Results 51 to 60 of about 1,905,976 (313)

Türkiye's Health Profile: Health Indicators and Cluster Analysis by Provinces

Sağlık ve Hemşirelik Yönetimi Dergisi
Aim: This study aims to classify the provinces in Turkey based on health indicators in the context of health resources. Method: Eleven health variables were determined in line with the study's objective, and data from the Turkish Statistical Institute ...
Melek Yağcı Özen
doaj   +1 more source

The role and implications of mammalian cellular circadian entrainment

FEBS Letters, EarlyView.
At their most fundamental level, mammalian circadian rhythms occur inside every individual cell. To tell the correct time, cells must align (or ‘entrain’) their circadian rhythm to the external environment. In this review, we highlight how cells entrain to the major circadian cues of light, feeding and temperature, and the implications this has for our
Priya Crosby
wiley   +1 more source

International comparison of health care systems using resource profiles

Bulletin of the World Health Organization, 2000
The most frequently used bases for comparing international health care resources are health care expenditures, measured either as a fraction of gross domestic product (GDP) or per capita.
Anders Anell, Michael Willis
doaj  

Crosstalk between the ribosome quality control‐associated E3 ubiquitin ligases LTN1 and RNF10

FEBS Letters, EarlyView.
Loss of the E3 ligase LTN1, the ubiquitin‐like modifier UFM1, or the deubiquitinating enzyme UFSP2 disrupts endoplasmic reticulum–ribosome quality control (ER‐RQC), a pathway that removes stalled ribosomes and faulty proteins. This disruption may trigger a compensatory response to ER‐RQC defects, including increased expression of the E3 ligase RNF10 ...
Yuxi Huang, Satoshi Hashimoto, Sota Ito, Chisato Kikuguchi, Miho Hoshi, Kiyoshi Yamaguchi, Yoichi Furukawa, Toru Suzuki, Toshifumi Inada   +8 more
wiley   +1 more source

An Integrated Analysis of the Perceptions of Health Care Users, Professionals, and Managers in Catalonia

Forum: Qualitative Social Research, 2009
The increased demand for health services and the inclusion of new aspects in what is culturally considered "health and health care" represent a significant challenge for the current health care system and health care practice model in Catalonia ...
Lupicinio Iñiguez, Jordi Sanz, Pilar Monreal, Arantza Del Valle, Josep Fusté   +4 more
doaj  

The impact of reduced pediatric emergency care hours on the patterns of emergency department utilization [PDF]

Pediatric Emergency Medicine Journal
Purpose : The declining recruitment rate of pediatric residents in Korea has led to a decrease in the number of emergency departments (EDs) offering a 24/7 pediatric emergency care (PEC).
Seung Ho Hur, Hyun Soo Choi, Jun Suk Oh, Seong Soo Park, Jae Kwang Lee   +4 more
doaj   +1 more source

Function‐driven design of a surrogate interleukin‐2 receptor ligand

FEBS Letters, EarlyView.
Interleukin (IL)‐2 signaling can be achieved and precisely fine‐tuned through the affinity, distance, and orientation of the heterodimeric receptors with their ligands. We designed a biased IL‐2 surrogate ligand that selectively promotes effector T and natural killer cell activation and differentiation. Interleukin (IL) receptors play a pivotal role in
Ziwei Tang, Zelin Cheng, Teng Li, Fulian Wang, Liangminghui Zhang, Xiuxiu He, Lili Liu, Wei Wang, Aibin Liang, Guang Yang   +9 more
wiley   +1 more source

In situ molecular organization and heterogeneity of the Legionella Dot/Icm T4SS

FEBS Letters, EarlyView.
We present a nearly complete in situ model of the Legionella Dot/Icm type IV secretion system, revealing its central secretion channel and identifying new components. Using cryo‐electron tomography with AI‐based modeling, our work highlights the structure, variability, and mechanism of this complex nanomachine, advancing understanding of bacterial ...
Przemysław Dutka, Yuxi Liu, Stefano Maggi, Debnath Ghosal, Jue Wang, Prashant P. Damke, Stephen D. Carter, Wei Zhao, Sukhithasri Vijayrajratnam, Joseph P. Vogel, Carrie L. Shaffer, Grant J. Jensen   +11 more
wiley   +1 more source

Cost Considerations in Healthcare: Review Analysis of Break-even Point of Spirometry [PDF]

Journal of Clinical and Diagnostic Research
For financial sustainability and service-based efficiency in healthcare services, there is a need for better understanding and application of cost analysis, Break-even Point (BEP) analysis, and Cost-benefit Analysis (CBA).
Ankanahalli Ramu Somashekhar, V Nancy Jeniffer, K Sindhu, Da Chirag, Smitha R Chandra   +4 more
doaj   +1 more source

Cell wall target fragment discovery using a low‐cost, minimal fragment library

FEBS Letters, EarlyView.
LoCoFrag100 is a fragment library made up of 100 different compounds. Similarity between the fragments is minimized and 10 different fragments are mixed into a single cocktail, which is soaked to protein crystals. These crystals are analysed by X‐ray crystallography, revealing the binding modes of the bound fragment ligands.
Kaizhou Yan, Mathew Stanley, Olawale Raimi, Andrew T. Ferenbach, Helge C Dorfmueller, Daan M. F. van Aalten   +5 more
wiley   +1 more source