Results 241 to 250 of about 3,126,798 (307)

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

Molecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric, Line Bjørge, Martine Rott Lode, Cecilie Fredvik Torkildsen, Pia Aehnlich, Rammah Elnour, Daniela Elena Costea, Lars Andreas Akslen, Liv Cecilie Vestrheim Thomsen, Emmet McCormack, Katrin Kleinmanns   +10 more
wiley   +1 more source

Learning Health Systems, Equity, and Bounded Justice: A Critical Scoping Review. [PDF]

Learn Health Syst
Thambinathan V, Lynch K, Moya M, Flores MG, Musalia RM, Rubin J, Lepczyk J, Williamson FA.   +7 more
europepmc   +1 more source

Differential expression of cancer‐related genes supports prediction of poor response to first‐line treatments in T‐ALL pediatric patients with high minimal residual disease

Molecular Oncology, EarlyView.
In the present work, we have identified a transcriptional signature based on the differential expression of six genes (BCL2&MAST4, HSH2D&LAT2, METRN&PITPNM2) that would facilitate the early detection of T‐cell acute lymphoblastic leukemia (T‐ALL) patients prone to a poor treatment response and could be implemented at diagnosis, along with other risk ...
Antonio Lahera, Laura Vela‐Martín, Pablo Fernández‐Navarro, José Luis López‐Lorenzo, Javier Cornago, Pilar Llamas, Eduardo Pérez‐Gómez, José Luis Marín‐Rubio, Manuel Fresno, Javier Santos, José Fernández‐Piqueras, María Villa‐Morales   +11 more
wiley   +1 more source

Transforming health systems in Tanzania towards universal health coverage: a scoping review of policy evolution, 1961-2025. [PDF]

BMJ Open
Kiremeji M, Kibusi SM, Eliakimu E, Mpagama SG, Julius M, Ngowi R, Armour A, Masuma J, Msemwa F, Nzeyimana E, Medarakani H, Kilindimo S, Katalambula L, Sawe H, Magembe G.   +14 more
europepmc   +1 more source

Editorial: Challenges, opportunities & outcomes of patient-oriented research in learning health systems. [PDF]

Front Health Serv
Manhas KP, Benzies K, Santana M, Wasylak T.   +3 more
europepmc   +1 more source

Trust is a verb: how to reimagine confidence in health systems. [PDF]

Health Promot Int
Purnat TD, Wilhelm E, Lihemo G, Scales D.   +3 more
europepmc   +1 more source

Knowledge Architecture for Race and Ethnic Group Defining in Learning Health Systems. [PDF]

Learn Health Syst
Hudson MF, van Staden VMS, Oostdyk AM, Martin JC.   +3 more
europepmc   +1 more source

Systematic review of cardiovascular care delivery across health systems in the Asia-Pacific: a regional roadmap for strengthening cardiovascular care. [PDF]

Lancet Reg Health West Pac
Chew NW, Kong G, Cader FA, Chen Y, Chong B, Chow CK, Goh R, Grey C, Guo Y, Himan HR, Matthias T, Nelson AJ, Rejack G, Rolleston A, Roy A, Sasikumar N, Sawano M, Beng Tan KC, Tern P, Tromp J, Yan LL, Yeo KK, Nicholls SJ, Lam CS, Lancet Commission on Tackling Cardiovascular Disease in the Asia Pacific Region.   +24 more
europepmc   +1 more source