Results 91 to 100 of about 2,829,962 (313)

Research-Practice-Policy Partnerships for Implementation of Evidence-Based Practices in Child Welfare and Child Mental Health [PDF]

, 2015
Partnerships between researchers, practitioners, and policymakers represent a promising avenue for improving outcomes for young people and families.In a new report, Lawrence Palinkas, Cherry Short, and Marleen Wong of the University of Southern ...
Cherry Short, Lawrence A. Palinkas, Marleen Wong   +2 more
core  

User perceptions and utilisation of features of an AI-enabled workplace digital mental wellness platform ‘mindline at work’

BMJ Health & Care Informatics
Background The working population encounters unique work-related stressors. Despite these challenges, accessibility to mental healthcare remains limited.
Xinyi Casuarine Low, Sungwon Yoon, Creighton Heaukulani, Hendra Goh, Janice Huiqin Weng   +4 more
doaj   +1 more source

Colorectal cancer‐derived FGF19 is a metabolically active serum biomarker that exerts enteroendocrine effects on mouse liver

Molecular Oncology, EarlyView.
Meta‐transcriptome analysis identified FGF19 as a peptide enteroendocrine hormone associated with colorectal cancer prognosis. In vivo xenograft models showed release of FGF19 into the blood at levels that correlated with tumor volumes. Tumoral‐FGF19 altered murine liver metabolism through FGFR4, thereby reducing bile acid synthesis and increasing ...
Jordan M. Beardsley, Michael W. Rohr, Joseph A. Goode, Sai Preethi Nakkina, Jignesh G. Parikh, Deborah A. Altomare   +5 more
wiley   +1 more source

Effective strategies for scaling up evidence-based practices in primary care: a systematic review

Implementation Science, 2017
Background While an extensive array of existing evidence-based practices (EBPs) have the potential to improve patient outcomes, little is known about how to implement EBPs on a larger scale.
Ali Ben Charif, Hervé Tchala Vignon Zomahoun, Annie LeBlanc, Léa Langlois, Luke Wolfenden, Sze Lin Yoong, Christopher M. Williams, Roxanne Lépine, France Légaré   +8 more
doaj   +1 more source

Identification of serum protein biomarkers for pre‐cancerous lesions associated with pancreatic ductal adenocarcinoma

Molecular Oncology, EarlyView.
This work identified serum proteins associated with pancreatic epithelial neoplasms (PanINs) and early‐stage PDAC. Proteomics screens assessed genetically engineered mice with abundant PanINs, KPC mice (Lox‐STOP‐Lox‐KrasG12D/+ Lox‐STOP‐Lox‐Trp53R172H/+ Pdx1‐Cre) before PDAC development and also early‐stage PDAC patients (n = 31), compared to benign ...
Hannah Mearns, Jaclyn S. Long, Sergio Lilla, Kelly Hodge, Marcus J. G. W. Ladds, Colin Nixon, Paula Fernández‐Palanca, Sara Zanivan, Pilar Acedo, Stephen P. Pereira, Kevin M. Ryan   +10 more
wiley   +1 more source

Targeted modulation of IGFL2‐AS1 reveals its translational potential in cervical adenocarcinoma

Molecular Oncology, EarlyView.
Cervical adenocarcinoma patients face worse outcomes than squamous cell carcinoma counterparts despite similar treatment. The identification of IGFL2‐AS1's differential expression provides a molecular basis for distinguishing these histotypes, paving the way for personalized therapies and improved survival in vulnerable populations globally.
Ricardo Cesar Cintra, Lucca Paolo Hsu Helmich, Daniel Rodrigues de Bastos, Laura Sichero, Patrícia Savio de Araujo‐Souza, Fabio Passetti, Luisa Lina Villa   +6 more
wiley   +1 more source

Self-Assessed Health Status and Satisfaction with Health Care Services in the Context of the Enlarged European Union [PDF]

The paper aims at analysing the relationship between self-rated health-status, satisfaction with health care services and socio-economic factors, in the context of different national health care systems in the enlarged European Union.
Popescu, Livia, Rat, Cristina, Rebeleanu-Bereczki, Adina   +2 more
core  

Pre‐analytical optimization of cell‐free DNA and extracellular vesicle‐derived DNA for mutation detection in liquid biopsies

Molecular Oncology, EarlyView.
Pre‐analytical handling critically determines liquid biopsy performance. This study defines practical best‐practice conditions for cell‐free DNA (cfDNA) and extracellular vesicle–derived DNA (evDNA), showing how processing time, storage conditions, tube type, and plasma input volume affect DNA integrity and mutation detection.
Jonas Dohmen, Lucrezia De Santis, Bret M. Stephens, Vincent Bernard, Jörg C. Kalff, Lara Braun, Phillipp Leyendecker, Johannes Röttgen, Daniel Weissinger, Anirban Maitra, Paola A. Guerrero, Alexander Semaan   +11 more
wiley   +1 more source

Empowering women : the effect of women's decision-making power on reproductive health services uptake -- evidence from Pakistan [PDF]

A large body of research has attempted to explore the links between women's autonomy and their uptake of reproductive health services in the South Asia region, but the evidence so far is inconclusive.
Hou, Xiaohui, Ma, Ning
core  

European health systems are changing in response to the financial crisis but face barriers to implementing necessary reforms [PDF]

, 2013
The financial crisis has affected almost every aspect of European governments’ ability to maintain public services, and healthcare has been no exception.
Mladovsky, Philipa, Thomson, Sarah
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