Results 81 to 90 of about 3,605,266 (385)
Molecular Oncology, EarlyView.Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon +13 more
wiley +1 more source
Fragmentation in Mental Health Benefits and Services: A Preliminary Examination into Consumption and Outcomes [PDF]
, 2010 In this chapter, we examine consumption patterns and health outcomes within a health insurance system in which mental health benefits are administered under a carved-out insurance plan.
Grossman, Daniel +2 more
core +1 more source
Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin
Molecular Oncology, EarlyView.The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla +10 more
wiley +1 more source
Perceptions and trends in the use of community pharmacies in Ghana
Journal of Pharmaceutical Policy and Practice, 2019 Objective To examine the patterns in utilization of community pharmacies and perceptions of the general public towards community pharmacists’ role in health services delivery. Method A cross-sectional household survey was conducted in Ga West district. A
Grace Adjei Okai +2 more
doaj +1 more source
Putting Families First: How the Opioid Epidemic is Affecting Children and Families, and the Child Welfare Policy Options to Address It [PDF]
, 2019 : Opioids and Child Welfare Across the country, placements in foster care are rising. In 2016, the U.S. Department of Health and Human Services reported that 273,539 children in the U.S. entered foster care.
American Academy of Pediatrics Council on Foster Care, Adoption, and Kinship Care +3 more
core +1 more source
Molecular Oncology, EarlyView.We show that the majority of the 18 analyzed recurrent cancer‐associated ERBB4 mutations are transforming. The most potent mutations are activating, co‐operate with other ERBB receptors, and are sensitive to pan‐ERBB inhibitors. Activating ERBB4 mutations also promote therapy resistance in EGFR‐mutant lung cancer.
Veera K. Ojala +15 more
wiley +1 more source
Scientifica, 2016 We examined parent-reported adverse childhood experiences (ACEs) and associated outcomes among American Indian and Alaska Native (AI/AN) children aged 0–17 years from the 2011-2012 National Survey of Children’s Health.
Mary Kay Kenney, Gopal K. Singh
doaj +1 more source
Parents and Children Together: Design and Implementation of Two Healthy Marriage Programs [PDF]
, 2016 The Parents and Children Together (PACT) evaluation, conducted by Mathematica Policy Research for the Office of Research, Planning, and Evaluation, Administration for Children and Families (ACF), U.S. Department of Health and Human Services, is examining
Heather Zaveri, Scott Baumgartner
core
Interdisciplinary Dissertation Research Among Public Health Doctoral Trainees, 2003-2015 [PDF]
, 2018 Given the call for more interdisciplinary research in public health, the objectives of this study were to (1) examine the correlates of interdisciplinary dissertation completion and (2) identify secondary fields most common among interdisciplinary public
Brown-Podgorski, Brittany L. +4 more
core +1 more source
Peroxidasin enables melanoma immune escape by inhibiting natural killer cell cytotoxicity
Molecular Oncology, EarlyView.Peroxidasin (PXDN) is secreted by melanoma cells and binds the NK cell receptor NKG2D, thereby suppressing NK cell activation and cytotoxicity. PXDN depletion restores NKG2D signaling and enables effective NK cell–mediated melanoma killing. These findings identify PXDN as a previously unrecognized immune evasion factor and a potential target to improve
Hsu‐Min Sung +17 more
wiley +1 more source