Results 251 to 260 of about 32,527,248 (315)

PAK1 activation drives divergent resistance mechanisms to aromatase inhibition and tamoxifen in a luminal: A breast cancer model

Molecular Oncology, EarlyView.
Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller, Janina Müller, Efstathios‐Iason Vlachavas, Lukas Beumers, Lena Fleischhacker, Sara Burmester, Angelika Wörner, Sabine Karolus, Dominic Helm, Cindy Körner, Stefan Wiemann   +10 more
wiley   +1 more source

Ripple effects of a patient & health-system partnered engagement project: a co-developed protocol. [PDF]

Res Involv Engagem
Chana I, Ladak Z, Medvedyuk S, Saka A, Amenu B, Freedman H, Jeji T, Ramasamy V, Camus JC, Lofters A, Edwards A, Finley C, Riche D, Bloch GC, Manthorne J, Parsons J, Hochman J, Rogers J, Moffat J, Nyhof-Young J, Selby P, Dworkin S, Espin S, Redditt V, Wright V, Sayani A.   +25 more
europepmc   +1 more source

Spatial and single‐nuclei transcriptomics reveals idiosyncratic and generic patterns in papillary and anaplastic thyroid cancers

Molecular Oncology, EarlyView.
Matched spatial transcriptomics and single‐nuclei RNA‐seq were generated for anaplastic and BRAFV600E papillary thyroid cancers revealing generic and tumor‐specific states occurring in cancer cells and in the tumor microenvironment. In this context, cancer dedifferentiation mirrored organoid maturation through ordered thyroid marker gain/loss ...
Adrien Tourneur, Joel Rodrigues Vitória, Manuel Saiselet, Ligia Craciun, Denis Larsimont, Anne Lefort, Frédérick Libert, Carine Maenhaut, Sabine Costagliola, Maxime Tarabichi, Mirian Romitti, Vincent Detours   +11 more
wiley   +1 more source

Beyond prevalence: A complete catchment eye health system profile using rapid assessment of avoidable blindness, a population-based eye health survey, and the first implementation of the newly developed health system module. [PDF]

PLoS One
Sabherwal S, McCormick I, Javed M, Ramke J, B R S, Buttan S, Majumdar A, Silwal P, Chandi S, Lakhani B, Tyagi S, Deep U, Jain V, Bastawrous A.   +13 more
europepmc   +1 more source

Beyond immunity gaps: health-system constraints and measles mortality in Bangladesh. [PDF]

Trop Med Health
Hossain MS.
europepmc   +1 more source

Macroeconomic shock-response functions of health system resilience and equity: a global simulation study. [PDF]

Npj Health Syst
Momahhed SS, Haghighathoseini A.
europepmc   +1 more source

Status of COPD in Saudi Arabia: challenges, gaps, and opportunities for health system transformation. [PDF]

Front Public Health
Alqahtani JS.
europepmc   +1 more source

Interdisciplinary Occupational Health System for Recovery From Musculoskeletal Injuries in US Army Personnel.

JAMA Netw Open
Murray TA, Thompson AG, Wolff A, Richardson MD, Dummar AR, Bigelman KA.   +5 more
europepmc   +1 more source