Results 51 to 60 of about 16,870,425 (305)

The mental health care model in Brazil: analyses of the funding, governance processes, and mechanisms of assessment

Revista de Saúde Pública
OBJECTIVE This study aims to analyze the current status of the mental health care model of the Brazilian Unified Health System, according to its funding, governance processes, and mechanisms of assessment.
Thiago Lavras Trapé, Rosana Onocko Campos   +1 more
doaj   +1 more source

Operationalization of the Ghanaian Patients’ Charter in a Peri-urban Public Hospital: Voices of Healthcare Workers and Patients [PDF]

International Journal of Health Policy and Management, 2016
Background Health is a basic human right necessary for the exercise of other human rights. Every human being is, therefore, entitled to the highest possible standard of health necessary to living a life of dignity. Establishment of patients’ Charter is
Lily Yarney, Thomas Buabeng, Diana Baidoo, Justice Nyigmah Bawole   +3 more
doaj   +1 more source

Developmental programmes drive cellular plasticity, disease progression and therapy resistance in lung adenocarcinoma

Molecular Oncology, EarlyView.
This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska, Stephany Gallardo, Nur S. Zainal, Leena Arora, Matthew Ellis, Maria‐Antoinette Lopez, Judith Austine, Sai Pittla, Serena J Chee, Aiman Alzetani, Emily C Shaw, Christian H Ottensmeier, Gareth J Thomas, Christopher J Hanley   +13 more
wiley   +1 more source

International Hospital Performance Assessment: Developing a Questionnaire

Novelty in Biomedicine, 2018
Background: As there is no valid questionnaire for assessing international hospital performance from providers’ perspective, this study aimed to develop a reliable as well as valid questionnaire for Iranian hospitals.Materials and Methods: To develop the
Mona Mohammadnia, Kamran Hajinabi, Mahmoud Mahmoudi Majd Abadi Farahani, Ali Komeli   +3 more
doaj   +1 more source

Area resource file (ARF): national county-level health resource information database, 2004 ed.

, 2022
A database containing more than 6,000 variables for U.S. counties. ARF contains information on health facilities, health professions, measures of resource scarcity, health status, economic activity, health training programs, and socioeconomic and ...
Bureau of Health Professions, Quality Resource Systems, Inc, National Center for Health Workforce Analysis, Health Resources and Services Administration, U. S. Department of Health and Human Services   +4 more
core   +1 more source

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

Molecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq, Marc Terrones, Felicia Rodrigues Fortes, Anne Schepers, Alessia Denis, Christophe Deben, Ken Op de Beeck, Guy Van Camp, Geert Vandeweyer   +8 more
wiley   +1 more source

International Hospitals’ Performance Variables: A Comparative Study

Novelty in Biomedicine, 2019
Background: To define a series of variable that separates international hospitals from other ones is the main aim of this study. Materials and Methods: After choosing some countries in the worldwide, two hospitals, which were the leaders on international
Mona Mohammadnia, Kamran Hajinabi, Mahmoud Mahmoudi Majdabadi Farahani, Ali Komeili   +3 more
doaj   +1 more source

Targeting transcription factors associated with hemoglobinopathies: Lessons from successful interventions and implications for cancer

Molecular Oncology, EarlyView.
This review summarizes the transcription factors, repressive chromatin‐modifying complexes, and epigenetic mechanisms that control fetal hemoglobin repression. Notably, many regulators of γ‐globin silencing also function in transcriptional and epigenetic networks that drive cancer, highlighting opportunities to translate advances in hemoglobinopathy ...
Meigen Yu, Puspa Das, Xing Zhang, Xiaodong Cheng   +3 more
wiley   +1 more source

Pharmacological chromatin remodeling enhances response to estrogen therapy in ER+ breast cancer

Molecular Oncology, EarlyView.
Estrogen therapy elicits clinical benefit in ~ 30% of patients with endocrine‐resistant estrogen receptor (ER)‐positive breast cancer. Based on findings that ER transcriptional activation underlies response to estrogen therapy, we tested the effects of epigenetic dysregulation via pharmacological inhibition of histone deacetylases (HDACi).
Anneka L. Johnson Thomas, Barbara Karakyriakou, Patricia C. Muskus, Alyssa M. Roberts, Justin Rendleman, Alexa Warren, Hanxu Lu, Kimberly A. Birmingham, Malone K. Friedman, Abigail E. Goen, Huijuan Yang, Owen M. Wilkins, Fred W. Kolling, Eugene Demidenko, Julie M. Jorns, Brock C. Christensen, Todd W. Miller   +16 more
wiley   +1 more source

Collegiate management in inpatient pediatric unit from health professionals’ perspective

O Mundo da Saúde, 2019
The hospitals make up the tertiary level of Health Care Network, which include sets of procedures in the context of the Health System, it involves high technology and high cost and integrates other health care levels.
Maria José Menezes Brito, Lívia Cozer Montenegro, Tereza Cristina Peixoto, Carolina da Silva Caram, Lilian Cristina Rezende   +4 more
doaj