Results 201 to 210 of about 81,170,443 (266)

Identifying practices for meaningful health research partnerships: series of rapid environmental scans. [PDF]

Res Involv Engagem
Shwed A, Finlay LM, Holliday PG, Brar K, Lambrecht M, Giroux EE, Shaikh M, Skinner C, Hoekstra F, Sibley KM, Chernesky J, McBride CB, Willms R, Kaiser A, Creighton G, Plamondon K, Claydon VE, Sweet SN, IKT Guiding Principles Partnership, Gainforth HL.   +19 more
europepmc   +1 more source

Comparing the paths of Hedgehog release in artificial and natural settings

FEBS Letters, EarlyView.
Hh morphogens require solubilization factors to overcome their tight association with the plasma membrane and signal to distant cells, but the precise functions of these factors are controversial. Here, we use published in vivo observations as the most relevant evidence to test their suggested functions and discuss contradictions and gaps between in ...
Janna Puschmann, Kay Grobe
wiley   +1 more source

How structural disorder and polyelectrolyte properties of prothymosin α enable its large interactome

FEBS Letters, EarlyView.
In this review, complexes of the fully disordered and highly negatively charged prothymosin α are collected, described, and discussed. Linked to its poly‐electrostatic character, prothymosin α engages a large interactome through multiple different binding modes ranging from fully disordered complexes to short linear motif (SLiM)‐driven interactions ...
Ketty C. Tamburrini, Freia S. Buus, Benjamin Schuler, Birthe B. Kragelund   +3 more
wiley   +1 more source

Reflecting on Youth Participation in Mental Health Research: Lessons From the Consell de Joves in Catalonia. [PDF]

Health Expect
Bennett M, Lozano-Sánchez A, Guzmán-Molina C, Jacques-Aviñó C.   +3 more
europepmc   +1 more source

Editorial: Encouraging health research productivity in complex humanitarian crises: Somalia

Frontiers in Public Health
Abdi Gele, Amina Jama Mahmud, Bernadette Nirmal Kumar, Cynthia Khamala Wangamati, Hodan A. Duale, Mamunur Rahman Malik, Mekdes Gebremariam, Ragnhild Dybdahl   +7 more
doaj   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer

Molecular Oncology, EarlyView.
Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley   +1 more source

Editorial: Advancing biostatistics and informatics applications in mental health research. [PDF]

Front Psychiatry
Zeng IS, Kessler R.
europepmc   +1 more source

Developmental programmes drive cellular plasticity, disease progression and therapy resistance in lung adenocarcinoma

Molecular Oncology, EarlyView.
This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska, Stephany Gallardo, Nur S. Zainal, Leena Arora, Matthew Ellis, Maria‐Antoinette Lopez, Judith Austine, Sai Pittla, Serena J Chee, Aiman Alzetani, Emily C Shaw, Christian H Ottensmeier, Gareth J Thomas, Christopher J Hanley   +13 more
wiley   +1 more source

"What about that violence?" Transforming the discourse on violence in mental health research and services. [PDF]

Front Psychiatry
Leclair M, Lemieux AJ, Crocker AG, Dumais Michaud AA, Perrottet D, Vigneault L, Brabant C, Péloquin S, Roy L.   +8 more
europepmc   +1 more source