Results 181 to 190 of about 2,619,333 (310)

Health and the Urban Transition Effects of Household Perceptions, Illness, and Environmental Pollution on Clean Water Investment [PDF]

Recent efforts to reinvigorate the connections between urban planning and health have usefully brought the field back to one of its original roles.
Spencer, James H.
core  

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

Molecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric, Line Bjørge, Martine Rott Lode, Cecilie Fredvik Torkildsen, Pia Aehnlich, Rammah Elnour, Daniela Elena Costea, Lars Andreas Akslen, Liv Cecilie Vestrheim Thomsen, Emmet McCormack, Katrin Kleinmanns   +10 more
wiley   +1 more source

Learning from success: the main drivers of the maternal and newborn health transition in seven positive-outlier countries and implications for future policies and programmes. [PDF]

BMJ Glob Health
Campbell OMR, Amouzou A, Blumenberg C, Boerma T, Countdown to 2030 Exemplars Collaboration.   +4 more
europepmc   +1 more source

Hippo pathway at the crossroads of stemness and therapeutic resistance in breast cancer

Molecular Oncology, EarlyView.
Dysregulation of the Hippo pathway drives nuclear accumulation of YAP/TAZ, activating stemness‐related transcriptional programs that sustain breast cancer stemness and fuel therapeutic resistance across subtypes, underscoring Hippo signaling as a targetable vulnerability. Figure created and edited with BioRender.com.
Giulia Schiavoni, Antonella Palmese, Stefano Scalera, Laura Cipriani, Davide Mascolo, Patrizia Vici, Teresa Arcuri, Lorena Filomeno, Eriseld Krasniqi, Giovanni Blandino, Giulia Bon, Marcello Maugeri‐Saccà   +11 more
wiley   +1 more source

Systematic review of study designs and methods in health transition research for young people with intellectual disabilities. [PDF]

Heliyon, 2019
Kaehne A, Kiernan J, Ridley J.
europepmc   +1 more source

Deciphering transcriptional plasticity in pancreatic ductal adenocarcinoma reveals alterations in sensory neuron innervation

Molecular Oncology, EarlyView.
Pancreatic sensory neurons innervating healthy and PDAC tissue were retrogradely labeled and profiled by single‐cell RNA sequencing. Tumor‐associated innervation showed a dominant neurofilament‐positive subtype, altered mitochondrial gene signatures, and reduced non‐peptidergic neurons.
Elena Genova, Michele Montrone, Uday Rangaswamy, Francesco Diversi, Irene Schiavo, Denise Ferrarini, Roberta Di Florio, Irene Longo, Michele Coscia, Nicola Zamboni, Giorgia Demontis, Lisa Veghini, Vincenzo Corbo, Remo Sanges, Paul Heppenstall   +14 more
wiley   +1 more source

Does social capital determine health? Evidence from eight transition countries [PDF]

This paper starts from an empirical assessment of different dimensions of social capital in the transition countries of Central and Eastern Europe (CEE) and the Commonwealth of Independent States (CIS).
d'Hombres, Beatrice, McKee, Martin, Rocco, Lorenzo, Suhrcke, Marc   +3 more
core   +1 more source

CCDC80 suppresses high‐grade serous ovarian cancer migration via negative regulation of B7‐H3

Molecular Oncology, EarlyView.
PAX8 is a lineage‐specific master regulator of transcription in high‐grade serous ovarian cancer (HGSC) progression. We show for the first time that PAX8 facilitates proliferation and metastasis by repressing the cell autonomous tumor suppressor CCDC80 and inducing B7‐H3 expression.
Aya Saleh, Nitzan Medina‐Itzhaki, Milena Chekov, Eden Gal‐Swisa, Roba Gabesh‐Wahabi, Inbar Savyon, Inna Naroditsky, Hilary A. Kenny, Basem Fares, Lina Korsensky, Einav Girsh, Liron Berger, Ruth Perets   +12 more
wiley   +1 more source

Exploring Challenges and Opportunities in Hospital Disaster Preparedness: A Qualitative Study on the Perspectives of Hospital Incident Command System Members

Risk Management and Healthcare Policy
Prinka Singh,1,2 Sujan Sapkota,3 Nebil Achour,4 Luca Ragazzoni,1,2 Hamdi Lamine1,5 1CRIMEDIM-Center for Research and Training in Disaster Medicine, Humanitarian Aid and Global Health, Università Del Piemonte Orientale, Novara, 28100, Italy; 2Department ...
Singh P, Sapkota S, Achour N, Ragazzoni L, Lamine H   +4 more
doaj  

Sexual health, transition-related risk behavior and need for health care among transgender sex workers. [PDF]

Int J Transgend, 2019
Van Schuylenbergh J, Motmans J, Defreyne J, Somers A, T'Sjoen G.   +4 more
europepmc   +1 more source