Results 121 to 130 of about 17,124,068 (312)

Geno4ME Study: implementation of whole genome sequencing for population screening in a large healthcare system

npj Genomic Medicine
The Genomic Medicine for Everyone (Geno4ME) study was established across the seven-state Providence Health system to enable genomics research and genome-guided care across patients’ lifetimes. We included multi-lingual outreach to underrepresented groups,
Isabelle A. Lucas Beckett, Kate R. Emery, Josiah T. Wagner, Kathleen Jade, Benjamin A. Cosgrove, John Welle, JB Rinaldi, Lindsay Dickey, Kyle Jones, Nick Wagner, Eric M. Shull, Jon Clemens, Kalliopi Trachana, Lance Anderson, Allison Kudla, Brett Smith, Hakon Verespej, Li Chi Yuan, Elizabeth Denne, Erica Ramos, Jennifer C. Lovejoy, Krzysztof Olszewski, Martin G. Reese, Misty J. Reynolds, Mandy M. Miller, Alexa K. Dowdell, Brianna Beck, James M. Scanlan, Mary B. Campbell, Andrew T. Magis, Keri Vartanian, Brian D. Piening, Carlo B. Bifulco, Ora K. Gordon   +33 more
doaj   +1 more source

Engineering IL‐4 resistant proinflammatory human myeloid cells for cancer immunotherapy

Molecular Oncology, EarlyView.
We developed a scalable workflow to generate proinflammatory human myeloid cells. CRISPR/Cas9‐edited CD34+ hematopoietic stem and progenitor cells were expanded and differentiated with M‐CSF. Deletion of STAT6 or STAT6/NFKB1 enhanced macrophage proinflammatory gene expression and cytokine secretion in the presence of IL‐4 while maintaining antibody ...
Theresa Barberi, Alan D. Friedman
wiley   +1 more source

Aboriginal and Torres Strait Islander health organisations: online services report - key results 2013-14 [PDF]

, 2015
This sixth national report provides an overview of 269 Australian Government-funded organisations that aim to improve the health of Aboriginal and Torres Strait Islander people. It presents findings from the 2013-14 Online Services Report data collection,
Australian Institute of Health and Welfare
core  

Integrated access to cancer screening: expanding access for cervical and colorectal cancer screening in rural and remote Northern Alberta, Canada using a mobile service to bring cancer screening closer to home

BMC Health Services Research
Background The goal of the Integrated Access to Cancer Screening (IACS) initiative was to help reduce the disparity in cancer screening participation across Alberta by implementing an integrated mobile service delivery model for breast, cervical, and ...
Jessica Wiseman, Kara Patterson, Gordon Kliewer, Mary Mueller, Seema Mutti-Packer, James Newsome, Stacy Lockerbie, Joan Hauber, Monica Schwann, Huiming Yang   +9 more
doaj   +1 more source

USP7 inhibits FOXO1 activity in chronic lymphocytic leukaemia cells enhancing cell survival

Molecular Oncology, EarlyView.
CLL cells rely on BCR‐mediated signalling for survival and proliferation in part through suppression of FOXO1. FOXO1 activity is regulated by a plethora of post‐translational modifications including phosphorylation and ubiquitination. We demonstrated that dual inhibition of BCR signalling and the deubiquitinase USP7 activates FOXO1, modulating its ...
Hassan N.B. Almuhanna, Jodie Hay, Michael W. Moles, Lucy Clarke, Jennifer Cassels, Alison Sefcick, Alison M. McCaig, Heather G. Jørgensen, Alison M. Michie   +8 more
wiley   +1 more source

RoundMi: A quantitative method to analyze mitochondrial morphology in mitotic cells

FEBS Open Bio, EarlyView.
RoundMi is a workflow for rapid analysis of mitochondrial morphology in mitotic cells. By combining adaptive preprocessing with automated segmentation and quantification, it enables accurate measurements from single focal plane images, reducing acquisition time and computational demands while remaining compatible with high‐throughput fixed and live ...
Elmira Parvindokht Bararpour, Christine Volmert, Valentina Piano   +2 more
wiley   +1 more source

Department of Health and Human Services implementation guidance for syringe services programs July 2010 [PDF]

The purpose of this document is to provide implementation guidance for the Department of Health and Human Services (HHS) programs interested in implementing syringe services programs (SSPs) for injection drug users (IDUs) with Fiscal Year (FY) 2010 ...

core  

Guiding AlphaFold to predict how Munc13‐1 opens Syntaxin‐1

FEBS Open Bio, EarlyView.
The syntaxin‐1 Habc‐domain (orange), linker (pink) and SNARE motif (yellow) form a closed conformation that binds to Munc18‐1 (violet) and is opened by the Munc13‐1 MUN domain (cyan) to form the SNARE complex that triggers neurotransmitter release.
Madhurima Chattopadhyay, Junjie Xu, Josep Rizo   +2 more
wiley   +1 more source

Asylum Seekers And Refugees Policy Guidance On Access To Health And Social Services (PDF 136 KB)

, 2004
This policy guidance is intended for staff working within the Health and Personal Social Services sector in Northern Ireland, and aims to provide advice and information on the provision of health and social care services to asylum seekers and refugees ...
Department of Health, Social Services and Public Safety   +1 more
core   +1 more source

A compendium of selected databases maintained by the State of Connecticut, Department of Public Health. December 2003.

, 2003
Electronic data; Title from PDF cover (viewed Dec. 21, 2005).; Prepared by the Bureaus of Community Health (BCH), Public Health Science (BPHS), and Regulatory Services (BRS).; "December 2003."; Harvested from the web on 12/22 ...
Connecticut. Dept. of Public Health.
core   +1 more source