Results 61 to 70 of about 1,366,440 (219)

KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer

Molecular Oncology, EarlyView.
Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan, Veronika M Metzler, Simone de Brot, Corinne L Woodcock, Anna E Harris, Jennifer Lothion‐Roy, Emeli M Nilsson, Atara Ntekim, Michael S Toss, Jenny L Persson, Francesca Khani, Brian D Robinson, Lorraine J Gudas, Emad Rakha, David M Heery, Catrin S Rutland, Nigel P Mongan   +16 more
wiley   +1 more source

Physician contact by older Asian Americans: the effects of perceived mental health need

Clinical Interventions in Aging, 2010
Duy NguyenSilver School of Social Work, New York University, New York, NY, USAObjective: The use of physicians is more common than of behavioral specialists, especially in underserved Asian American communities.
Duy Nguyen
doaj  

Transcriptional profiling of circulating extracellular vesicles from prebiopsy prostate cancer patients

Molecular Oncology, EarlyView.
RNA profiling of circulating extracellular vesicles (EVs) from blood samples of men undergoing prostate biopsy identifies transcripts associated with clinically significant prostate cancer. Integrative analysis with public tumor datasets links EV‐derived gene signatures to tumor stage and progression‐free survival, highlighting CASP3, XRCC2, and RIT1 ...
Stefan Werner, Pierre Tennstedt, Randi C. Pose, Christian Müller, Katharina Besler, Svenja Schneegans, Malik Alawi, Marie C. Roesch, Sven Peine, Desiree Bonci, Joanna Budna‐Tukan, Evi Lianidou, Catherine Alix‐Panabières, Derya Tilki, Klaus Pantel   +14 more
wiley   +1 more source

Developmental programmes drive cellular plasticity, disease progression and therapy resistance in lung adenocarcinoma

Molecular Oncology, EarlyView.
This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska, Stephany Gallardo, Nur S. Zainal, Leena Arora, Matthew Ellis, Maria‐Antoinette Lopez, Judith Austine, Sai Pittla, Serena J Chee, Aiman Alzetani, Emily C Shaw, Christian H Ottensmeier, Gareth J Thomas, Christopher J Hanley   +13 more
wiley   +1 more source

Laboratory Test Use and Values in the Last Year of Life—a Matched Cohort Design

Canadian Geriatrics Journal
Background As individuals approach death, they experience declines in their cognitive, physical, motor, sensory, physiologic, and psychosocial functions.
Rhiannon L. Roberts, Haris Imsirovic, Robert Talarico, Wenshan Li, André Carrington, Kruti Patel, Douglas Manuel, Peter Tanuseputro, Steven Hawken, Colleen Webber   +9 more
doaj   +1 more source

Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining

Molecular Oncology, EarlyView.
IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis, Jack V. Mills, Wojciech Niedzwiedz, Valentine M. Macaulay   +3 more
wiley   +1 more source

Differences in the Management and Use of Health Services in Australia Using Publicly Available Data: Comparisons between New South Wales and Victoria

Asia Pacific Journal of Health Management
Introduction: Differences in health service utilisation between States are noted in publicly reported data. The national averages for health service usage and health related actions in Australia may mask differences in the management and provision of ...
Jo M Martins, Godfrey Isouard
doaj  

Long-term ambulance, emergency, and hospital use following mine fire-related PM2.5 exposure: analysis of linked data

Environmental Research: Health
Background. The 2014 Hazelwood coal mine fire shrouded the regional Victoria, Australia town of Morwell in smoke for six weeks. Building on previous analyses, we explored linked survey and healthcare data to investigate longer-term effects of fire ...
Tyler J Lane, Caroline X Gao, Catherine L Smith, Jillian F Ikin, Rongbin Xu, Matthew T C Carroll, Emily Nehme, Natasha Kinsman, Thara Govindaraju, Michael J Abramson, Karen Walker-Bone, Yuming Guo   +11 more
doaj   +1 more source

Study protocol for a pragmatic trial of the Consult for Addiction Treatment and Care in Hospitals (CATCH) model for engaging patients in opioid use disorder treatment

Addiction Science & Clinical Practice, 2019
Background Treatment for opioid use disorder (OUD) is highly effective, yet it remains dramatically underutilized. Individuals with OUD have disproportionately high rates of hospitalization and low rates of addiction treatment.
Jennifer McNeely, Andrea B. Troxel, Hillary V. Kunins, Donna Shelley, Joshua D. Lee, Alexander Walley, Zoe M. Weinstein, John Billings, Nichola J. Davis, Roopa Kalyanaraman Marcello, Bruce R. Schackman, Charles Barron, Luke Bergmann   +12 more
doaj   +1 more source

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

Molecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq, Marc Terrones, Felicia Rodrigues Fortes, Anne Schepers, Alessia Denis, Christophe Deben, Ken Op de Beeck, Guy Van Camp, Geert Vandeweyer   +8 more
wiley   +1 more source