Results 121 to 130 of about 2,534,664 (269)

PARP inhibitors induce a senescence phenotype in non‐small cell lung carcinoma cell lines

FEBS Open Bio, EarlyView.
Talazoparib is the most potent inducer of senescence among different PARP1 inhibitors in human NSCLC cells. In the absence of PARP, no senescence phenotype was observed, demonstrating that PARP1 is necessary for the induction of senescence by this inhibitor.
Camille Huart, Manon Van den Abbeel, Christoph Schifflers, Karim Bouhjar, Andrea Scarmelotto, Alexis Khelfi, Anne‐Catherine Wera, Carine Michiels   +7 more
wiley   +1 more source

Health care workers’ experiences of calling-for-help when taking care of critically ill patients in hospitals in Tanzania and Kenya

BMC Health Services Research
Background When caring for critically ill patients, health workers often need to ‘call-for-help’ to get assistance from colleagues in the hospital. Systems are required to facilitate calling-for-help and enable the timely provision of care for critically
Elibariki Godfrey Mkumbo, Tamara Mulenga Willows, Onesmus Odongo Onyango, Karima Khalid, John Maiba, Carl Otto Schell, Jacquie Oliwa, Jacob McKnight, Tim Baker   +8 more
doaj   +1 more source

Moving people to deliver services : how can the WTO help? [PDF]

The previous General Agreement on Trade in Services (GATS) negotiations produced little liberalization of the movement of individual service providers (mode 4), and the potentially large global gains from suchmovement remain unrealized.
Chaudhuri, Sumanta, Mattoo, Aaditya, Self, Richard   +2 more
core  

Comprehensive Evaluation of Home Visiting New Hampshire: Final Report. [PDF]

, 2005
Home Visiting New Hampshire (HVNH) is a statewide initiative of the Division of Public Health Services (DPHS) Bureau of Maternal and Child Health. The program began in 2001 with awards to support programs in 13 sites and expanded in 2002 for a total of ...
Streitburger, Kim, Wauchope, Barbara
core   +1 more source

Applicability of mitotic figure counting by deep learning: a development and pan‐cancer validation study

FEBS Open Bio, EarlyView.
In this study, we developed a deep learning method for mitotic figure counting in H&E‐stained whole‐slide images and evaluated its prognostic impact in 13 external validation cohorts from seven different cancer types. Patients with more mitotic figures per mm2 had significantly worse patient outcome in all the studied cancer types except colorectal ...
Joakim Kalsnes, Maria X. Isaksen, Frida Julbø, Manohar Pradhan, Andreas Kleppe, Sepp De Raedt, Ole‐Johan Skrede, Turid Torheim, John Arne Nesheim, Hans Martin Mohn, Hanne A. Askautrud, Karolina Cyll, Wanja Kildal, Emma Rewcastle, Melinda Lillesand, Vebjørn Kvikstad, Emiel Janssen, Robert Jones, Odd Terje Brustugun, Bjørn Brennhovd, Erik Skaaheim Haug, Lill‐Tove Rasmussen Busund, Elin Richardsen, Sigve Andersen, Tom Dønnem, Kristina Lindemann, Gunnar Kristensen, Neil A. Shepherd, Marco Novelli, Knut Liestøl, David Kerr, Håvard E. Danielsen, Tarjei S. Hveem   +32 more
wiley   +1 more source

The political economy of health services provision and access in Brazil [PDF]

The authors examine the impact of local politics and government structure on the allocation of publicly subsidized (SUS) health services across municipios (counties) in Brazil, and on the probability that uninsured individuals who require medical ...
Cropper, Maureen, Mushfiq Mobarak, Ahmed, Rajkumar, Andrew Sunil   +2 more
core  

Whose outcomes are they anyway? Report of the pilot evaluation of a joint service\ud [PDF]

, 2011
Health and social care partnership working is often predicated on the notion that it improves outcomes for service users. Yet there is a lack of evidence linking partnerships to changes in outcomes. Against this background, the Health Services Management
Dickinson, Helen, Glasby, Jon, McCarthy,, Linda, Miller, Robin   +3 more
core  

Establishing an assay to evaluate d‐amino acid oxidase enzyme kinetics and inhibition using WST‐8 redox dye

FEBS Open Bio, EarlyView.
This study investigated a novel WST‐8‐based assay for evaluating d‐Amino acid oxidase (DAO) inhibitors. We confirmed its effectiveness using known inhibitors and found that uremic toxins possess relatively weak inhibitory activity compared to existing drugs.
Kahoko Miyake, Yuki Enoki, Yuka Nakazawa, Kazuaki Taguchi, Kazuaki Matsumoto   +4 more
wiley   +1 more source

MiR‐513a promotes human erythroid differentiation by modulating c‐Jun

FEBS Open Bio, EarlyView.
During early human erythropoiesis, miR‐513a promoted erythroid differentiation in primary human CD34+ hematopoietic stem‐progenitor cells and human TF‐1 erythroleukemic cells by indirectly decreasing c‐Jun and phospho‐c‐Jun expression, which are associated with increased GATA1 expression.
MinJung Kim, Brittany Taylor, Shannon Bolten, Christian L. Eberly, Mahliya Abdurahman, T. Michael Creed, Acong Yang, Taylor L. Hatchet, Tristan Dyson, Shuo Gu, Curt I. Civin, Tami J. Kingsbury   +11 more
wiley   +1 more source

A new approach to social assistance : Latin America's experience with conditional cash transfer programs [PDF]

Conditional cash transfers are a departure from more traditional approaches to social assistance, that represents an innovative, and increasingly popular channel for the delivery of social services.
Rawlings, Laura B.
core