Results 121 to 130 of about 5,632,643 (360)

Mitochondria‐associated membranes (MAMs): molecular organization, cellular functions, and their role in health and disease

FEBS Open Bio, EarlyView.
Mitochondria‐associated membranes (MAMs) are contact sites between the endoplasmic reticulum and mitochondria that regulate calcium signaling, lipid metabolism, autophagy, and stress responses. This review outlines their molecular organization, roles in cellular homeostasis, and how dysfunction drives neurodegeneration, metabolic disease, cancer, and ...
Viet Bui, Maryline Santerre, Natalia Shcherbik, Bassel E Sawaya   +3 more
wiley   +1 more source

Geno4ME Study: implementation of whole genome sequencing for population screening in a large healthcare system

npj Genomic Medicine
The Genomic Medicine for Everyone (Geno4ME) study was established across the seven-state Providence Health system to enable genomics research and genome-guided care across patients’ lifetimes. We included multi-lingual outreach to underrepresented groups,
Isabelle A. Lucas Beckett, Kate R. Emery, Josiah T. Wagner, Kathleen Jade, Benjamin A. Cosgrove, John Welle, JB Rinaldi, Lindsay Dickey, Kyle Jones, Nick Wagner, Eric M. Shull, Jon Clemens, Kalliopi Trachana, Lance Anderson, Allison Kudla, Brett Smith, Hakon Verespej, Li Chi Yuan, Elizabeth Denne, Erica Ramos, Jennifer C. Lovejoy, Krzysztof Olszewski, Martin G. Reese, Misty J. Reynolds, Mandy M. Miller, Alexa K. Dowdell, Brianna Beck, James M. Scanlan, Mary B. Campbell, Andrew T. Magis, Keri Vartanian, Brian D. Piening, Carlo B. Bifulco, Ora K. Gordon   +33 more
doaj   +1 more source

Identifying Higher-Volume Antibiotic Outpatient Prescribers Using Medicare Part D Prescription Data — Arizona, 2021

Antimicrobial Stewardship & Healthcare Epidemiology
Background: Increased antibiotic resistance is a rising global health problem that can result from overprescribing and misusing antibiotics. The impact of antibiotic overprescribing is significant, particularly among the older adult population due to ...
Swathi Vajrala, Rachana Bhattarai, Tho Pham, Mandana Naderi, Celine Sanchez, Elizabeth Kim, Kenneth Komatsu   +6 more
doaj   +1 more source

The Reported Incidence of Glandular Fever: An Analysis of a Report of the Public Health Laboratory Service [PDF]

, 1957
Kenneth W. Newell
openalex   +1 more source

Tryptophan metabolite atlas uncovers organ, age, and sex‐specific variations

FEBS Open Bio, EarlyView.
Tryptophan metabolites were analyzed across twelve organs, the central nervous system, and serum in male and female mice at three life stages. We found tissue‐, sex‐, and age‐specific differences, including increased indole‐3‐pyruvate and kynurenine in aging males.
Lizbeth Perez‐Castro, Afshan F. Nawas, Jessica A. Kilgore, Pedro A. S. Nogueira, M.Carmen Lafita‐Navarro, Paul H. Acosta, Roy Garcia, Noelle S. Williams, Maralice Conacci‐Sorrell   +8 more
wiley   +1 more source

Lactoferrin treatment activates acetylcholinesterase, decreasing acetylcholine levels in non‐small cell lung cancer (NSCLC) cell culture supernatants, inhibiting cell survival

FEBS Open Bio, EarlyView.
Representation of the suggested mode of action of lactoferrin (Lf) in nonsmall cell lung cancer (NSCLC) A549 cells. Lf induces activation of caspase‐3 by activating p53 and AChE leading to decreased ACh concentrations. In turn, ACh signaling leads to activation of VEGF and AKT and blocking of caspase‐3.
Stuti Goel, Caroline Wozniak, Aya Sabri, Ben Haddad, Brooke Lopo, Alvaro Cobos, Sarah Sarofim, Jeffrey Guthrie, Deborah Heyl, Hedeel Guy Evans   +9 more
wiley   +1 more source

Women's Health Coverage Since the ACA: Improvements for Most, But Insurer Exclusions Put Many at Risk [PDF]

, 2016
Since enactment of the Affordable Care Act (ACA), many more women have health insurance than before the law, in part because it prohibits insurer practices that discriminate against women. However, gaps in women's health coverage persist.
Dania Palanker, Karen Davenport
core  

ATG4B is required for mTORC1‐mediated anabolic activity and is associated with clinical outcomes in non‐small cell lung cancer

FEBS Open Bio, EarlyView.
The relationship between anabolic and catabolic processes governing lung cancer cell growth is nuanced. We show that ATG4B, an autophagy regulator, is elevated in lung cancer and that high ATG4B is associated with worse patient outcomes. Targeting ATG4B in cells reduces growth, protein synthesis, and mTORC1 activity, demonstrating a new relationship ...
Patrick J. Ryan, Bethany C. Guerra, Selina Uranga, Jessica M. Cardin, Steven E. Riechman, Mariana Janini Gomes, James D. Fluckey   +6 more
wiley   +1 more source

Care in mind : improving the mental health of children and young people in state care in Scotland [PDF]

, 2004
Some five thousand children and young people are in residential and foster care in Scotland. Many experience poor outcomes and concern about the quality of care has led to a number of government initiatives including the registration of care services and
Furnivall, Judy, Kendrick, Andrew, Milligan, Ian   +2 more
core  

Diabetes‐induced vascular calcification is associated with low pyrophosphate and its oral supplementation prevents calcification in diabetic mice

FEBS Open Bio, EarlyView.
Induction of diabetes in three different mouse strains uniformly resulted in an increase in TNAP activity and a reduction in pyrophosphate (PPi) in the circulation. Inhibition of TNAP restored plasma PPi. Diabetes‐induced calcification in the media layer of the aorta was detected only in the Abcc6−/− strain, which is predisposed to ectopic ...
Krisztina Fülöp, Eszter Kozák, Natália Tőkési, Lilian Kocsis, Anikó Kelemen, Zsuzsanna Geszti, Adriána Kutás, Mariann Harangi, Ágnes Diószegi, Zsolt Rapi, József Balla, Olivier Le Saux, András Váradi, Viola Pomozi   +13 more
wiley   +1 more source