Results 121 to 130 of about 32,527,248 (315)

Design and analysis strategies for robust microbiome ageing research

FEBS Letters, EarlyView.
The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik, İsmail Güderer, Yi Wang, Tayyaba Alvi, Prasoon Pandey, Handan Melike Dönertaş   +5 more
wiley   +1 more source

Belgium: health system review

, 2007
171 p.The Health Systems in Transition (HiT) profiles are country-based reports that provide a detailed description of a health system and of policyinitiatives in progress or under development.
Merkur, Sherry, Palm, Willy, Jemiai, Nadia, Corens, Dirk, European Observatory on Health Systems and Policies, World Health Organization. Regional Office for Europe   +5 more
core  

Optimal anticoagulation strategy for atrial fibrillation ablation: are all direct oral anticoagulants and vitamin K antagonists the same? - a meta-analysis of embolic and bleeding complications in more than 31,500 patients

Romanian Journal of Cardiology
The direct oral anticoagulants (DOACS) such as dabigatran (D), rivaroxaban (R), apixaban (A), and edoxaban (E) have become the leading anticoagulation strategy in atrial fibrillation (AF).
Musat Dan L, Enache Bogdan, Musat Alexandra, Bhatt Advay, Habibi Mohammadali, Kochav Stephanie, Sichrovsky Tina, Preminger Mark W, Mittal Suneet   +8 more
doaj   +1 more source

ABL kinase‐dependent phosphorylation of SH proteins promotes their direct interaction with CRK family SH2 domains

FEBS Letters, EarlyView.
CT10 regulator of kinase (CRK) and CRK‐Like (CRKL) are signaling adaptors driving cell adhesion, motility, differentiation, and proliferation. SH2‐domain containing (SH) proteins are enriched in YXXP motifs which when phosphorylated create preferred binding sites for CRK family SH2 domains.
Phoebe M. Cousens, Brendan W. Chandler, Anna M. Schmoker, Jaye L. Weinert, Charlotte A. Kearns, Warren T. Yacawych, Amila Šemić, Alicia M. Ebert, Bryan A. Ballif   +8 more
wiley   +1 more source

Georgia: health system review

, 2017
xx, 90 p.This analysis of the Georgian health system reviews developments in its organization and governance, health financing, health care provision, health reforms and health system performance.
Richardson, Erica, European Observatory on Health Systems and Policies, World Health Organization. Regional Office for Europe, Berdzuli, Nino   +3 more
core  

Reconstructing enzyme evolution by protein engineering

FEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler, Markus R. Busch, Reinhard Sterner   +2 more
wiley   +1 more source

Azerbaijan: health system review

, 2010
115 p.The Health Systems in Transition (HiT) profiles are country-based reportsthat provide a detailed description of a health system and of policyinitiatives in progress or under development.
Ibrahimova, Aybaniz, Ibrahimov, Fuad, Richardson, Erica, European Observatory on Health Systems and Policies, Kehler, Jenni, World Health Organization. Regional Office for Europe   +5 more
core  

Identification of a Shiga toxin A‐derived peptide internalized into Gb3 receptor‐bearing cells via interaction with the Shiga toxin B subunit

FEBS Letters, EarlyView.
The process of internalization of the Shiga toxin A subunit via formation of a complex with the Shiga toxin B subunit, which specifically binds to the Gb3 receptor. The peptide is designed to act as a carrier of drugs into cancer cells. Here, we explored the potential of peptides derived from the catalytic A subunit of Shiga toxin (STxA) to be drug ...
Giulia Opassi, João C. Encarnação, Valeria Napolitano, Grzegorz Dubin, Grzegorz Popowicz, Karl Andersson, U. Helena Danielson   +6 more
wiley   +1 more source

Investigating transcription factor dynamics in health and disease using FRAP

FEBS Letters, EarlyView.
FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj, Carolina Vazquez Garzon, Jose Joaquin Velasco, Janine N. Post   +3 more
wiley   +1 more source

Ukraine: health system review

, 2015
154 p.This analysis of the Ukrainian health system reviews recent developmentsin organization and governance, health financing, health care provision,health reforms and health system performance. Since the country gainedindependence from the Soviet Union
Lekhan, Valery, Rudiy, Volodymyr, Shevchenko, Maryna, Nitzan Kaluski, Dorit, Richardson, Erica, European Observatory on Health Systems and Policies, World Health Organization. Regional Office for Europe   +6 more
core