Results 271 to 280 of about 7,174,113 (351)

Somatic mutational landscape in von Hippel–Lindau familial hemangioblastoma

open access: yesMolecular Oncology, EarlyView.
The causes of central nervous system (CNS) hemangioblastoma in Von Hippel–Lindau (vHL) disease are unclear. We used Whole Exome Sequencing (WES) on familial hemangioblastoma to investigate events that underlie tumor development. Our findings suggest that VHL loss creates a permissive environment for tumor formation, while additional alterations ...
Maja Dembic   +5 more
wiley   +1 more source

Research Digest - July 2018 [PDF]

open access: yes, 2018
Division of Public Health Sciences, Department of Surgery, Washington University School of Medicine in St. Louis
core   +1 more source

Dual PI3K/AKT and CDK4/6 inhibition reveals selective sensitivity in an SHH medulloblastoma stem cell model

open access: yesMolecular Oncology, EarlyView.
Targeted therapy was evaluated in SHH medulloblastoma using neuroepithelial stem cell (NES) and tumor‐derived NES‐like (tNES) models in 2D monolayers and 3D spheroids. PI3K, AKT, and CDK4/6 inhibitors had minimal effects in NES but markedly reduced viability and growth and induced apoptosis in tNES cells, revealing distinct therapeutic vulnerabilities.
Monika Lukoseviciute   +4 more
wiley   +1 more source

Transcultural validation and factorial invariance assessment of the EEA Resilience Scale in health sciences students from eight Latin American countries. [PDF]

open access: yesPsicol Reflex Crit
Gamarra-Moncayo J   +25 more
europepmc   +1 more source

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

open access: yesMolecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric   +10 more
wiley   +1 more source

Undergraduate health sciences students' perceptions and practices of evidence-based practice: a cross-sectional study in Saudi Arabia. [PDF]

open access: yesBMC Med Educ
Alharbi B   +7 more
europepmc   +1 more source

Research Digest - December 2017 [PDF]

open access: yes, 2017
Division of Public Health Sciences, Department of Surgery, Washington University School of Medicine in St. Louis
core   +1 more source

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