Results 271 to 280 of about 582,509 (334)

Experimental research of impact on psychological state for adolescents with high-intensity interval training intervention. [PDF]

Front Psychol
Li YT, Zhou Y.
europepmc   +1 more source

The subcellular distribution of phosphorylated Y‐box‐binding protein‐1 at S102 in colorectal cancer patients, stratified by KRAS mutational status and clinicopathological features

Molecular Oncology, EarlyView.
This study identifies nuclear YB‐1 S102 phosphorylation as a marker associated with KRAS and FBXW7 mutations in colorectal cancer. Mutated KRAS correlates specifically with nuclear, not cytoplasmic, S102 YB‐1. These findings provide the first ex vivo evidence of this link in CRC and suggest future studies should assess the prognostic and therapeutic ...
Konstanze Lettau, Stephan Forchhammer, Birgit Fehrenbacher, Lejla Mahmutovic, Marcus Scharpf, Gunnar Blumenstock, Martin Schaller, Irina Bonzheim, Shayan Khozooei, Mahmoud Toulany   +9 more
wiley   +1 more source

Benthic macroinvertebrate diversity as biological indicators of health status of Kibumba urban wetland, Kigali City, Rwanda

Prince Mugisha Safari, Abel Tuyishimire, Alliane Iradukunda, Edmond Twagirayezu, Rashidi Mwimba, Methode Majyambere, Alphonse Nzarora, Aisha Nyirama, Jean de Dieu Uwizelimana   +8 more
openalex   +1 more source

Evolution and interaction mechanisms of China's high-performing national healthcare system. [PDF]

BMC Health Serv Res
Feng C, Chen F, Ye Z, Zhang F.
europepmc   +1 more source

Therapeutic applications of a novel humanized monoclonal antibody targeting chemokine receptor CCR9 in pancreatic cancer

Molecular Oncology, EarlyView.
C–C chemokine receptor type 9 (CCR9) is an immune checkpoint in pancreatic ductal adenocarcinoma (PDAC). Novel anti‐CCR9 antibody SRB2 was evaluated in combination with cytotoxic chemotherapy in PDAC cells, patient‐derived organoids, patient‐derived xenografts, and humanized mouse models.
Hannah G. McDonald, Anna M. Reagan, Charles J. Bailey, Mei Gao, Muqiang Gao, Angelica L. Solomon, Michael J. Cavnar, Prakash K. Pandalai, Mautin T. Barry‐Hundeyin, Megan M. Harper, Justin A. Rueckert, Ángela Turrero, Araceli Tobio, Anxo Vidal, Daniel Roca‐Lema, Elia Álvarez‐Coiradas, Pablo Garrido, Laureano Simón, Joseph Kim   +18 more
wiley   +1 more source

Health Indicators in the Eastern Mediterranean Regional Countries: Ranking and Evaluating the Status of Iran

Pardis Mohammadzadeh, Maryam Afraie, Elham Nouri, Mohammad Aziz Rasouli, Ghobad Moradi   +4 more
openalex   +1 more source

Developing socio-epidemiological indicators of sexual health among migrant population in Chile. [PDF]

Arch Public Health
Adrian Parra C, Stuardo Ávila V, Lisboa Donoso C, Low Andrade K, Solís D, Gómez D, Cortés E, Núñez Hernandez C, Parra Hidalgo V, Lobos Vega C, Belmar Prieto J, Contreras Hernández P, Carrasco-Portiño M, Bustos Ibarra C, Barrientos Delgado J.   +14 more
europepmc   +1 more source

BMP antagonist CHRDL2 enhances the cancer stem‐cell phenotype and increases chemotherapy resistance in colorectal cancer

Molecular Oncology, EarlyView.
Overexpression of CHRDL2 in colon cancer cells makes them more stem‐like and resistant to chemo‐ and radiotherapy. CHRDL2‐high cells have upregulation of the WNT pathway, genes involved in the DNA damage response (DDR) pathway and epithelial‐to‐mesenchymal transition (EMT). This leads to quicker repair of damaged DNA and more cell migration.
Eloise Clarkson, Annabelle Lewis
wiley   +1 more source

Identification and prioritization of population health indices in Iranian population, a qualitative study. [PDF]

BMC Public Health
Roohravan Benis M, Rampisheh Z, Motamed-Gorji N, Solhi M, Tayefi B.   +4 more
europepmc   +1 more source

Simultaneous inhibition of TRIM24 and TRIM28 sensitises prostate cancer cells to antiandrogen therapy, decreasing VEGF signalling and angiogenesis

Molecular Oncology, EarlyView.
TRIM24 and TRIM28 are androgen receptor (AR) coregulators which exhibit increased expression with cancer progression. Both TRIM24 and TRIM28 combine to influence the response of castrate‐resistant prostate cancer (CRPC) cells to AR inhibitors by mediating AR signalling, regulation of MYC and upregulating VEGF to promote angiogenesis. Castrate‐resistant
Damien A. Leach, Nilesh Chatterjee, Kellie Spahr, Gilberto Serrano de Almeida, Anabel Varela‐Carver, Taimur T. Shah, Mathias Winkler, Hashim U. Ahmed, Charlotte L. Bevan   +8 more
wiley   +1 more source