Results 71 to 80 of about 14,526,319 (291)

Gaps in communication theory paradigms when conducting implementation science research: qualitative observations from interviews with administrators, implementors, and evaluators of rural health programs

Implementation Science
Background Communication is considered an inherent element of nearly every implementation strategy. Often it is seen as a means for imparting new information between stakeholders, representing a Transaction orientation to communication.
Nicole L. Johnson, Jennifer Van Tiem, Erin Balkenende, DeShauna Jones, Julia E. Friberg, Emily E. Chasco, Jane Moeckli, Kenda S. Steffensmeier, Melissa J. A. Steffen, Kanika Arora, Borsika A. Rabin, Heather Schacht Reisinger   +11 more
doaj   +1 more source

Golgi enzymes are retrieved from the plasma membrane to the trans‐Golgi network

FEBS Letters, EarlyView.
Golgi enzymes are traditionally considered resident proteins retained within the Golgi apparatus. Here, we demonstrate that a subset transiently reaches the cell surface and is subsequently retrieved to the trans‐Golgi network via retrograde transport. Using a nanobody‐based toolkit, we uncover a dynamic trafficking cycle of several Golgi enzymes.
Dominik P. Buser, Tina Junne
wiley   +1 more source

Using Narrative Films to Combat HIV-Related Stigma in Western Kenya: An Exploratory Pilot Study of Adolescents Living With HIV and Their Caregivers

Global Pediatric Health
Objective. Interventions that effectively address HIV-related stigma are urgently needed to improve outcomes for adolescents living with HIV (ALHIV). We piloted a series of 4 short narrative films depicting Kenyan ALHIV’s lived experiences of stigma and ...
Brittany M. McCoy MD, Carole I. McAteer MS, Celestine Ashimosi, Josephine Aluoch MS, C. Thomas Lewis MFA, Winstone Nyandiko MBChB, MMED, MPH, Rachel C. Vreeman MD, MS   +6 more
doaj   +1 more source

Access Healthcare: A Model to Provide Improved Access to High-Quality and Affordable Healthcare [PDF]

North Carolina Medical Journal, 2005
he Access Healthcare model is based on a combination of new and vintage approaches to patient care that work together to provide reasonable solutions to some of the current problems in the healthcare system. The hypothesis of the Access Healthcare model is that if practices can decrease overhead and collect payments at the time of service (i.e ...
openaire   +2 more sources

Ligand‐dependent transcriptional heterogeneity in cell cycle gene expression delays G1/S entry

FEBS Letters, EarlyView.
EGF and HRG induce distinct G1/S progression programs in ErbB2‐amplified BT474 breast cancer cells. Despite activating the potent ErbB2–ErbB3 heterodimer, HRG does not accelerate cell‐cycle entry. Instead, EGF promotes earlier restriction‐point passage via ERK–FOS signaling, whereas HRG activates the AKT–MYC axis, driving transcriptional heterogeneity ...
Ririn Rahmala Febri, Ayaka Nagasato‐Ichikawa, Keita Iida, Shuhei Kimura, Akira Imamoto, Mariko Okada   +5 more
wiley   +1 more source

The ethics of research involving biobanking specimens from Kenyan children and adolescents living with HIV: discrepancies between individual perceptions and policy considerations

BMC Medical Ethics
Introduction Biobanking is common in research involving young people living with HIV (YPLHIV). The ethics and policies guiding this practice require careful consideration, especially given the population’s multiple vulnerabilities, like age, HIV status ...
Kevin Griffee, Winstone Nyandiko, Sakshi Sawarkar, Ashley Chory, Josephine Aluoch, Emma Gillette, Michael Scanlon, Hillary Koros, Daniel Lagat, Nandini Choudhury, Dennis Munyoro, Celestine Ashimosi, Whitney Biegon, Janet Lidweye, Jack Nyagaya, Allison DeLong, Violet Naanyu, Rachel Vreeman, Rami Kantor   +18 more
doaj   +1 more source

Structural and biochemical analysis of a B12 superbinder

FEBS Letters, EarlyView.
BtuG proteins are vitamin B12 scavengers in Bacteroides thetaiotaomicron, a dominant human gut bacterium. We present crystal structures of three BtuG homologs bound to cobalamin and its precursor cobinamide, revealing picomolar binding affinities, among the highest known for any natural protein.
Jose M. Martinez Felices, Jacob J. Whittaker, Dirk J. Slotboom, Albert Guskov   +3 more
wiley   +1 more source

Disease Burden and Treatment-Seeking Behaviour of Adults with Atopic Dermatitis in Singapore: An Online Cross-Sectional Survey

Dermatology and Therapy
Introduction Atopic dermatitis (AD) is a chronic systemic inflammatory skin disease with a notably high prevalence in Singapore. Despite available treatments, a significant proportion of patients remain untreated, highlighting a critical need to ...
Yik Weng Yew, Malvin Kang, Sharanya Jois, Adrien Gras, Christian Apfelbacher   +4 more
doaj   +1 more source

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source

Redefining Healthcare Infrastructure: Moving Toward Integrated Solutions [PDF]

, 2010
Currently in the United Kingdom there is a trend to broaden the scope of service provision in the healthcare sector. Not only are new healthcare-related services being provided to the community, but also there is increasing concern for providing ...
Formoso, Carlos Torres, Tillmann, Patricia, Tzortzopoulos, Patricia   +2 more
core   +3 more sources