Durable B‐Cell Impairment While Sparing IgA B Cells After Ocrelizumab Therapy in Multiple Sclerosis
ABSTRACT Objectives Ocrelizumab (OCR), a humanized anti‐CD20 monoclonal antibody, is highly efficient in relapsing–remitting multiple sclerosis (RR‐MS). We assessed early cellular B‐cell profiles in patients prior to OCR treatment, on OCR treatment, and after 15 months of therapy discontinuation.
Alexandra Garcia+20 more
wiley +1 more source
Digital Activity Markers in Chronic Inflammatory Demyelinating Polyneuropathy
ABSTRACT Objective To evaluate the utility of smartwatch and smartphone‐based activity metrics for assessing disease severity and quality of life in patients with chronic inflammatory demyelinating polyneuropathy (CIDP). Methods In the electronic monitoring of disease activity in patients with CIDP (EMDA‐CIDP) trial, we performed a prospective ...
Lars Masanneck+15 more
wiley +1 more source
Operacionalizando as categorias acesso e descentralização na análise de sistemas de saúde
O artigo apresenta proposta de operacionalização das categorias acesso e descentralização em modelo de análise de sistemas de saúde. Admite a hipótese de que se o sistema de saúde é descentralizado, ele vai permitir maior acesso dos usuários ao sistema ...
Virginia Alonso Hortale+2 more
doaj
Analyzing Disparity in Geographical Accessibility to Home Medical Care Using a Claims Database and Geographical Information System: Simulation Study. [PDF]
Morii Y+7 more
europepmc +1 more source
Circulating Interleukin‐6 Levels and Timing of Acute Ischemic Stroke Onset
ABSTRACT Intravenous thrombolysis is the most widely available effective ischemic stroke treatment, but is approved only if given within 4.5 h from stroke onset. Many patients are not treated because stroke onset time is unknown. We evaluated the cytokine interleukin 6 (IL‐6) in circulating blood after acute ischemic stroke (AIS).
Robert G. Kowalski+15 more
wiley +1 more source
Professional and service-user perspectives regarding the future of mental healthcare in Israel. [PDF]
Kramer A+4 more
europepmc +1 more source
Exploring the accessibility of health care service to Rohingya refugees in Malaysia
Suseela Devi Chandran+2 more
openalex +2 more sources
Accessibility of End-Stage Renal Disease Patients to Health Care Services of a Specialized Hospital
Md. Abdul Jabbar+4 more
openalex +2 more sources
The Road Not Taken: Misclassifying an Anti‐Seizure Medication as a Failure
ABSTRACT Objective To quantify how often anti‐seizure medications (ASMs) appear ineffective yet provide benefit when considering seizure frequency (SF) variability. Methods We used the CHOCOLATES seizure diary simulator to generate 100,000 patient seizure diaries that reflect natural SF variation in a heterogeneous population.
Christopher N. Henry+1 more
wiley +1 more source