Results 31 to 40 of about 571,667 (259)

An isoform of 14‐3‐3 protein regulates transbilayer lipid movement at the plasma membrane

FEBS Letters, EarlyView.
Loss of 14‐3‐3ζ in CHO cells confers resistance to exogenous phosphatidylserine (PS) and impairs endocytosis‐independent inward flip‐flop of fluorescent PS at the plasma membrane. RNAi‐mediated knockdown reproduces this defect, while no additive effect is seen in ATP11C‐deficient cells.
Akiko Yamaji‐Hasegawa, Akira Hattori, Masafumi Tsujimoto, Toshihide Kobayashi   +3 more
wiley   +1 more source

Competency-based education model: a key tool for assessment and teaching in continuing medical education of infection prevention and control practitioners in different hospitals, China

BMC Medical Education
Background Competency-based frameworks have been widely adopted as the dominant approach to medical education. However, research investigating the impact of competency-based medical education (CBME) on infection prevention and control practitioners ...
Yao Yao, Zhuhong Zha, Guangying Luo, Bing Huang, Qin Zhang, Li Tian   +5 more
doaj   +1 more source

Review of research on competency of nosocomial infection control personnel in China

Shanghai yufang yixue
Nosocomial infection control personnel are crucial in ensuring the nosocomial infection management and the implementation of prevention and control measures.
SHI Qingfeng, HU Bijie, GAO Xiaodong, WANG Yanting, SUN Wei   +4 more
doaj   +1 more source

Understanding determinants of infection control practices in surgery: the role of shared ownership and team hierarchy

Antimicrobial Resistance and Infection Control, 2019
Background Despite a large literature on surgical site infection (SSI), the determinants of prevention behaviours in surgery remain poorly studied. Understanding key social and contextual components of surgical staff behaviour may help to design and ...
Rachael Troughton, Victor Mariano, Anne Campbell, Shehan Hettiaratchy, Alison Holmes, Gabriel Birgand   +5 more
doaj   +1 more source

Controlling healthcare-associated infections in the NHS [PDF]

Clinical Medicine, 2008
The prevention and control of healthcare-associated infection (HCAI) is a priority for the NHS. The delivery of national targets for reducing methicillin resistant Staphylococcus aureus bacteraemias and Clostridium difficile infection are supported by enhanced mandatory surveillance through the Health Protection Agency and a Department of Health ...
openaire   +2 more sources

Finding novel vulnerabilities of hypomorphic BRCA1 alleles

Molecular Oncology, EarlyView.
Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder, Klaas de Lint, Hồ Mỹ Phúc Võ, Mariana M. Góis, Rosalie A. Kampen, Marta San Martin Alonso, Ilse Nootenboom, Veronica Garzero, Tiemen J. Wendel, Rob M. F. Wolthuis, Sylvie M. Noordermeer   +10 more
wiley   +1 more source

Hospitalization costs due to healthcare-associated infections: An analysis of propensity score matching

Journal of Infection and Public Health, 2019
Background: In 2018, diagnosis-related group-based prospective payment system (DRG-PPS) was implemented nationwide by China that did not fully consider the additional costs caused by healthcare-associated infections (HAIs).
Yu Lv, Lan Chen, Wu Yu J., Qian Xiang, Qiong S. Tang, Feng D. Wang, Hong M. Cai, Kun Zou, Qiong D. Wei, Hua Z. Zhou, Hui Wang, Chen Wang, Jing Chen, Ting L. Li, Ying Fang, Huan Wang   +15 more
doaj   +1 more source

Partial FAK suppression promotes tumor growth, an effect reversed by macrophage p110δ PI3K inactivation

Molecular Oncology, EarlyView.
Partial inhibition of focal adhesion kinase (FAK) can paradoxically promote tumor growth, rather than simply producing a weaker antitumor effect than that observed with strong FAK suppression. In breast cancer and melanoma models, targeting p110δ PI3K, particularly in macrophages, counteracted these tumor‐promoting effects, highlighting the importance ...
Lydia Xenou, Niki Tzenaki, Anna Tsapara, Maria Tzardi, Evangelia A. Papakonstanti   +4 more
wiley   +1 more source

Cost–benefit analysis of surveillance for surgical site infection following caesarean section

BMJ Open, 2020
Objective To estimate the economic burden to the health service of surgical site infection following caesarean section and to identify potential savings achievable through implementation of a surveillance programme.Design Economic model to evaluate the ...
Catherine Wloch, Albert Jan Van Hoek, Nathan Green, Joanna Conneely, Pauline Harrington, Elizabeth Sheridan, Jennie Wilson, Theresa Lamagni   +7 more
doaj   +1 more source

Mutant p53R273H disrupts PDPK1 homodimerization and contributes to PDPK1 activation

Molecular Oncology, EarlyView.
How mutant p53R273H drives AKT signaling is unclear. We show that p53R273H, but not wild‐type, directly binds PDPK1 via a mutation‐dependent conformational change. This interaction disrupts inhibitory PDPK1 homodimerization and enhances AKT phosphorylation.
Mei Chee Lim, Alvin Kunyao Guo, Yoko Itahana, Srinivasaraghavan Kannan, Valerie Goh, Mingmin Ong, Terina Yan Wen Tay, Weiying Ye, Sabhashina Radha Krishnan, Jun Nishiyama, Chandra S Verma, Koji Itahana   +11 more
wiley   +1 more source