Results 271 to 280 of about 9,117,557 (397)

A Lung‐Immune Dual‐Humanized Mouse Using Cryopreserved Tissue Enables Infection and Immune Profiling of Human Common Cold Coronaviruses

Advanced Science, EarlyView.
Cryopreserved lung‐humanized mice overcome the dependency to fresh tissues and permit head‐to‐head profiling of all four human common cold coronaviruses versus SARS‐CoV‐2 infection; the model validates Paxlovid efficacy against HKU1 and, when coupled with human immune‐system engraftment, enables interrogation of lung‐resident human immunity and HKU1 ...
Chunyu Cheng, Jing Sun, Chun Lu, Qian Yu, Yiyun He, Bingqing Wu, Deshan Ren, Shuai Ding, Jincun Zhao, Yan Li   +9 more
wiley   +1 more source

Continuing education as a strategy of public health surveillance for sustainable development. [PDF]

Rev Bras Enferm
Nascimento TLD, Chagas HMA, Rodrigues MFS, Vasconcelos SP.   +3 more
europepmc   +1 more source

Microglial HVCN1 Deficiency Improves Movement and Survival of SOD1G93A ALS Mice by Enhancing Microglial Migration and Neuroprotection

Advanced Science, EarlyView.
Hydrogen voltage gated channel 1 (HVCN1) is upregulated in microglia of both ALS patients and its mouse model. HVCN1 deficiency enhances microglial migration via suppressing Akt signaling, promotes neurotrophic capacity and motor function, and prolongs survival of the SOD1G93A ALS mice. This study identifies HVCN1 as a novel, promising druggable target
Fan Wang, Ke‐Yu Zhang, Lang‐Jian Zhu, Wei‐Jue Li, Yang Wu, Xiang Gao, Xiao‐Ru Ma, Xiu‐Hua Yin, Jian‐Bin Wu, Xiao‐Kang Ye, Zhao‐Jun Dong, Di‐Xian Wang, Zhe Zhou, Shao‐Dong Wang, Lei Han, Zhi‐Nong Jiang, Jing‐Wei Zhao   +16 more
wiley   +1 more source

Barriers and opportunities in developing community-based maternal and child health surveillance: A mixed methods study in Depok, Indonesia. [PDF]

PLoS One
Sigit FS, Yelda F, Ayuningtyas D, Adisasmita AC, Prasetyo S.   +4 more
europepmc   +1 more source

Metrics for Public Health Perspective Surveillance of Bacterial Antibiotic Resistance in Low- and Middle-Income Countries

, 2020
Olga Tosas Auguet, René Niehus, Hyun S. Gweon, James A. Berkley, Joseph Waichungo, Tsi Njim, Jonathan D. Edgeworth, Rahul Batra, Kevin Chau, Jeremy Swann, Sarah Walker, Tim Peto, Derrick W. Crook, Sarah Lamble, Paul Turner, Ben S. Cooper, Nicole Stoesser   +16 more
openalex   +1 more source

Engineering Osteoimmune Responses with Functionalized Orthopedic Implants for Post‐Operative Osteosarcoma Treatment

Advanced Science, EarlyView.
Osteosarcoma is the most common primary bone tumor with limited treatment options and a terrible prognosis. This review provides a comprehensive summary of the recent development of osteoimmunomodulatory implants for post‐operative osteosarcoma treatment, of which the potential utility in evoking durable anti‐osteosarcoma immunity and accelerating bone
Yilong Dong, Lingshuang Wang, Hui Zhang, Menghuan Li, Zhong Luo, Yan Hu, Chunyuan Cai   +6 more
wiley   +1 more source

A Paradigm Shift in Health Surveillance: Preparing for the Future of Longevity. [PDF]

Int J Public Health
Jayaraj VJ, Chong DW, Ismail MZHB, Abdul Rahim NA, Ramoo K.   +4 more
europepmc   +1 more source

Evaluation of the Hospital Epidemiological Surveillance Network in Acre for responses to potential public health emergencies of international interest, 2020 to 2022

Valéria Nascimento de Moraes Brasil
openalex   +1 more source

Activating the Osteoblastic USP26 Pathway Alleviates Multi‐Organ Fibrosis by Decreasing Insulin Resistance

Advanced Science, EarlyView.
The loss of Ubiquitin Specific Peptidase 26 (USP26) in osteoblasts results in decreased bone formation, as well as multi‐organ fibrosis associated with insulin resistance (IR). Mechanistically, the absence of USP26 reduces glycolysis and lactate accumulation, leading to decreased histone H3 lysine 18 lactylation (H3K18LA) in the promoter region of KH ...
Jiyuan Tang, Wenkai Ye, Liang He, Zhou Dan, Leilei Chang, Zijie You, Yuanyue Jiang, Guoqing Tang, Lianfu Deng, Changwei Li   +9 more
wiley   +1 more source

A metagenomic approach to One Health surveillance of antimicrobial resistance in a UK veterinary centre. [PDF]

Microb Genom
Elton L, Mateos AD, Frosini SM, Jepson R, Rofael S, McHugh TD, Wey EQ.   +6 more
europepmc   +1 more source