Results 91 to 100 of about 4,224,464 (309)
Tau acetylation at K331 has limited impact on tau pathology in vivo
FEBS Letters, EarlyView.We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto +3 more
wiley +1 more source
Muslim immigrant women's experiences of mental health challenges in Southern Alberta, Canada
The purpose of this study was to explore the experiences of mental health challenges in Muslim immigrant women in Southern Alberta. Exploratory descriptive qualitative research design and semi-structured interviews with ten Muslim women were employed ...
Hosseinpour, Zohreh +1 more
core
Archiving Scholarship in an Institutional Repository (IR)
, 2021 What is an Institutional Repository (IR) and how can it be used to help promote the visibility of your research? In this brief session, we’ll discuss how to archive items in Health Sciences Research Commons (HSRC), the institutional repository for The ...
George Washington University, Himmelfarb Health Sciences Library
core
Calpain small subunit homodimerization is robust and calcium‐independent
FEBS Letters, EarlyView.Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy +4 more
wiley +1 more source
STAR ProtocolsSummary: Here, we present a protocol for implementing the nested model for developing and validating artificial intelligence (AI) systems in compliance with AI regulations.
Akshat Dubey +3 more
doaj +1 more source
Structural insights into an engineered feruloyl esterase with improved MHET degrading properties
FEBS Letters, EarlyView.A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa +5 more
wiley +1 more source
Fitness or socializing - A multi-dimensional analysis of online fitness communities users
iScienceSummary: The digital and social network revolution in the fitness industry will provide consumers with opportunities to achieve their healthy and active lifestyle goals both online and offline.
Lei Wang +3 more
doaj +1 more source
Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system
FEBS Letters, EarlyView.Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley +1 more source
Revista de la Facultad de Ciencias de la Salud, 2012 It seems obvious, but for teaching in health sciences faculties, it is not enough to be a doctor or specialist. In fact, “medical education” is taught as a specialty in many universities of the country.
Mario Delgado-Noguera
doaj
Advances in nanoparticle-based radiotherapy for cancer treatment
iScienceSummary: Radiotherapy has long been recognized as an effective conventional approach in both clinical and scientific research, primarily through mechanisms involving DNA destruction or the generation of reactive oxygen species to target tumors.
Meijuan He +7 more
doaj +1 more source