to Non-Fatal Road Crashes [PDF]

The objective of this paper is to evaluate the effect of a nonfatal road crash on the health-related quality of life of injured people. A new approach is suggested, based on the cardinalization of categorical Self-Assessed Health valuations.
Cubí-Mollá Patricia, Herrero Carmen
core  

Feasibility of a ctDNA multigenic panel for non‐small‐cell lung cancer early detection and disease surveillance

Molecular Oncology, EarlyView.
Plasma‐based detection of actionable mutations is a promising approach in lung cancer management. Analysis of ctDNA with a multigene NGS panel identified TP53, KRAS, and EGFR as the most frequently altered, with TP53 and KRAS in treatment‐naïve patients and TP53 and EGFR in previously treated patients.
Giovanna Maria Stanfoca Casagrande, Marcela de Oliveira Silva, Mariana Bisarro dos Reis, Rodrigo de Oliveira Cavagna, Luciane Sussuchi, Icaro Alves Pinto, Natalia Zampieri Pontes, Rodrigo Sampaio Chiarantano, Flavio Augusto Ferreira da Silva, Pedro de Marchi, Letícia Ferro Leal, Rui M. Reis   +11 more
wiley   +1 more source

Health-related quality of life after HPB surgery. [PDF]

Surg Open Sci
Zaydfudim VM.
europepmc   +1 more source

Cost-Benefit Model System of Chronic Diseases in Australia to Assess and Rank Prevention and Treatment Options [PDF]

Chronic diseases - eg heart disease, cancer, diabetes, mental disorders - affect around 80% of older Australians, are the main causes of disability and premature death, and account for 70% of total health expenditures.
Agnes E. Walker, Stephen Colagiuri
core  

Aggressive prostate cancer is associated with pericyte dysfunction

Molecular Oncology, EarlyView.
Tumor‐produced TGF‐β drives pericyte dysfunction in prostate cancer. This dysfunction is characterized by downregulation of some canonical pericyte markers (i.e., DES, CSPG4, and ACTA2) while maintaining the expression of others (i.e., PDGFRB, NOTCH3, and RGS5).
Anabel Martinez‐Romero, Ane Martinez‐Larrinaga, Joaquim Grego‐Bessa, Saioa Garcia‐Longarte, Hielke van Splunder, Ianire Astobiza, Amaia Ercilla, Laura Bozal‐Basterra, Isabel Mendizabal, Pilar Villacampa, Arkaitz Carracedo, Mariona Graupera   +11 more
wiley   +1 more source

The neural crest‐associated gene ERRFI1 is involved in melanoma progression and resistance toward targeted therapy

Molecular Oncology, EarlyView.
ERRFI1, a neural crest (NC)‐associated gene, was upregulated in melanoma and negatively correlated with the expression of melanocytic differentiation markers and the susceptibility of melanoma cells toward BRAF inhibitors (BRAFi). Knocking down ERRFI1 significantly increased the sensitivity of melanoma cells to BRAFi.
Nina Wang, Qian Sun, Daniel Novak, Lei Zhu, Juliane Poelchen, Tamara Steinfass, Yiman Wang, Viktor Umansky, Jochen Utikal   +8 more
wiley   +1 more source

Associations of taste sensitivity with frailty and health-related quality of life in older adults. [PDF]

J Nutr Health Aging
Kato S, Baden MY, Yamabayashi E, Kawamoto S, Kagisaki T, Mitsushio K, Beppu AN, Nagai N, Horii T, Ishibashi C, Hosokawa Y, Takahara M, Kozawa J, Nishizawa H, Takeda T, Yamaga S, Kudoh M, Kurita D, Kuboniwa M, Shimomura I.   +19 more
europepmc   +1 more source