Results 301 to 310 of about 9,117,557 (397)

Shopping Data for Population Health Surveillance: Opportunities, Challenges, and Future Directions.

J Med Internet Res
Suhag A, Burgess R, Skatova A.
europepmc   +1 more source

Spillover of SARS-CoV-2 to domestic dogs in COVID-19-positive households: A one health surveillance study. [PDF]

Virus Res
Ramasamy S, Bustamante F, LaBella LC, Cole SD, Armstrong J, Thompson DL, Hardham JM, Kuchipudi SV, Tewari D.   +8 more
europepmc   +1 more source

GlycoChat Uncovers Glycan–Lectin Circuits in the Tumor Microenvironment of Pancreatic Cancer

Advanced Science, EarlyView.
Aberrant glycosylation drives cancer progression, yet its role in the tumor microenvironment remains unclear. We developed GlycoChat to map glycan–lectin circuits at single‐cell resolution. We discovered that cancer cells induce immunosuppressive macrophage differentiation and impair phagocytosis through interactions with CLEC10A and SIGLEC3 ...
Dinh Xuan Tuan Anh, Sunanda Keisham, Arun Burramsetty, Lalhaba Oinam, Koichiro Kumano, Akihiro Kuno, Osamu Shimomura, Tatsuya Oda, Hiroaki Tateno   +8 more
wiley   +1 more source

Challenges and recommendations for embracing digital tools for one health surveillance in LMICs: Viewpoints from a special session of 17th ISVEE. [PDF]

One Health
Nguyen-Tien T, Unger F, Yano T, Mutua F, Cook EAJ, Lee HS, Bett B, Nguyen-Viet H.   +7 more
europepmc   +1 more source

Amodiaquine Enhances Anti‐Melanoma Efficacy of Attenuated Salmonella via Targeting Glutathione Reductase in Neutrophils

Advanced Science, EarlyView.
This study shows that Salmonella VNP20009 recruits pro‐tumor neutrophils that reduce its anticancer efficacy. Combining VNP with amodiaquine selectively eliminates these neutrophils by targeting glutathione reductase. A GR‐shRNA‐loaded VNP strain was further developed, demonstrating an innovative strategy integrating drug repurposing with synthetic ...
Wanfa Dong, Chunyuan Zhao, Chengxi Li, Lin Weng, Zehan Ji, Peiqi Li, Jiqiang Lu, Danni Liu, Anni Yu, Tianyi Jiang, Shaokai Huang, Heng Liu, Xiao Chen, Zichun Hua   +13 more
wiley   +1 more source

Oropouche Virus Importation in Southern Brazil and Emerging Concern Calling for Enhanced Public Health Surveillance. [PDF]

J Med Virol
Dos Santos FM, de Melo ES, de Lima GB, da Silva AF, Paiva MHS, Acioli-Santos B, de Moraes CNL, Ruivo AP, Gregianini TS, Bauermann M, Bermann T, Lagranha VL, Baethgen LF, Godinho F, Wallau GDL, Veiga ABGD, Salvato RS.   +16 more
europepmc   +1 more source

Targeting Microglial CD49a Inhibits Neuroinflammation and Demonstrates Therapeutic Potential for Parkinson's Disease

Advanced Science, EarlyView.
This study shows that integrin receptor CD49a (Itga1 gene) is significantly upregulated in hyperactivated microglia and microglia‐specific knockdown of Itga1 rescues neuroinflammation and neurodegeneration in a chronic Parkinson's disease (PD) model by targeting PGAM5‐mediated mitochondrial dysfunction and NLRP3 activation. Targeted inhibition of CD49a
Huanpeng Lu, Yunmin Zhu, Xi Wang, Zelin Wu, Zijian Xu, Rongqing Chen, Yanwu Guo   +6 more
wiley   +1 more source

Veterinary Clinics as Reservoirs for <i>Pseudomonas aeruginosa</i>: A Neglected Pathway in One Health Surveillance. [PDF]

Antibiotics (Basel)
Nadăş GC, Manchon AM, Bouari CM, Fiț NI.   +3 more
europepmc   +1 more source

Advanced Human Immune Cell‐Organoid Co‐Cultures for Functional Testing of Cancer Nanovaccines

Advanced Science, EarlyView.
Pancreatic ductal adenocarcinoma remains difficult to treat. We establish an organoid–immune co‐culture using patient‐derived organoids and matched T‐cells to assess cancer vaccines. A mesothelin‐targeted nanovaccine activates antigen‐specific T‐cells, increases IFN‐γ, and targets MSLN+ organoids.
Nathalia Ferreira, David Agorku, Andre Rosa, Julia Roosz, Lena Christ, Nicole Anderle, Ajinkya Kulkarni, Abir Hussein, Sana S. Sayedipour, Omar F. Luna, Tobias Legler, Philipp Ströbel, Fernando Albericio, Luis Cruz, Phillipp Beckhove, Peter Loskill, Frauke Alves, M. Andrea Markus, Fernanda Ramos‐Gomes   +18 more
wiley   +1 more source

Leveraging wastewater sequencing to strengthen global public health surveillance. [PDF]

BMC Glob Public Health
Gordeev V, Hölzer M, Desirò D, Goraichuk IV, Knyazev S, Solo-Gabriele H, Skums P, Karthikeyan S, Evans A, Agrawal S, Lucaci AG, Mason CE, Su JM, Gibas C, Nagarajan N, Peres da Silva R, Drabcinski N, Munteanu V, Zhan L, Rubin J, Wu NC, Trister A, Ciorba D, Bostan V, Lobiuc A, Covasa M, Ophoff RA, Zelikovsky A, Dimian M, Mangul S.   +29 more
europepmc   +1 more source