Results 331 to 340 of about 12,741,957 (410)

Cytoplasmic p21 promotes stemness of colon cancer cells via activation of the NFκB pathway

open access: yesMolecular Oncology, EarlyView.
Cytoplasmic p21 promotes colorectal cancer stem cell (CSC) features by destabilizing the NFκB–IκB complex, activating NFκB signaling, and upregulating BCL‐xL and COX2. In contrast to nuclear p21, cytoplasmic p21 enhances spheroid formation and stemness transcription factor CD133.
Arnatchai Maiuthed   +10 more
wiley   +1 more source

Regional differences in prevalence, awareness, treatment and control of hypertension in Poland - comparison of two national multi-center health surveys: WOBASZ and WOBASZ II. [PDF]

open access: yesPLoS One
Wierzowiecka M   +11 more
europepmc   +1 more source

Class IIa HDACs forced degradation allows resensitization of oxaliplatin‐resistant FBXW7‐mutated colorectal cancer

open access: yesMolecular Oncology, EarlyView.
HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto   +13 more
wiley   +1 more source

Global, regional and national estimates of coexisting forms of malnutrition among the neonates, infants and young children - A secondary data analysis of Demographic & Health Surveys (DHS) from 2006 to 2024. [PDF]

open access: yesF1000Res
Khaliq A   +13 more
europepmc   +1 more source

Mental health among sexually and gender diverse adolescents in Indonesia and Vietnam: Results from the National Adolescent Mental Health Surveys. [PDF]

open access: yesChild Adolesc Psychiatry Ment Health
Fine SL   +11 more
europepmc   +1 more source

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