Results 61 to 70 of about 3,605,266 (385)

Cell wall target fragment discovery using a low‐cost, minimal fragment library

FEBS Letters, EarlyView.
LoCoFrag100 is a fragment library made up of 100 different compounds. Similarity between the fragments is minimized and 10 different fragments are mixed into a single cocktail, which is soaked to protein crystals. These crystals are analysed by X‐ray crystallography, revealing the binding modes of the bound fragment ligands.
Kaizhou Yan, Mathew Stanley, Olawale Raimi, Andrew T. Ferenbach, Helge C Dorfmueller, Daan M. F. van Aalten   +5 more
wiley   +1 more source

Is incentive spirometry beneficial for patients with lung cancer receiving video-assisted thoracic surgery?

BMC Pulmonary Medicine, 2019
Background The effectiveness of Incentive spirometry (IS) in patients undergoing video-assisted thoracic surgery (VATS) remains lacking. We conducted a population-based study to investigate the effectiveness of IS on patients with lung cancers following ...
Chin-Jung Liu, Wen-Chen Tsai, Chia-Chen Chu, Chih-Hsin Muo, Wei-Sheng Chung   +4 more
doaj   +1 more source

Health Care for Veterans: Answers to Frequently Asked Questions [PDF]

, 2015
The Veterans Health Administration (VHA), within the Department of Veterans Affairs (VA), operates the nation’s largest integrated direct health care delivery system, provides care to approximately 6.6 million unique veteran patients, and employs more ...
Panangala, Sidath Viranga
core   +4 more sources

A qualitative study of patients’ feedback about Outpatient Parenteral Antimicrobial Therapy (OPAT) services in Northern England : implications for service improvement [PDF]

, 2018
Objective Outpatient parenteral antimicrobial therapy (OPAT) provides opportunities for improved cost savings, but in the UK, implementation is patchy and a variety of service models are in use.
Czoski Murray, Carolyn J., Mason, Samantha J., Meads, David, Minton, Jane, Mitchell, Elizabeth D., Twiddy, Maureen, Wright, Judy M.   +6 more
core   +2 more sources

Inhibiting stearoyl‐CoA desaturase suppresses bone metastatic prostate cancer by modulating cellular stress, mTOR signaling, and DNA damage response

FEBS Letters, EarlyView.
Bone metastasis in prostate cancer (PCa) patients is a clinical hurdle due to the poor understanding of the supportive bone microenvironment. Here, we identify stearoyl‐CoA desaturase (SCD) as a tumor‐promoting enzyme and potential therapeutic target in bone metastatic PCa.
Alexis Wilson, Mackenzie K Herroon, Shane Mecca, Laimar C Garmo, Jacob Lindquist, Shrila Rajendran, Steve M. Patrick, Izabela Podgorski   +7 more
wiley   +1 more source

Implementation of tobacco control measures in the Gulf Cooperation Council countries, 2008–2020

Substance Abuse Treatment, Prevention, and Policy, 2021
Background The World Health Organization (WHO) Framework Convention on Tobacco Control (FCTC) was developed to assist nations in reducing the demand and supply of tobacco.
Sarah S. Monshi, Jennifer Ibrahim
doaj   +1 more source

Employees’ perception of management skills in the Los Olivos Municipal Hospital

Revista de la Facultad de Medicina Humana, 2021
Objective: Analyze management skills from employees’ perception in the Los Olivos Municipal Hospital in 2019. Methods: Quantitative, correlational, cross-sectional study. A simple random sample of 52 participants was applied.
Irma Emperatriz Arrascue Lino, Luis Enrique Podestá Gavilano, Juan Pedro Matzumura Kazano, Hugo Florencio Gutiérrez Crespo, Raúl Alberto Ruiz Arias   +4 more
doaj   +1 more source

The neural crest‐associated gene ERRFI1 is involved in melanoma progression and resistance toward targeted therapy

Molecular Oncology, EarlyView.
ERRFI1, a neural crest (NC)‐associated gene, was upregulated in melanoma and negatively correlated with the expression of melanocytic differentiation markers and the susceptibility of melanoma cells toward BRAF inhibitors (BRAFi). Knocking down ERRFI1 significantly increased the sensitivity of melanoma cells to BRAFi.
Nina Wang, Qian Sun, Daniel Novak, Lei Zhu, Juliane Poelchen, Tamara Steinfass, Yiman Wang, Viktor Umansky, Jochen Utikal   +8 more
wiley   +1 more source

Dual targeting of RET and SRC synergizes in RET fusion‐positive cancer cells

Molecular Oncology, EarlyView.
Despite the strong activity of selective RET tyrosine kinase inhibitors (TKIs), resistance of RET fusion‐positive (RET+) lung cancer and thyroid cancer frequently occurs and is mainly driven by RET‐independent bypass mechanisms. Son et al. show that SRC TKIs significantly inhibit PAK and AKT survival signaling and enhance the efficacy of RET TKIs in ...
Juhyeon Son, Lily L. Remsing Rix, Bin Fang, Eric A. Welsh, Nicole V. Bremer, Valentina Foglizzo, Paola Roa, Nickole Sigcha‐Coello, Yi Liao, Eric B. Haura, Alexander Drilon, John M. Koomen, Emiliano Cocco, Uwe Rix   +13 more
wiley   +1 more source

Collegiate management in inpatient pediatric unit from health professionals’ perspective

O Mundo da Saúde, 2019
The hospitals make up the tertiary level of Health Care Network, which include sets of procedures in the context of the Health System, it involves high technology and high cost and integrates other health care levels.
Maria José Menezes Brito, Lívia Cozer Montenegro, Tereza Cristina Peixoto, Carolina da Silva Caram, Lilian Cristina Rezende   +4 more
doaj