Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment
Molecular Oncology, EarlyView.This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley +1 more source
Eastern Europe and the Former Soviet Union since the Fall of the Berlin Wall: Review of the Changes in the Environment and Natural Resources [PDF]
This paper reviews the environmental record of the transition countries of Eastern Europe and Central Asia since the fall of the Berlin Wall, with a focus on areas of key concern to public policy at the present time.
Anil Markandya, Wan-Jung Chou
core +3 more sources
Supporting children’s mental health and wellbeing at transition from primary to secondary school : Evidence review [PDF]
, 2020 White, Jane
core
Molecular Oncology, EarlyView.Meta‐transcriptome analysis identified FGF19 as a peptide enteroendocrine hormone associated with colorectal cancer prognosis. In vivo xenograft models showed release of FGF19 into the blood at levels that correlated with tumor volumes. Tumoral‐FGF19 altered murine liver metabolism through FGFR4, thereby reducing bile acid synthesis and increasing ...
Jordan M. Beardsley +5 more
wiley +1 more source
Digitally engaged physicians about the digital health transition. [PDF]
PLoS One, 2020 Győrffy Z, Radó N, Mesko B.
europepmc +1 more source
Choices, Challenges, and Options: Child SSI Recipients Preparing for the Transition to Adult Life [PDF]
, 2005 For young people receiving Supplemental Security Income (SSI), a means-tested cash benefit for children with disabilities, the transition into young adulthood is complicated for several reasons.
David Wittenburg, Pamela J. Loprest
core
Subtype‐specific enhancer RNAs define transcriptional regulators and prognosis in breast cancers
Molecular Oncology, EarlyView.This study employed machine learning methodologies to perform the subtype‐specific classification of RNA‐seq data sets, which are mapped on enhancers from TCGA‐derived breast cancer patients. Their integration with gene expression (referred to as ProxCReAM eRNAs) and chromatin accessibility profiles has the potential to identify lineage‐specific and ...
Aamena Y. Patel +6 more
wiley +1 more source
Molecular Oncology, EarlyView.Aldehyde dehydrogenase 1A1 (ALDH1A1) is a cancer stem cell marker in several malignancies. We established a novel epithelial cell line from rectal adenocarcinoma with unique overexpression of this enzyme. Genetic attenuation of ALDH1A1 led to increased invasive capacity and metastatic potential, the inhibition of proliferation activity, and ultimately ...
Martina Poturnajova +25 more
wiley +1 more source
New models of care in general practice for the youth mental health transition boundary. [PDF]
BJGP Open, 2020 Appleton R +5 more
europepmc +1 more source
Decomposition analysis of Spanish life expectancy at birth [PDF]
Using data from the Human Mortality Database (HMD), the paper analyzes the increase in the life expectancy of the Spanish population during the three decades, 1970-2001, in order to ascertain which age and sex groups have made the most progress in terms ...
Carl Boe, Rosa Gómez-Redondo
core