Results 281 to 290 of about 9,117,557 (397)

Setting-based surveillance and One Health in the Mpox response [PDF]

Marc K Yambayamba, Simon R. Rüegg
openalex   +1 more source

METTL5 Enables Immune Evasion of Liver Cancer via Chemokine mRNA Translation Regulation

Advanced Science, EarlyView.
METTL5 reshapes the tumor immune microenvironment through ribosome 18S rRNA m6A modification to regulate the translation of chemokine mRNA. Targeting METTL5‐mediated immunosuppression unleashes anti‐tumor immunity and improves the efficacy of anti‐PD‐1 therapy.
Shuang Li, Xiao Zhao, Tongtong Song, Qiaoyi Chen, Yanqing Wu, Yuting Zhang, Jingying Chen, Yifan Wu, Bin Li, Xinyue Zhang, Zihao Dai, Lixia Xu, Yubin Xie, Alfred Sze‐Lok Cheng, Jianping Guo, Ming Kuang, Shuibin Lin, Zhenwei Peng, Sui Peng, Xuezhen Zeng   +19 more
wiley   +1 more source

Host‐Directed Antiviral Activity of SB2960 Through Selective Induction and Remodeling of Stress Granules

Advanced Science, EarlyView.
Amid the ongoing threat of emerging viral pathogens, host‐directed antivirals offer a strategy to overcome viral mutation and drug resistance. SB2960, a small‐molecule inducer of stress granules (SGs), exhibits potent broad‐spectrum antiviral activity with minimal cytotoxicity.
Wan Gi Byun, Sumin Son, JinAh Lee, Minha Lee, Meehyun Ko, Songrui Zhao, Ju Hee Kim, Kannan Vaithegi, Ji Hoon Kwon, Jung Ho Lee, Sangeun Jeon, Dawon Yi, Peng Zou, Seungtaek Kim, Seung Bum Park   +14 more
wiley   +1 more source

Author Correction: Forecasting influenza hospital admissions within English sub-regions using hierarchical generalised additive models

Communications Medicine
Jonathon Mellor, Rachel Christie, Christopher E. Overton, Robert S. Paton, Rhianna Leslie, Maria Tang, Sarah Deeny, Thomas Ward   +7 more
doaj   +1 more source

Multimorbidity, Mortality, and the COVID-19 Syndemic in Madagascar: A Decade of Health Surveillance Across 180 Diseases (2015-2024)

Modeste Kameni Nematchoua, Diana Ratsiambakaina, Faratiana Jenny Rasoariseheno, Rija Onintsoa Andriamasinoro, Nivoarimelina Zoly Rakotomalala, Razafindramboho Samoelà Hérédia, Nirina Henintsoa Raveloharimino, Herisitraka Raotoson, Harimbola Fiononantsoa Razaia Rakotovazaha, Rakotoson Mariette, Raphaël Randrianarivo, Vohangy Marie Anita Randriamihaja, Hery Henintsoa Randrianirina, Pâquerette Voahirantsoa Razanamiarana, Joseph K. David, W Cedric, Gaël Lauricia Lalanirina, Lindsay Kouatie Njonger, Philippe Manjakasoa Randriantsoa, Luc Narda Randrianahasina, Rakotomalala Vololoniana Razafimanalina, Assoumacou Noro Flavia, Larissa Lalatina Randriamialy, Lethicia Lydia Yasmine, Zely Arivelo Randriamanantany   +24 more
openalex   +1 more source

Flipping the Switch: MeCP2‐Mediated Lactylation Rewires Microglial Metabolism and Inflammation via the HK2/mTOR Axis in Poststroke Neuroinflammation

Advanced Science, EarlyView.
Stroke‐induced lactate accumulation promotes p300‐mediated lactylation of methyl‐CpG binding protein 2 (MeCP2) at lysine 210, which reprograms microglial metabolism toward glycolysis and activates the hexokinase 2 (HK2)/mTOR axis. This cascade promotes proinflammatory responses and impairs neurofunctional outcomes.
Zengyu Zhang, Shanshan Huang, Yong Wang, Zhiwen Jiang, Zhuohang Liu, Chenran Wang, Rong Ji, Yiwen Yuan, Xueyu Mao, Kaicheng Yang, Huicong Niu, Yanqin Gao, Jing Zhao   +12 more
wiley   +1 more source

A community-of-practice-built database to support the implementation and operation of national and subnational wildlife health surveillance systems. [PDF]

One Health
Montecino-Latorre D, Pruvot M, Shimabukuro PHF, Barker CM, Gallo S, Palmer J, Kutz SJ, Cayol C, Dórea F, Noguera LP, Joly DO, Walzer C, Keatts L, Fine AE, Olson SH.   +14 more
europepmc   +1 more source

ITGB1 Regulates Triple‐Negative Breast Cancer Development by Modulating the Tumor Microenvironment

Advanced Science, EarlyView.
ABSTRACT Tumorigenesis and metastasis are frequently attributed to the intricate interplay between cancer cells and the tumor microenvironment (TME). Comprehending the mechanisms and key regulators of cancer‐immune crosstalk in the TME is imperative for developing efficacious immunotherapy.
Nuozi Song, Siqi Chen, Lei Wang, Jessica Dang, Xu Cao, Stephanie Singh, Lu Yang, Jinhui Wang, Steven T. Rosen, Yingyu Wang, Chun‐Wei D. Chen, Cheng Zhang, Mingye Feng   +12 more
wiley   +1 more source

Health surveillance at mass gatherings: experience report from the Strategic Health Surveillance Information Center in the city of Rio de Janeiro, 2024. [PDF]

Epidemiol Serv Saude
Pimenta IT, Marsico EFC, Souto APM, Geraldo MCHM, Amaral LF, Duffrayer KM, Ribeiro CLP, Aguilar GMO.   +7 more
europepmc   +1 more source

Updated systematic review of respiratory health surveillance: what is the evidence and what are the knowledge gaps? [PDF]

Damien McElvenny, Ruth Wiggans, Jennie Hoyle, David Fishwick, Martie van Tongeren   +4 more
openalex   +1 more source