Results 281 to 290 of about 625,873 (344)

Single‐Cell Dissection Reveals Immune Dysregulation After CD5 or CD7‐Directed Chimeric Antigen Receptor T‐Cell Therapy

Advanced Science, EarlyView.
Single‐cell RNA/TCR/BCR sequencing reveals that 5CAR therapy in T‐ALL induces T‐cell exhaustion, reduces EBV‐associated TCRs, lowers TCR/BCR diversity, and increases NK/DC/monocyte activation and function. In contrast, 7CAR therapy reduces multiple pathogen‐associated TCRs, enhances NK cell activation and function, decreases monocyte activation, and ...
Yuechen Luo, Haixiao Zhang, Kaiting Tang, Yiming Wang, Huajiang Dong, Wei Qi, Lingling Shan, Yue Tan, Liping Zhao, Jun Shi, Erlie Jiang, Jing Pan, Xiaoming Feng   +12 more
wiley   +1 more source

Emergency Department utilization in Switzerland: Comparing Swiss natives with first- and second-generation immigrants. [PDF]

J Migr Health
Alesci L, Francetic I.
europepmc   +1 more source

Enzymatic Remodelling of Tumour Microenvironment Enhances Anti‐CEACAM5 CAR T‐Cell Efficacy Against Colorectal Cancer

Advanced Science, EarlyView.
This study shows anti‐CEACAM5 CAR T‐cells are ineffective against colorectal cancer (CRC) because of CEACAM5 sequestration at intercellular junctions and the thick tumour cell glycocalyx. Enzymatic treatments of CRC cell monolayer/tissue section with trypsin or hyaluronidase restore CEACAM5 availability, enhance CAR T‐cell activation, increase ...
Debasis Banik, Christopher J. Ward, Soura Chakraborty, Ziwei Zhang, Daniel Heraghty, Prasanna Suresh, Bing Li, Shekhar Kedia, Jhuma Pramanik, Simon J. Davis, James P. Roy, Michael A. Chapman, Bidesh Mahata, David Klenerman   +13 more
wiley   +1 more source

Hidden crisis of undiagnosed hypertension among women of reproductive age with elevated blood pressure: a regional disparities and determinants using Tanzania nation survey. [PDF]

BMC Cardiovasc Disord
Bintabara D, Kamata CC, Sindato E, Konje E.   +3 more
europepmc   +1 more source

Immune Predictors of Radiotherapy Outcomes in Cervical Cancer

Advanced Science, EarlyView.
This study reveals dynamic immune remodeling in cervical cancer following radiotherapy. Single‐cell analysis identifies the C3/C3AR1 axis as a central mediator of epithelial–myeloid crosstalk, whose inhibition reduces treatment efficacy in mice. Guided by these insights, the eight‐feature machine‐learning model: Cervical Cancer Radiotherapy Immune ...
Linghao Wang, Jie Zhu, Zequn Ding, Zhiyuan Xie, Xingchen Liu, Feihong Zhang, Xiaojun Liu, Yan Zhang, Haiyan Chen   +8 more
wiley   +1 more source

Longitudinal trends in vaping, smoking, and harmful alcohol use across sexual orientations in the UK (2014-2021). [PDF]

PLoS One
Bai Y, Cao P, Kim C, Ienciu K, Ehi G, Chum A.   +5 more
europepmc   +1 more source

Geography Matters: Integrating Spatial Determinants to Tackle Public Health Disparities. [PDF]

Environ Health Insights
Ortiz-Prado E, Acosta-Muñoz MC, Cuenca-Calvopiña K, Cadena MP, Izquierdo-Condoy JS, Vasconez-Gonzalez J.   +5 more
europepmc   +1 more source

Using an AI-powered Mobile Application Chatbot to Address Maternal Depression Indicators and Inquiries in the Perinatal and Postpartum Periods: A Multimethod Analysis. [PDF]

Inquiry
Peters CJ, Aldana Lainez V, Clark K, Jasczynski M, Nguyen QC, Norell EM.   +5 more
europepmc   +1 more source