Results 121 to 130 of about 5,578,781 (262)
Global Digital Transformation in Healthcare: Impact of Connected Healthcare Systems on Patient Safety [PDF]
Global Journal on Quality and Safety in HealthcareShaikh Muhammad Saif ud Din
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Molecular Oncology, EarlyView.Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat +8 more
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Digital health technology companies' experiences of the Finnish Digi-HTA method: An interview study
Finnish Journal of eHealth and eWelfareHealth Technology Assessment (HTA) is becoming a core activity for digital health technology companies. Engaging with HTA at the earliest possible stage is beneficial for companies in the development of solutions and in optimizing and prioritizing their
Petra Kämäräinen, Heidi Hintsala
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The PI3Kδ inhibitor roginolisib (IOA‐244) preserves T‐cell function and activity
Molecular Oncology, EarlyView.Identification of novel PI3K inhibitors with limited immune‐related adverse effects is highly sought after. We found that roginolisib and idelalisib inhibit chronic lymphocytic leukemia (CLL) cells and Treg suppressive functions to similar extents, but roginolisib affects cytotoxic T‐cell function and promotion of pro‐inflammatory T helper subsets to a
Elise Solli +7 more
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European Journal of Health Communication (EJHC)The use of digital health technologies could offer promising ways for sustainable health opportunities. However, the accessibility and use of such technologies differs between groups in society.
Joyce Bierbooms +3 more
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Basroparib inhibits YAP‐driven cancers by stabilizing angiomotin
Molecular Oncology, EarlyView.Basroparib, a selective tankyrase inhibitor, suppresses Wnt signaling and attenuates YAP‐driven oncogenic programs by stabilizing angiomotin. It promotes AMOT–YAP complex formation, enforces cytoplasmic YAP sequestration, inhibits YAP/TEAD transcription, and sensitizes YAP‐active cancers, including KRAS‐mutant colorectal cancer, to MEK inhibition.
Young‐Ju Kwon +4 more
wiley +1 more source
Jurnal Layanan Masyarakat (Journal of Public Services)Stunting is a form of malnutrition that serves as an important indicator for monitoring the growth and development of toddlers. However, assessing the nutritional status of toddlers does not stop at stunting, but includes a comprehensive understanding of
Nur Chamidah +5 more
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EVALUATING TELEMEDICINE IN RURAL SETTINGS: ISSUES AND APPLICATIONS [PDF]
Changes in health care policies, demographics, and technology have presented new opportunities for the delivery of medical care services and information to rural communities.
Capalbo, Susan M., Heggem, Christine N.
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Molecular Oncology, EarlyView.Meta‐transcriptome analysis identified FGF19 as a peptide enteroendocrine hormone associated with colorectal cancer prognosis. In vivo xenograft models showed release of FGF19 into the blood at levels that correlated with tumor volumes. Tumoral‐FGF19 altered murine liver metabolism through FGFR4, thereby reducing bile acid synthesis and increasing ...
Jordan M. Beardsley +5 more
wiley +1 more source
Molecular Oncology, EarlyView.This work identified serum proteins associated with pancreatic epithelial neoplasms (PanINs) and early‐stage PDAC. Proteomics screens assessed genetically engineered mice with abundant PanINs, KPC mice (Lox‐STOP‐Lox‐KrasG12D/+ Lox‐STOP‐Lox‐Trp53R172H/+ Pdx1‐Cre) before PDAC development and also early‐stage PDAC patients (n = 31), compared to benign ...
Hannah Mearns +10 more
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