Results 231 to 240 of about 8,269,895 (309)

Stimulator of interferon genes agonist augmented antitumor immunity of osimertinib in Egfr‐mutated lung cancer

Molecular Oncology, EarlyView.
Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura, Tadahiro Kuribayashi, Johannes Brägelmann, Sachi Okawa, Masataka Taoka, Shunta Mori, Tomoka Nishimura, Takaaki Tanaka, Go Makimoto, Kiichiro Ninomiya, Kammei Rai, Eiki Ichihara, Ryohei Katayama, Katsuyuki Hotta, Masahiro Tabata, Yosuke Togashi, Yoshinobu Maeda, Martin L. Sos, Katsuyuki Kiura, Kadoaki Ohashi   +19 more
wiley   +1 more source

The Relationship Between Dental Caries and the Health Status of Anganwadi Children Aged 3-6 Years.

J Pharm Bioallied Sci
Bharti R, Ranadheer E, Bhattacharya D, Nawaid KA, Kumari S, Bharti S.   +5 more
europepmc   +1 more source

Oral health status and its relation to frailty in older adults: a cross-sectional study. [PDF]

BMC Geriatr
Widita E, Rodestawati B, Hanindriyo L, Vega CAW, Nur'aini B, Jang JH, Takehara S.   +6 more
europepmc   +1 more source

Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining

Molecular Oncology, EarlyView.
IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis, Jack V. Mills, Wojciech Niedzwiedz, Valentine M. Macaulay   +3 more
wiley   +1 more source

Clinical factors associated with severely reduced health status in patients with COPD and comorbid depression/anxiety: The Swedish PRAXIS study. [PDF]

NPJ Prim Care Respir Med
Öfverholm T, Hasselgren M, Lisspers K, Nager A, Eliason G, Giezeman M, Janson C, Kisiel MA, Montgomery S, Ställberg B, Sundh J, Sandelowsky H.   +11 more
europepmc   +1 more source

USP29‐regulated noncanonical stabilization of the hypoxia‐inducible factor‐α in aggressive prostate cancer

Molecular Oncology, EarlyView.
We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober, Leire Moreno‐Cugnon, Laura Martínez‐Pérez, Amaia Ercilla, Amaia Zabala‐Letona, Adrián Vicente‐Barrueco, Maider Fagoaga‐Eugui, Saioa Garcia‐Longarte, Blanca Calle‐Ciborro, Encarnación Pérez‐Andrés, Onintza Carlevaris, Sara Pozo, Isabel Mendizabal, Ugo Mayor, Arkaitz Carracedo, Violaine Sée, Edurne Berra   +16 more
wiley   +1 more source

Mavacamten in Chinese Patients with Obstructive Hypertrophic Cardiomyopathy: Patient-Reported Health Status Analysis up to 78 Weeks in the EXPLORER-CN Study. [PDF]

Cardiol Ther
Tian Z, Li X, Li L, Zhang Q, Wang J, Shi Y, Peng D, Ma W, Yang P, Cheng X, Jin W, Wang F, Memaj A, Xie Y, Pan B, Florea V, Zheng J, Zhong Y, Zhang S.   +18 more
europepmc   +1 more source

Demographics, Habits, Diseases & Current Health Status of Varendra University Students in Bangladesh

Khanam K, kona N, Lima AS, Lopa SS, Akhter S, Rahman M.   +5 more
europepmc   +1 more source

Comparative oral health status of two pre-Hispanic archaeological sites in Costa Rica. [PDF]

Front Oral Health
Baldi NF, Fernández-Chaves JM, Ruiz-Imbert AC, Infante-Herrera D, Ibarra-Valverde K, Ramírez K.   +5 more
europepmc   +1 more source