Results 231 to 240 of about 65,601,074 (263)

Challenges and facilitators for meaningful and impactful stakeholder engagement in global health research. [PDF]

J Glob Health
Adnani QES, Fernandes G, Kinley E, Williams S.   +3 more
europepmc   +1 more source

Inhibition of cyclin‐dependent kinases 12/13 using CT7439 as a treatment for colorectal cancer with CDK12 upregulation

Molecular Oncology, EarlyView.
The proposed mechanism of action for the CDK12/13 inhibitor and cyclin K degrader, CT7439. CDK12/13 inhibition interrupts transcription elongation, leading to increased DNA damage that results in cell death. This agent is a potentially novel treatment option for patients with colorectal cancer. Created in BioRender. Cyclin‐dependent kinase (CDK) 12 and
Wylie K. Watlington, Divya L. Dayanidhi, Mohammad Zokaasadi, John B. Mantyh, Pelumi D. Olawuni, Gabrielle Rupprecht, Jeremy M. Force, Shannon McCall, Ashwani K. Bahl, David S. Hsu, Jason A. Somarelli   +10 more
wiley   +1 more source

Bridging assessment, biomarkers, and interventions: progress in muscle health research. [PDF]

Front Rehabil Sci
Oranchuk DJ, DeFreitas JM, Nelson AR, Harris-Love MO.   +3 more
europepmc   +1 more source

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

Molecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq, Marc Terrones, Felicia Rodrigues Fortes, Anne Schepers, Alessia Denis, Christophe Deben, Ken Op de Beeck, Guy Van Camp, Geert Vandeweyer   +8 more
wiley   +1 more source

Relevance and challenges of exposome studies for environmental health research. [PDF]

Environ Health
Slama R, Siroux V, Vrijheid M, Basagaña X.   +3 more
europepmc   +1 more source

The Dutch Nationwide Pathology Databank and its central role in health research. [PDF]

J Pathol Inform
Siebers AG, Voorham QJM, Kuijpers CCHJ, Bruggink AH, Seegers PA, van den Broek EC, Hoogeveen M, van den Brand M, van Deurzen CHM, Kibbelaar RE.   +9 more
europepmc   +1 more source

MyBioScope: a new frontier in gut microbiome and health research. [PDF]

Bioresour Bioprocess
Žukauskaitė K, Horvath A, Tripolt S, Habisch H, Madl T, Pacher-Deutsch C, Nepel M, Balazs I, Stadlbauer V.   +8 more
europepmc   +1 more source

Citizen Science in Air Pollution Monitoring: Methodological Approaches, Effectiveness, and Integration with Health Research. [PDF]

Curr Environ Health Rep
Yang H.
europepmc   +1 more source

Artificial Intelligence in Food-Nutrition-Health Research: From Multimodal Data Integration to Precision Intervention. [PDF]

J Food Sci
Wu X, Feng J.
europepmc   +1 more source