Results 31 to 40 of about 10,077,064 (287)

Establishing an Apheresis Medicine Program in a Resource‐Constrained Setting: A 5‐Year Experience From Lagos, Nigeria

Therapeutic Apheresis and Dialysis, EarlyView.
ABSTRACT Background Establishing a comprehensive apheresis medicine program in a resource‐constrained setting presents significant structural, financial, and logistical challenges. Despite the growing clinical importance of apheresis services globally, published experience from sub‐Saharan Africa remains sparse.
Folasade Adelekan‐Popoola, Shakirat Gold‐Olufadi, Olufunto Olufela Kalejaiye, Abdullateef Ogala, Rasheed A. Balogun   +4 more
wiley   +1 more source

Understanding the landscape of carbapenemase-producing organisms (CPOs), and spotlighting opportunities for control in England

Infection Prevention in Practice
SUMMARY: Carbapenemase-producing organisms (CPOs) are an increasing global public health threat for which there are limited effective and affordable therapeutic options. The rise in the incidence of CPO infections and colonisations recorded across the UK
Akaninyene Otu, Jacquelyn McCormick, Katherine L. Henderson, Alice Ledda, Danièle Meunier, Bharat Patel, Colin S. Brown, Susie Singleton, Emily L. Mason, Jasmin Islam, Ginny Moore, Katie L. Hopkins, Dakshika Jeyaratnam   +12 more
doaj   +1 more source

Profiling the Effects of Systemic Antibiotics for Acne, Including the Narrow-Spectrum Antibiotic Sarecycline, on the Human Gut Microbiota

Frontiers in Microbiology, 2022
Treatment for moderate-to-severe acne vulgaris relies on prolonged use of oral tetracycline-class antibiotics; however, these broad-spectrum antibiotics are often associated with off-target effects and negative gastrointestinal sequelae. Sarecycline is a
Ines B. Moura, Ayman Grada, William Spittal, Emma Clark, Duncan Ewin, James Altringham, Emilio Fumero, Mark H. Wilcox, Mark H. Wilcox, Anthony M. Buckley, Anthony M. Buckley   +10 more
doaj   +1 more source

Healthcare-Associated Infection and Hospital Readmission [PDF]

Infection Control & Hospital Epidemiology, 2012
Objective.Hospital readmissions are a current target of initiatives to reduce healthcare costs. This study quantified the association between having a clinical culture positive for 1 of 3 prevalent hospital-associated organisms and time to hospital readmission.Design.Retrospective cohort study.Patients and Setting.Adults admitted to an academic ...
Carley B, Emerson, Lindsay M, Eyzaguirre, Jennifer S, Albrecht, Angela C, Comer, Anthony D, Harris, Jon P, Furuno   +5 more
openaire   +2 more sources

An isoform of 14‐3‐3 protein regulates transbilayer lipid movement at the plasma membrane

FEBS Letters, EarlyView.
Loss of 14‐3‐3ζ in CHO cells confers resistance to exogenous phosphatidylserine (PS) and impairs endocytosis‐independent inward flip‐flop of fluorescent PS at the plasma membrane. RNAi‐mediated knockdown reproduces this defect, while no additive effect is seen in ATP11C‐deficient cells.
Akiko Yamaji‐Hasegawa, Akira Hattori, Masafumi Tsujimoto, Toshihide Kobayashi   +3 more
wiley   +1 more source

Structural insights and therapeutic targets in Acinetobacter baumannii capsule biosynthesis

FEBS Letters, EarlyView.
Hypervirulent KL49 A. baumannii's capsular polysaccharide contains the nonulosonic acid 8‐epi‐Leg5,7Ac2, synthesized by epimerization via ElaA, ElaB, and ElaC. Crystal structures of ElaA, ElaB, and ElaC reveal their role in CMP‐Leg5,7Ac2 synthesis and regioselective C8 epimerization.
Woo Cheol Lee, Junho Jeong, Chae Yeong Lee, Hyunjoon Cho, Man Hwan Oh, Je Chul Lee, Jee‐Young Lee, Yangmee Kim   +7 more
wiley   +1 more source

The relative importance of large problems far away versus small problems closer to home: insights into limiting the spread of antimicrobial resistance in England

BMC Medicine, 2017
Background To combat the spread of antimicrobial resistance (AMR), hospitals are advised to screen high-risk patients for carriage of antibiotic-resistant bacteria on admission.
Tjibbe Donker, Katherine L. Henderson, Katie L. Hopkins, Andrew R. Dodgson, Stephanie Thomas, Derrick W. Crook, Tim E. A. Peto, Alan P. Johnson, Neil Woodford, A. Sarah Walker, Julie V. Robotham   +10 more
doaj   +1 more source

The role of water in healthcare-associated infections [PDF]

Current Opinion in Infectious Diseases, 2013
The aim is to discuss the epidemiology of infections that arise from contaminated water in healthcare settings, including Legionnaires' disease, other Gram-negative pathogens, nontuberculous mycobacteria, and fungi.Legionella can colonize a hospital water system and infect patients despite use of preventive disinfectants.
Brooke K, Decker, Tara N, Palmore
openaire   +2 more sources

An epithelial GPR35 isoform supports tumor‐associated transcriptional and metabolic phenotypes

FEBS Letters, EarlyView.
GPR35 generates two functionally distinct isoforms with previously unresolved roles. GPR35‐short mediates immune‐cell chemotaxis, while GPR35‐long is enriched in colorectal cancer epithelium, where it supports increased metabolism, proliferation, and tumor‐associated transcriptional programs.
Jørgen D. Rønneberg, Martine Hjeltnes, Josephine Krieger, Joshua E. Elias, Maria Stensland, Kristian Holm, Xiaojun Jiang, Chuki Khangsar, Tuula A. Nyman, Arthur Kaser, Johannes R. Hov, Tom H. Karlsen, Nicole C. Kaneider, Frode L. Jahnsen, Georg Schneditz   +14 more
wiley   +1 more source

Finding novel vulnerabilities of hypomorphic BRCA1 alleles

Molecular Oncology, EarlyView.
Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder, Klaas de Lint, Hồ Mỹ Phúc Võ, Mariana M. Góis, Rosalie A. Kampen, Marta San Martin Alonso, Ilse Nootenboom, Veronica Garzero, Tiemen J. Wendel, Rob M. F. Wolthuis, Sylvie M. Noordermeer   +10 more
wiley   +1 more source