Results 111 to 120 of about 8,343,686 (298)
Health-related quality of life and well-being health state values among Dutch oldest old
Patient Preference and Adherence, 2019 Riaan Botes,1 Karin M Vermeulen,1 Anthonie M Gerber,2 Adelita V Ranchor,3 Erik Buskens11Department of Epidemiology, University Medical Center Groningen, University of Groningen, Groningen, 9700 RB, The Netherlands; 2Department of Basic Medical Sciences ...
Botes R +4 more
doaj
New Hampshire civic health index [PDF]
, 2009 The Carsey Institute is participating in a study to examine America\u27s civic health. Led by the Conference on Citizenship (NCoC), America\u27s Civic Health Index is an annual study that measures a wide variety of civic indicators, such as community ...
Dillon, Michele, Rogers, Shannon H.
core +1 more source
Tau acetylation at K331 has limited impact on tau pathology in vivo
FEBS Letters, EarlyView.We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto +3 more
wiley +1 more source
Colorado Health Gaps Report: What's Driving Health Differences Across the State and How Can Those Gaps Be Closed? [PDF]
, 2015 Why is there so much difference in the health of residents in one county compared to other counties in the same state? In this report, the County Health Rankings & Roadmaps program explores how wide gaps are throughout Colorado and what is driving those ...
Bridget Catlin +2 more
core
Calpain small subunit homodimerization is robust and calcium‐independent
FEBS Letters, EarlyView.Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy +4 more
wiley +1 more source
Structural insights into an engineered feruloyl esterase with improved MHET degrading properties
FEBS Letters, EarlyView.A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa +5 more
wiley +1 more source
Mental Health And The Role Of The States [PDF]
, 2015 Researchers from the State Health Care Spending Project -- a collaboration between The Pew Charitable Trusts and the John D. and Catherine T. MacArthur Foundation -- sought to better understand the country's mental health challenges and, in particular ...
Meredith Klein +3 more
core
Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system
FEBS Letters, EarlyView.Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley +1 more source
Patient Preference and Adherence, 2008 Hwee-Lin, Wee1, Shu-Chuen Li2, Xu-Hao Zhang1, Feng Xie3, David Feeny4, Nan Luo5, Yin-Bun Cheung6, David Machin7, Kok-Yong Fong8, Julian Thumboo81Department of Pharmacy, National University of Singapore (NUS), Singapore; 2Discipline of Pharmacy and ...
Hwee-Lin +6 more
doaj
ChemElectroChemLithium‐ion batteries (LIBs) are widely used for energy storage in various industries due to their high energy density and long lifespan. However, degradation mechanisms may lead to hazardous conditions, such as thermal runaway.
Eric L. Pereira +2 more
doaj +1 more source