Results 241 to 250 of about 16,695,831 (404)

Loss of proton‐sensing GPR4 reduces tumor progression in mouse models of colon cancer

Molecular Oncology, EarlyView.
G protein‐coupled receptor 4 (GPR4) is a pH‐sensing receptor activated by acidic pH. GPR4 expression is increased in patients with inflammatory bowel disease who are at high risk of developing colorectal cancer. In mouse models, loss of GPR4 attenuated tumor progression. This correlated with increased IL2 and natural killer cell activity.
Leonie Perren, Moana Busch, Pedro A. Ruiz, Ermanno Malagola, Valeria Baumeler, Federica Foti, Adelina Gross, Tobias Grütter, Hendrik Edel, Cordelia Schuler, Kristina Handler, Glenn De Lange, Isabelle C. Arnold, Cheryl de Vallière, Klaus Seuwen, Martin Hausmann, Gerhard Rogler   +16 more
wiley   +1 more source

TRPM8 levels determine tumor vulnerability to channel agonists

Molecular Oncology, EarlyView.
TRPM8 is a Ca2+ permissive channel. Regardless of the amount of its transcript, high levels of TRPM8 protein mark different tumors, including prostate, breast, colorectal, and lung carcinomas. Targeting TRPM8 with channel agonists stimulates inward calcium currents followed by emptying of cytosolic Ca2+ stores in cancer cells.
Alessandro Alaimo, Francesco Giuseppe Carbone, Kristi Buzo, Nicole Annesi, Sacha Genovesi, Annalisa Lorenzato, Karen Widmann, Michela Libergoli, Elisa Marmocchi, Giovanni Bertalot, Alberto Brolese, Mauro Giulio Papotti, Luca Molinaro, Orazio Caffo, Mattia Barbareschi, Alberto Bardelli, Alessandro Romanel, Sabrina Arena, Andrea Lunardi   +18 more
wiley   +1 more source

Sentient Intercultural Self-Efficacy: Constructing Intercultural Competence in Health Sciences students. [PDF]

J Adv Med Educ Prof
Álvarez-Cruces D, Mansilla-Sepúlveda J, Nocetti-DE-LA-Barra A.   +2 more
europepmc   +1 more source

Early Management and Decision-Making for the Treatment of Myelomeningocele at the University of Oklahoma Health Sciences Center: Observations Clinical and Ethical

, 1986
Michael E. Allsopp
openalex   +2 more sources

Research Digest - March 2018 [PDF]

, 2018
Division of Public Health Sciences, Department of Surgery, Washington University School of Medicine in St. Louis
core   +1 more source

The anticancer effect of the HDAC inhibitor belinostat is enhanced by inhibitors of Bcl‐xL or Mcl‐1 in ovarian cancer

Molecular Oncology, EarlyView.
The pan‐HDAC inhibitor belinostat increases the expression of the pro‐apoptotic proteins Bim, Puma, and Noxa and induces apoptosis in ovarian cancer cell lines and patient‐derived tumor organoids when used at high concentrations. Moreover, inhibiting the anti‐apoptotic proteins Bcl‐xL or Mcl‐1 sensitizes these preclinical models to the cytotoxic effect
Cécilia Thomine, Sterenn Guillemot, Louis‐Bastien Weiswald, Romane Florent, Edwige Abeilard, Florence Giffard, Emilie Brotin, Mélanie Briand, Enora Dolivet, Laurent Poulain, Marie Villedieu   +10 more
wiley   +1 more source

Non-clinician involvement in interprofessional health sciences education: educator experiences and attitudes. [PDF]

J Med Libr Assoc
Helbing RR, Hausmann RC.
europepmc   +1 more source

Federally-supported human nutrition research, training, and education: update for the 1980s. I. Human nutrition research and training. Prepared by the Joint Subcommittee on Human Nutrition Research of the Committee on Health and Medicine and the Committee on Food and Renewable Resources. Federal Coordinating Council on Science, Engineering, and Technology. Office of Science and Technology Policy. Executive Office of the President

, 1981

openalex   +1 more source

Total Quality Management at the Walter C Mackenzie Health Sciences Centre: Positive Experience of the Division of Gastroenterology [PDF]

, 1994
ABR Thomson, Lucas Walz, Kim Sutherland
openalex   +1 more source

Research Digest - September 2017 [PDF]

, 2017
Division of Public Health Sciences, Department of Surgery, Washington University School of Medicine in St. Louis
core   +1 more source