Results 211 to 220 of about 10,077,064 (287)

Integrated O2 and H2 Gas Therapy via Microneedle‐Assisted Photocatalytic Water Splitting for Accelerating Diabetic Full‐Thickness Skin Wound Healing

Advanced Science, EarlyView.
A concept of integrated O2 and H2 gas therapy is achieved using a gas‐producing material. PMP nanoparticles, fabricated from platinum, MIL‐101(Fe)‐NH2, and phosphotungstic acid, are integrated into bilayer gelatin methacryloyl microneedles for transdermal delivery. These microneedles enable integrated O2 and H2 gas therapy and promote wound healing via
Zesheng Chen, Yanchao Yu, Xingyuan Xiao, Wenwen Cheng, Ye Yang, Zhengyao Zhang, Wang Wang, Zhijun Zhou, Weikang Hu, Xiaolong Wang, Bing Li, Kwang Leong Choy, Yun Chen, Zijian Wang   +13 more
wiley   +1 more source

Health Care-Associated Infections in U.S. Hospitals, 2023 versus 2015. [PDF]

N Engl J Med
Chea N, Li R, Eure T, Alkis Ramirez R, Nadle J, Lee JE, Lehmann M, Sardenga L, Czaja CA, Johnston H, Kellogg M, Emanuel C, Cilwick A, Correa MA, Maloney M, Ray SM, Howard-Anderson J, Carswell S, Wilson LE, Perlmutter R, Marceaux-Galli K, Mahoehney JP, Lynfield R, Sievers M, Cline C, Judson M, Dumyati G, Hurley C, Keller E, Walsh M, Licherdell E, Tellerman J, Pierce R, Ocampo VLS, Samper ME, Hires KA, Adrian LT, Tammer RP, Zhang A, Hiratzka S, Dusko A, Wilson C, Harriott M, Smith H, Russo V, Boswell L, Godfrey D, Leaptrot D, McMeen M, Otis M, Watkins J, Taylor A, Allen R, Thompson ND, Edwards JR, Magill SS, Grigg CT.   +56 more
europepmc   +1 more source

CAR‐Engineered Cell Therapies Beyond Cancer: Reprogramming Fibrosis and Immune‐Mediated Inflammation

Advanced Science, EarlyView.
CAR‐engineered cell therapies are expanding beyond cancer toward immune resetting, pathological‐cell clearance, matrix remodeling, and microenvironmental reprogramming in autoimmune, inflammatory, and fibrotic diseases. This Review compares CAR‐T, CAR‐macrophage, and CAR‐NK platforms and proposes controllable spatiotemporal reprogramming to align ...
Peng Jun Xu, Zhou Jing Zhang, Jing Jin, Hai Yuan Xu, Ya Xin Gu, Qian Qian Yang, You Lang Zhou   +6 more
wiley   +1 more source

Evaluating a pathogen-specific IgG binding assay for rapid detection of healthcare-associated infections. [PDF]

Sci Rep
Karakullukçu A, Akker M, Kuşkucu MA, Aygün G, Dikmen Y.   +4 more
europepmc   +1 more source

A Metal‐Polyphenol Self‐Assembled Coated 3D Sponge With Mild Photothermal Antibacterial, Exudate‐Controlling, and Immunomodulatory Functions for Hemostasis and Chronic Wound Healing

Advanced Science, EarlyView.
A thrombin‐functionalized copper‐polydopamine nanofiber sponge integrates rapid hemostasis, mild photothermal antibacterial therapy, stimulus‐responsive Cu2+ release, chemodynamic oxidative stress, and macrophage immunomodulation. This multifunctional dressing suppresses infection, regulates inflammation, promotes angiogenesis and re‐epithelialization,
Ziwei Zhang, Feng Qin, Xiaomeng Zhang, Xueqin Shuang, Jiahua Zhou, Ming Cheng, Baicheng Lu, Mingyue Song, Yuntian Bai, Dianying Zhang, Ming Li, Yanhua Wang   +11 more
wiley   +1 more source

Cumulative Vulnerability in Cardiac Critical Care: A Framework for Understanding Healthcare-Associated Infections and Their Progression to Severe Infection and Sepsis. [PDF]

Medicina (Kaunas)
Vîrtosu DM, Dragomir A, Crișan S, Luca S, Pătru O, Băghină RM, Lazăr MA, Cozlac AR, Iurciuc S, Luca CT.   +9 more
europepmc   +1 more source

FTSJ3‐Mediated 2′‐O‐Methylation of HSPA5 mRNA Stabilizes BOP1 via SUMOylation to Drive DRP1‐Dependent Mitochondrial Fission and Fatty Acid Oxidation in Lung Squamous Cell Carcinoma

Advanced Science, EarlyView.
The RNA methyltransferase FTSJ3 drives lung squamous cell carcinoma progression by catalyzing 2′‐O‐methylation of HSPA5 mRNA, which stabilizes BOP1 through SUMOylation and activates DRP1/SREBP1‐mediated mitochondrial fission and fatty acid oxidation. Targeting this axis with liposomal siRNA potently suppresses tumor growth and metastasis ABSTRACT Lung ...
Qin Hu, Jiaheng Lin, Yifei Zhu, Ying Liu, Guoren Zhou   +4 more
wiley   +1 more source

Beyond the Reported Numbers: <i>Clostridioides difficile</i> Dominance (CDI) and Surveillance Bias in Healthcare-Associated Infections in Post-Pandemic Southeast Romania. [PDF]

Antibiotics (Basel)
Condratovici AP, Debita M, Stoian VI, Condratovici CP, Tupu AE, Tudor SS.   +5 more
europepmc   +1 more source

Upadacitinib Restrains the Pathogenic Fitness of CD4+ T Cells and Aberrant B Cell Programming in Optic Neuritis

Advanced Science, EarlyView.
Single‐cell profiling and functional perturbation reveal coordinated JAK1‐pSTAT3 downstream programs in optic neuritis, including MCL1‐dependent fitness of pathogenic CD4+ Tem cells and glycolysis‐linked, cholesterol‐sensitive B‐cell responses associated with RORA. Upadacitinib disrupts this reciprocal T‐B‐cell circuit and alleviates neuroinflammation,
Gengchen Jiang, Qi Jiang, Lian Han, Yue Peng, Xingyu Liu, Tong Yang, Hao Huang, Jiaying Liu, Yuan Gao, Hui Yang, Wenjun Zou, Zhaohuai Li, Wenru Su   +12 more
wiley   +1 more source