Results 61 to 70 of about 625,873 (344)

PARP inhibitors elicit distinct transcriptional programs in homologous recombination competent castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
PARP inhibitors are used to treat a small subset of prostate cancer patients. These studies reveal that PARP1 activity and expression are different between European American and African American prostate cancer tissue samples. Additionally, different PARP inhibitors cause unique and overlapping transcriptional changes, notably, p53 pathway upregulation.
Moriah L. Cunningham, Jasibel Vasquez‐Gonzalez, Samantha M. Barnada, Salome Tchotorlishvili, Latese Jones, Ryan Maguire, Genevieve Lewis, Kinza Rizwan, Jenny Deng, Salma Koachar, Drithi Patel, Hailey Shankle, Tessa Mulders, Namra Ajmal, Charalambos Solomides, Emad S. Alnemri, Teresa F. Alnemri, Ayesha A. Shafi, Leonard G. Gomella, Wm Kevin Kelly, Steven B. McMahon, Matthew J. Schiewer   +21 more
wiley   +1 more source

Advancing Intersectional Discrimination Measures for Health Disparities Research: Protocol for a Bilingual Mixed Methods Measurement Study

JMIR Research Protocols, 2021
BackgroundGuided by intersectionality frameworks, researchers have documented health disparities at the intersection of multiple axes of social status and position, particularly race and ethnicity, gender, and sexual orientation ...
Ayden I Scheim, Greta R Bauer, João L Bastos, Tonia Poteat   +3 more
doaj   +1 more source

Racial/ethnic disparities in health-related quality of life and health status across pre-, early-, and mid-adolescence: a prospective cohort study. [PDF]

, 2019
PURPOSE:To examine (1) racial/ethnic disparities in health-related quality of life (HRQOL) and overall health status among Black, Latino, and White youth during adolescence; (2) whether socioeconomic status (SES) and family contextual variables influence
Cuccaro, Paula M, Elliott, Marc N, Fradkin, Chris, Schuster, Mark A, Tortolero Emery, Susan, Wallander, Jan L   +5 more
core  

Psychosocial health disparities in early childhood: Socioeconomic status and parent migration background

SSM - Population Health, 2022
The association between low socioeconomic status (SES), migration background and psychosocial health could be various in different age stages, rare research has investigated associations in very early childhood. Cross-sectional data of SES, parental migration background, and child's psychosocial problems among 2149 children were collected (M age = 24.6 
Jie Luo, Amy van Grieken, Junwen Yang-Huang, Suzanne J. van den Toren, Hein Raat   +4 more
openaire   +3 more sources

Reduced vascular leakage correlates with breast carcinoma T regulatory cell infiltration but not with metastatic propensity

Molecular Oncology, EarlyView.
A mouse model for vascular normalization and a human breast cancer cohort were studied to understand the relationship between vascular leakage and tumor immune suppression. For this, endothelial and immune cell RNAseq, staining for vascular function, and immune cell profiling were employed.
Liqun He, Chiara Testini, Neda Hekmati, Altea Bonello, Aglaia Schiza, Emmanuel Nwadozi, Mia Phillipson, Carina Strell, Michael Welsh   +8 more
wiley   +1 more source

An overview of reviews on strategies to reduce health inequalities

International Journal for Equity in Health, 2020
Background Governments are incentivized to develop and implement health action programs focused on equity to ensure progress with effective strategies or interventions.
Nathaly Garzón-Orjuela, Daniel Felipe Samacá-Samacá, Silvia Catalina Luque Angulo, Carmen Verônica Mendes Abdala, Ludovic Reveiz, Javier Eslava-Schmalbach   +5 more
doaj   +1 more source

Regional and income disparities in treatment and drug adherence of patients with dyslipidemia: a retrospective cohort study in South Korea, 2003–2015

BMC Geriatrics, 2021
Backgrounds Health disparities represent a major public health problem that needs to be addressed, and a variety of factors, including geographical location and income, can contribute to these disparities.
Kyu-Tae Han, Dong-Woo Choi, Seungju Kim
doaj   +1 more source

Influence of Socioeconomic Factors, Gender and Indigenous Status on Smoking in Taiwan. [PDF]

, 2016
The indigenous Austronesian minority of Taiwan is heavily affected by health disparities which may include suffering from a greater burden of the tobacco epidemic.
Hwang, Chiou-Wei, Keller, Joseph Jordan, Lin, Ching-Feng, Lo, Feng-En, Lo, Wen-Min, Lyu, Shu-Yu, Morisky, Donald E, Tsai, Liang-Ting, Yang, Chih-Chien   +8 more
core   +3 more sources

Perspectives in educating molecular pathologists on liquid biopsy: Toward integrative, equitable, and decentralized precision oncology

Molecular Oncology, EarlyView.
Liquid biopsy enables minimally invasive, real‐time molecular profiling through analysis of circulating biomarkers in biological fluids. This Perspective highlights the importance of training pathologists through integrative educational programs, such as the European Masters in Molecular Pathology, to ensure effective and equitable implementation of ...
Marius Ilié, Umberto Malapelle, Catherine Alix‐Panabières, Claus Lindbjerg Andersen, Sandra Chlebowski, Vivien Lake, Caroline Lacoux, Virginie Lespinet‐Fabre, Olivier Bordone, Simon Heeke, Christophe Bontoux, Ellen Heitzer, Klaus Pantel, Paul Hofman   +13 more
wiley   +1 more source

Socio-demographic disparity in oral health among the poor: a cross sectional study of early adolescents in Kilwa district, Tanzania

BMC Oral Health, 2010
Background There is a lack of studies considering social disparity in oral health emanating from adolescents in low-income countries. This study aimed to assess socio-demographic disparities in clinical- and self reported oral health status and a number ...
Astrom Anne N, Mashoto Kijakazi O, Skeie Marit S, Masalu Joyce R   +3 more
doaj   +1 more source