Results 191 to 200 of about 934,440 (269)

Health technology assessment system in Switzerland: Current state, gaps, and prospects for improvement. [PDF]

PLOS Glob Public Health
Alkhaldi M, Kachach R, Enjalbert L, Al Basuoni A, Alrubaie M, Ahmed S.   +5 more
europepmc   +1 more source

Importin 7 mediates the nuclear import of HIV‐1 integrase via a specific interacting interface

FEBS Open Bio, EarlyView.
HIV‐1 integrase enables viral DNA integration into the host genome. By binding to the core domain of the host protein Importin 7 via its C‐terminal domain, the integrase is transported across the nuclear membrane into the nucleus, where integration of the viral genome into host DNA takes place. This translocation is a critical step for subsequent viral
Juana Bana, Avigail Yariv, Tal Oppenheim, Hadar Amartely, Dana Reichmann, Oded Livnah   +5 more
wiley   +1 more source

Malformin A1–mediated cytotoxicity in ovarian cancer cells occurs through pyroptosis and autophagy

FEBS Open Bio, EarlyView.
This study investigated the effects of the natural compound Malformin A1 (MA1) on the cytoskeleton that regulates cell proliferation and migration. Disruption of the cytoskeleton can impair these processes and promote cancer cell death. MA1 disrupted cytoskeletal organization, induced DNA damage, inflammation, activated autophagy, and pyroptosis ...
Nada Abdullah Hassan, Ikram A. Burney, Shika Hanif Malgundkar, Siva Ramamoorthy, Ressin Varghese, Mohamed A. Al‐Kindi, Hamad Al Riyami, Shadia Al Bahlani, Sergey Dobretsov, Syed Imran Hassan, Benjamin K. Tsang, Yahya Tamimi   +11 more
wiley   +1 more source

ATZ‐1 promotes DNA replication efficiency to maintain normal meiotic function

FEBS Open Bio, EarlyView.
Absence of ATZ‐1 interferes with meiotic DNA replication and cell cycle function via CHK‐1. This causes downstream defects associated with DNA damage and genomic integrity. Taken together, this study suggests that ATZ‐1 influences DNA replication efficiency and cell cycle function to maintain normal meiotic function.
Taylin E. Gourley, Luke W. Molesworth, Nethma H. Waduge, Fahimeh Eskandari, Peter R. Boag, Gregory M. Davis   +5 more
wiley   +1 more source

Strengthening health technology assessment (HTA) in the European Union: insights from Slovenia's implementation journey. [PDF]

Int J Technol Assess Health Care
Beravs-Bervar K, Goettsch W, Gutierrez-Ibarluzea I, Skali A, Rűther A, Lipska I, Turk E.   +6 more
europepmc   +1 more source

A comparative analysis of health technology assessment decision-making for cancer drugs in Germany and England. [PDF]

Front Public Health
He J, Wei H, Mo Q, Liu Y, Li X, Yang Y, Tian L.   +6 more
europepmc   +1 more source

Reframing early health technology assessment through a lifecycle lens: Commentary on "defining early health technology assessment: building consensus using Delphi technique". [PDF]

Int J Technol Assess Health Care
Gilardino R, Mittmann N, Mueller D, Pichler F.   +3 more
europepmc   +1 more source