Results 201 to 210 of about 10,030,185 (350)

Health Utility Values and Influencing Factors Among Pregnant and Postpartum Women in Rural Yunnan Province, China. [PDF]

Int J Womens Health
Wang X, Deng R, Yang Z, Liao R, Xiao Y, Yan C, Jiao F, Huang Y.   +7 more
europepmc   +1 more source

Patient‐specific pharmacogenomics demonstrates xCT as predictive therapeutic target in colon cancer with possible implications in tumor connectivity

Molecular Oncology, EarlyView.
This study integrates transcriptomic profiling of matched tumor and healthy tissues from 32 colorectal cancer patients with functional validation in patient‐derived organoids, revealing dysregulated metabolic programs driven by overexpressed xCT (SLC7A11) and SLC3A2, identifying an oncogenic cystine/glutamate transporter signature linked to ...
Marco Strecker, Keren Zohar, Martin Böttcher, Thomas Wartmann, Henry Freudenstein, Maximilian Doelling, Mihailo Andric, Wenjie Shi, Or Kakhlon, Katrin Hippe, Beatrix Jahnke, Dimitrios Mougiakakos, Franziska Baenke, Daniel Stange, Roland S. Croner, Michal Linial, Ulf D. Kahlert   +16 more
wiley   +1 more source

Health utility adjusted survival: A composite endpoint for clinical trial designs. [PDF]

Stat Methods Med Res
Deng Y, de Almeida J, Xu W.
europepmc   +1 more source

The virtual patient - Estimating the health utility of aspirin in simulated populations. [PDF]

Int J Cardiol Heart Vasc, 2021
Fender AC, Dobrev D.
europepmc   +1 more source

Feasibility of a ctDNA multigenic panel for non‐small‐cell lung cancer early detection and disease surveillance

Molecular Oncology, EarlyView.
Plasma‐based detection of actionable mutations is a promising approach in lung cancer management. Analysis of ctDNA with a multigene NGS panel identified TP53, KRAS, and EGFR as the most frequently altered, with TP53 and KRAS in treatment‐naïve patients and TP53 and EGFR in previously treated patients.
Giovanna Maria Stanfoca Casagrande, Marcela de Oliveira Silva, Mariana Bisarro dos Reis, Rodrigo de Oliveira Cavagna, Luciane Sussuchi, Icaro Alves Pinto, Natalia Zampieri Pontes, Rodrigo Sampaio Chiarantano, Flavio Augusto Ferreira da Silva, Pedro de Marchi, Letícia Ferro Leal, Rui M. Reis   +11 more
wiley   +1 more source

Development of the SF-6Dv2 health utility survey: comprehensibility and patient preference. [PDF]

J Patient Rep Outcomes, 2022
Broderick L, Bjorner JB, Lauher-Charest M, White MK, Kosinski M, Mulhern B, Brazier J.   +6 more
europepmc   +1 more source

Aggressive prostate cancer is associated with pericyte dysfunction

Molecular Oncology, EarlyView.
Tumor‐produced TGF‐β drives pericyte dysfunction in prostate cancer. This dysfunction is characterized by downregulation of some canonical pericyte markers (i.e., DES, CSPG4, and ACTA2) while maintaining the expression of others (i.e., PDGFRB, NOTCH3, and RGS5).
Anabel Martinez‐Romero, Ane Martinez‐Larrinaga, Joaquim Grego‐Bessa, Saioa Garcia‐Longarte, Hielke van Splunder, Ianire Astobiza, Amaia Ercilla, Laura Bozal‐Basterra, Isabel Mendizabal, Pilar Villacampa, Arkaitz Carracedo, Mariona Graupera   +11 more
wiley   +1 more source

Patient Validation of Estimation of Health Utility Values in Alopecia Areata. [PDF]

Pharmacoecon Open
Dixon C, Price T, Gruffydd E, Lloyd A, Law EH.   +4 more
europepmc   +1 more source

Impact of COVID-19 versus chronic rhinosinusitis/rhinitis associated olfactory dysfunction on health utility and quality of life. [PDF]

Laryngoscope Investig Otolaryngol, 2022
Luong T, Jang SS, Said M, DeConde AS, Yan CH.   +4 more
europepmc   +1 more source

Risk Attitudes in Health: An Exploratory Study [PDF]

Recent studies on human decision-making under uncertainty have revealed the following typical behavioral principles: (1) the importance of the status quo as a reference point ("target") for assessing outcomes, (2) the prevalence of risk-aversion for ...
Friedrich Breyer, Victor R. Fuchs
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